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The genetics of neurosystems in mental ill-health and suicidality: Beyond serotonin

Published online by Cambridge University Press:  16 April 2020

D. Rujescu  and
I. Giegling
D. Rujescu*
Affiliation:
Department of Psychiatry, Ludwig-Maximilians University, Nußbaumstr. 7, 80336München, Germany
I. Giegling
Affiliation:
Department of Psychiatry, Ludwig-Maximilians University, Nußbaumstr. 7, 80336München, Germany
*
*Corresponding author. Tel.: +49 89 5160 5756; fax: +49 89 5160 5779. E-mail address: Dan.Rujescu@med.uni-muenchen.de (D. Rujescu).
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Abstract

Suicidal behavior is a major health problem worldwide. The risk of suicide-related behavior is supposed to be determined by a complex interplay of sociocultural factors, psychiatric history, personality traits, and genetic vulnerability. Family and twin studies point towards a partial heritability of suicidal behavior. First molecular genetic studies concentrated on genes of the serotonergic system based on the biochemical evidence that serotonergic neurotransmission is implicated in this behavior. Furthermore, genes of e.g. the dopaminergic and noradrenergic neurotransmitter systems have also been the subject of investigations in this context. The aim of this article is to review molecular genetic studies in suicidal behavior beyond the serotonergic system and to emphasize findings on new genes.

Keywords

SuicideAggressionGeneticsSerotoninImpulsivityPolymorphism
Type
Original article
Information
European Psychiatry , Volume 25 , Issue 5: The role of genetics in promoting suicide prevention and the mental health of the population - Nobel Conference: The role of genetics in promoting suicide prevention and the mental health of the population , June 2010 , pp. 272 - 274
Copyright
Copyright © Elsevier Masson SAS 2010

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References

Baca-Garcia, E, Vaquero, C, Diaz-Sastre, C, Jimenez-Treviño, L, Saiz-Ruiz, J, Fernández-Piqueras, Jet al.Lack of association between polymorphic variations in the alpha 3 subunit GABA receptor gene (GABRA3) and suicide attempts. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:409–412.CrossRefGoogle ScholarPubMed
Currier, D, Mann, JJStress, genes and the biology of suicidal behavior. Psychiatr Clin North Am 2008;31:247–269.CrossRefGoogle ScholarPubMed
De Luca, V, Strauss, J, Kennedy, JLPower based association analysis (PBAT) of serotonergic and noradrenergic polymorphisms in bipolar patients with suicidal behaviour. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:197–203.CrossRefGoogle ScholarPubMed
Dwivedi, Y, Rizavi, HS, Conley, RR, Roberts, RC, Tamminga, CA, Pandey, GNAltered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 2003;60:804–815.CrossRefGoogle ScholarPubMed
Finckh, U, Rommelspacher, H, Kuhn, S, Dufeu, P, Otto, G, Heinz, Aet al.Influence of the dopamine D2 receptor (DRD2) genotype on neuroadaptive effects of alcohol and the clinical outcome of alcoholism. Pharmacogenetics 1997;7:271–281.CrossRefGoogle ScholarPubMed
Giegling, I, Rujescu, D, Mandelli, L, Schneider, B, Hartmann, AM, Schnabel, Aet al.Estrogen receptor gene 1 variants are not associated with suicidal behavior. Psychiatry Res 2008;160:1–7.CrossRefGoogle Scholar
Giegling, I, Moreno-De-Luca, D, Rujescu, D, Schneider, B, Hartmann, AM, Schnabel, Aet al.Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior. Am J Med Genet B Neuropsychiatr Genet 2008;147:308–315.CrossRefGoogle ScholarPubMed
Ho, LW, Furlong, RA, Rubinsztein, JS, Walsh, C, Paykel, ES, Rubinsztein, DCGenetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder. Am J Med Genet 2000;96:36–42.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Hong, CJ, Huo, SJ, Yen, FC, Tung, CL, Pan, GM, Tsai, SJAssociation study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 2003;48:186–189.CrossRefGoogle ScholarPubMed
Iga, J, Ueno, S, Yamauchi, K, Numata, S, Tayoshi-Shibuya, S, Kinouchi, Set al.The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients. Am J Med Genet B Neuropsychiatr Genet. 144B 2007 1003–1006.CrossRefGoogle ScholarPubMed
Johann, M, Putzhammer, A, Eichhammer, P, Wodarz, NAssociation of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. Am J Med Genet B Neuropsychiatr Genet. 132B 2005 46–49.CrossRefGoogle ScholarPubMed
Kia-Keating, BM, Glatt, SJ, Tsuang, MTMeta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior. Am J Med Genet B Neuropsychiatr Genet. 144B 2007 1048–1053.CrossRefGoogle Scholar
Kim, B, Kim, CY, Hong, JP, Kim, SY, Lee, C, Joo, YHBrain-derived neurotrophic factor Val/Met polymorphism and bipolar disorder. Association of the Met allele with suicidal behavior of bipolar patients. Neuropsychobiology 2008;58:97–103.CrossRefGoogle ScholarPubMed
Merali, Z, Du, L, Hrdina, P, Palkovits, M, Faludi, G, Poulter, MOet al.Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region. J Neurosci 2004;24:1478–1485.CrossRefGoogle ScholarPubMed
Pandey, GN, Dwivedi, YNoradrenergic function in suicide. Arch Suicide Res 2007;11:235–246.CrossRefGoogle ScholarPubMed
Persson, ML, Geijer, T, Wasserman, D, Rockah, R, Frisch, A, Michaelovsky, Eet al.Lack of association between suicide attempt and a polymorphism at the dopamine receptor D4 locus. Psychiatr Genet 1999;9:97–100.CrossRefGoogle Scholar
Rujescu, D, Giegling, I, Gietl, A, Hartmann, AM, Möller, HJA functional single nucleotide polymorphism (V158 M) in the COMT gene is associated with aggressive personality traits. Biol Psychiatry 2003;54:34–39.CrossRefGoogle Scholar
Rujescu, D, Thalmeier, A, Möller, HJ, Bronisch, T, Giegling, IMolecular genetic findings in suicidal behavior: what is beyond the serotonergic system?. Arch Suicide Res 2007;11:17–40.CrossRefGoogle ScholarPubMed
Rujescu, D, Giegling, I, Mandelli, L, Schneider, B, Hartmann, AM, Schnabel, Aet al.NOS-I and -III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits. Am J Med Genet B Neuropsychiatr Genet. 147B 2008 42–48.CrossRefGoogle ScholarPubMed
Ryding, E, Lindström, M, Träskman-Bendz, LThe role of dopamine and serotonin in suicidal behaviour and aggression. Prog Brain Res 2008;172:307–315.CrossRefGoogle ScholarPubMed
Sarchiapone, M, Carli, V, Roy, A, Iacoviello, L, Cuomo, C, Latella, MCet al.Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients. Neuropsychobiology 2008;57:139–145.CrossRefGoogle ScholarPubMed
Sequeira, A, Mamdani, F, Lalovic, A, Anguelova, M, Lesage, A, Seguin, Met al.Alpha 2A adrenergic receptor gene and suicide. Psychiatry Res 2004;125:87–93.CrossRefGoogle ScholarPubMed
Suda, A, Kawanishi, C, Kishida, I, Sato, R, Yamada, T, Nakagawa, Met al.Dopamine D2 receptor gene polymorphisms are associated with suicide attempt in the Japanese population. Neuropsychobiology 2009;59:130–134.CrossRefGoogle ScholarPubMed
Tsai, SJ, Wang, YC, Hong, CJ, Chiu, HJAssociation study of oestrogen receptor alpha gene polymorphism and suicidal behaviours in major depressive disorder. Psychiatr Genet 2003;13:19–22.CrossRefGoogle ScholarPubMed
van den Oord, EJ, Kuo, PH, Hartmann, AM, Webb, BT, Möller, HJ, Hettema, JMet al.Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism. Arch Gen Psychiatry 2008;65:1062–1071.CrossRefGoogle ScholarPubMed
Zalsman, G, Frisch, A, Lewis, R, Michaelovsky, E, Hermesh, H, Sher, Let al.DRD4 receptor gene exon III polymorphism in inpatient suicidal adolescents. J Neural Transm 2004;111:1593–1603.CrossRefGoogle ScholarPubMed
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