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Lack of association between cholesterol blood levels and platelet serotonin uptake

Published online by Cambridge University Press:  16 April 2020

I Modai ,
A Valevski ,
L Kikinzon ,
Z Jerushalmy  and
A Weizman
I Modai
Affiliation:
Gehah Psychiatric Hospital, PO Box 102, 49100Petah Tiqva Felsenstein Medical Research Center, Beilinson Medical Center, Petah Tiqva Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
A Valevski
Affiliation:
Gehah Psychiatric Hospital, PO Box 102, 49100Petah Tiqva Felsenstein Medical Research Center, Beilinson Medical Center, Petah Tiqva Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
L Kikinzon
Affiliation:
Gehah Psychiatric Hospital, PO Box 102, 49100Petah Tiqva
Z Jerushalmy
Affiliation:
Felsenstein Medical Research Center, Beilinson Medical Center, Petah Tiqva Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
A Weizman
Affiliation:
Gehah Psychiatric Hospital, PO Box 102, 49100Petah Tiqva Felsenstein Medical Research Center, Beilinson Medical Center, Petah Tiqva Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Summary

It has been suggested that low serum cholesterol interferes with brain serotonergic functioning, which results in increased suicidal and aggressive tendencies. To test this hypothesis we investigated the relationship between serum cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglyceride levels, and serotonin uptake by blood platelets in 17 healthy men aged 39.5 ± 10.2 years. Platelet serotonin uptake and serum lipids were assayed concomitantly for each individual. Serum cholesterol levels and other serum lipid levels did not correlate with serotonin uptake by platelets at the concentration of 2 × 10−5 M (a concentration within the maximal uptake capacity range). The results indicate no influence of cholesterol on serotonin uptake, as opposed to some investigators who suggested that high risk of suicide and aggressiveness in hypocholesterolemic individuals is related to impaired serotonin transport.

Keywords

cholesterolserotoninuptake
Type
Original article
Information
European Psychiatry , Volume 10 , Issue 7 , 1995 , pp. 352 - 354
Copyright
Copyright © Elsevier, Paris 1995

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References

Barradas, MAMikhailidis, DPWinder, AFLow serum cholesterol and suicide. Lancet 1992; 39: 1168CrossRefGoogle Scholar
Brown, SLSalive, MEHarris, TBSimonsick, EMGuralnick, JMKohout, FJLow cholesterol concentrations and severe depressive symptoms in elderly people Br Med J 1994; 308: 1328–32Google ScholarPubMed
Dayton, SPearce, MLGoldman, H et al. Controlled trial of a diet high in unsturated fat for prevention of atherosclerotic complications Lancet 1968; 2 (577): 1060–2CrossRefGoogle Scholar
Engelberg, HLow serum cholesterol and suicide Lancet 1992; 339: 727–9CrossRefGoogle ScholarPubMed
Kaplan, JRManuck, SBThe effects of fat and cholesterol on aggressive behavior in monkeys Psychosom Med 1991; 53: 634–42CrossRefGoogle ScholarPubMed
Modai, IValevski, AShachar, DWeizman, ASerum cholesterol levels and suicidal tendencies in psychiatric inpatients J Clin Psychiatry 1994; 55: 252–4Google ScholarPubMed
Muldoon, MFManuck, SBMathews, KMLowering cholesterol concentrations and mortality; a quantitative review of primary prevention trials. Br Med J 1990; 301: 309–14CrossRefGoogle ScholarPubMed
Report from the committee of principal investigators. A cooperative trial in the primary prevention of ischaemic heart disease using clofibrate Br Heart J 1978; 40: 1069-118CrossRefGoogle Scholar
Rotman, ABlood platelets in psychopharmacological research Prog Neuropsychopharmacol Biol Psychiatry 1983; 7: 135–51CrossRefGoogle ScholarPubMed
Severs, NJLow serum cholesterol and suicide Lancet 1992; 339: 1001CrossRefGoogle ScholarPubMed
Virkkunen, MSerum cholesterol levels in homicidal offenders. Neuropsychobiol 1983; 10: 65–9Google ScholarPubMed
Virkkunen, MPenttinen, HSerum cholesterol in aggressive conduct disorder; a preliminary report Biol Psychiatry 1984; 19: 435–40Google Scholar
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