Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-17T18:29:37.714Z Has data issue: false hasContentIssue false
  • English
  • Français

Reduced immobility time in the tail suspension test (TST) by chronic immobilization stress. Role of corticosterone and brain serotonergic and adrenergic receptors

Published online by Cambridge University Press:  16 April 2020

E De Castro-e-Silva ,
MF Peres ,
P Brito ,
C Cobas ,
A Saraiva ,
V Silva ,
A Chaves ,
L Barros  and
IR De Oliveira
E De Castro-e-Silva
Affiliation:
Laboratório de Neurociêncas
MF Peres
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI), Departamento de Fisiologia e Farmacologia, Instituto de Ciências da Saúde, Universidade Federal de Bahia, 40140Salvador-Bahia, Brazil
P Brito
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI), Departamento de Fisiologia e Farmacologia, Instituto de Ciências da Saúde, Universidade Federal de Bahia, 40140Salvador-Bahia, Brazil
C Cobas
Affiliation:
Laboratório de Neurociêncas
A Saraiva
Affiliation:
Laboratório de Neurociêncas
V Silva
Affiliation:
Laboratório de Neurociêncas
A Chaves
Affiliation:
Laboratório de Neurociêncas
L Barros
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI), Departamento de Fisiologia e Farmacologia, Instituto de Ciências da Saúde, Universidade Federal de Bahia, 40140Salvador-Bahia, Brazil
IR De Oliveira*
Affiliation:
Grupo de Estudos em Neuropsiquiatria e Psicofarmacologia (GENPSI), Departamento de Fisiologia e Farmacologia, Instituto de Ciências da Saúde, Universidade Federal de Bahia, 40140Salvador-Bahia, Brazil
*
*Correspondence and reprints.
Get access

Summary

Chronically stressed adult male Balb C mice were submitted to the tail suspension test. Chronic immobilization stress (6 h/d for 14 consecutive days) induced a significant reduction in immobility time when compared to non-stressed controls. Pretreatment with LY 53857, a serotonin 5HT2 antagonist, and IPS 339, a selective beta-2 adrenoceptor blocker, reversed immobility time to the levels of non-stressed controls. Chronic administration of corticosterone (100 mg/kg for 7 d) did not modify immobility time as compared to saline treated controls. It is suggested that both serotonergic and adrenergic pathways in the brain may participate in the stress-induced changes occurring in the tail suspension test response and that corticosterone does not appear to play a role in this process.

Keywords

tail suspension teststressserotoninnoradrenalinecorticosterone
Type
Original article
Information
European Psychiatry , Volume 7 , Issue 5 , 1992 , pp. 235 - 238
Copyright
Copyright © Elsevier, Paris 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bliss, EL (1973) Effects of behavior manipulation upon brains serotonin and dopamineIn: Serotonin and Behavior (Barchasand, JDUsdin, E, eds) Academic Press, New York315–324Google Scholar
Cohen, MLColbert, WWittenauer, LA (1985) Receptor specificity of the 5HT2 antagonist, LY 53857. Drug Dev Res 5, 313–321CrossRefGoogle Scholar
De Oliviera, IRDiquet, BVan der Meersch, VDardennes, RGonidec, JPrado-lima, PAS (1990) Self-inhibiting action of nortryptyline's anti-immobility effect at high plasma and brain levels in mice. Psychopharmacology 102, 553–556CrossRefGoogle Scholar
De Oliviera, IRPrado-lima, PASSamuel-lajeunesse, B (1989) Monitoring of tricyclic antidepressant plasma levels and clinical response: A review of the literature. Psychiatr & Psychobiol 4, 43–60Google Scholar
Fuxe, KCorrodi, HHökfelt, TJonsson, G (1970) Central monoamine neurons and pituitary-adrenal activity. Prog Brain Res 32, 42–56CrossRefGoogle ScholarPubMed
Graeff, FG (1991) Neurotransmitters in dorsal periacqueductal gray and animal models of panic anxietyIn: New Concepts in Anxiety (Briley, MFile, SE, eds) MacMillan Press, London228–312Google Scholar
Hodges, HGreen, SGlenn, B (1987) Evidence that the amygdala is involved in benzodiazepine and serotoner gic effects on punished responding but not on discrimination. Psychopharmacology 92, 491–504CrossRefGoogle Scholar
Imbs, JLMiesch, FSchwartz, JVelly, J (1977) A potent new beta-2 adrenoceptor blocking agent. Br J Pharmacol 80, 357–362CrossRefGoogle Scholar
Korf, JAghajanian, GKRoth, RH (1973) Increased turnover of norepinerphrine in the rat cerebral cortex during stress: role of locus coeruleus. Neuropharmacology 12, 933–938CrossRefGoogle Scholar
Kvetnansky, RPalkovits, MMitro, ATorda, TMikulaj, L (1977) Catecholamines in individual hypothalamic nuclei of acutely and repeatedly stressed rats. Neuroendocrinology 23, 257–267CrossRefGoogle ScholarPubMed
Lecubrier, YPuech, AJJouvent, RSimon, PWidlocher, D (1980) A beta adrenergic stimulant (salbutamol) versus clomipramine in depression: a controlled study. Br J Psychiatry 136, 354–358Google Scholar
Martin, PSoubrie, PSimon, P (1986a) Shuttle-box deficits induced by inescapable shocks in rats: reversal by the beta-adrenoceptor stimulants clembuterol and salbutamol. Pharmacol Biochem Behav 24, 177–181CrossRefGoogle Scholar
Martin, PSoubrie, PSimon, P (1986b) Noradrenergic and opioid mediation of tricyclic-induced reversal of escape deficits caused by inescapable shock pre-treatment in rats. Psychopharmacology 90, 90–94CrossRefGoogle Scholar
Palkovits, MKobayashi, RMKaiser, JSJacobowits, DMKopin, IJ (1975) Effects of stress on catacholamines and tyrosine hydroxylase activity of individual hypothalamic nuclei. Neuroendocrinology 18, 144–153CrossRefGoogle Scholar
Petersen, ENSheel-Krueger, J (1984) Anticonflict effects of 5-HT antagonists by intraamygdaloid injection Abstr 14th CINP, 654Google Scholar
Rudorfer, MVPotter, WZ (1989) Antidepressants: a comparative review of the clinical pharmacology and therapeutic use of the “newer” versus the “older” drugs. Drugs 37, 713–738CrossRefGoogle ScholarPubMed
Steru, LChermat, RThierry, B (1985) The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology 85, 367–370CrossRefGoogle ScholarPubMed
Stone, EA (1970) Swim-stress induced inactivity relation to body temperature and norepinephrine and effects of d amphetamine. Psychosomat Med 32, 51–59CrossRefGoogle ScholarPubMed
Thierry, AMFekete, MGlowinski, J (1968) Effects of stress on the metabolism of noradrenaline, dopamine and serotonin (5-HT) in the central nervous system of the rat (II). Modification of serotonin metabolism. Eur J Pharmacol 4, 384–389CrossRefGoogle Scholar
Welch, BLWelch, AS (1970) Control of brain catecholamines and serotonin during acute stress and after damphetamine by natural inhibition of monoamine oxidase: An hypothesisIn: Amphetamines and Related Compounds (Costa, EGarattini, S eds) Raven Press, New York, 415–445Google Scholar
Zigmond, REShon, FIversel, LL (1974) Increased tyrosine hydroxylase activity in locus coeruleus of rat brain stem after reserpine treatment and cold stress. Brain Res 70, 547–552CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.