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Sinistrality in subtypes of schizophrenia

Published online by Cambridge University Press:  16 April 2020

Sonia Dollfus ,
Jacqueline A. Buijsrogge ,
Karim Benali ,
Pascal Delamillieure  and
Perrine Brazo
Sonia Dollfus*
Affiliation:
Groupe d’imagerie neurofonctionnelle (GIN), Unité mixte de recherche 6095, CNRS/CEA/Université de Caen/Université de Paris V and Centre Esquirol, Centre Hospitalier et Universitaire Caen, 14000 Caen, France
Jacqueline A. Buijsrogge
Affiliation:
Groupe d’imagerie neurofonctionnelle (GIN), Unité mixte de recherche 6095, CNRS/CEA/Université de Caen/Université de Paris V and Centre Esquirol, Centre Hospitalier et Universitaire Caen, 14000 Caen, France
Karim Benali
Affiliation:
Groupe d’imagerie neurofonctionnelle (GIN), Unité mixte de recherche 6095, CNRS/CEA/Université de Caen/Université de Paris V and Centre Esquirol, Centre Hospitalier et Universitaire Caen, 14000 Caen, France
Pascal Delamillieure
Affiliation:
Groupe d’imagerie neurofonctionnelle (GIN), Unité mixte de recherche 6095, CNRS/CEA/Université de Caen/Université de Paris V and Centre Esquirol, Centre Hospitalier et Universitaire Caen, 14000 Caen, France
Perrine Brazo
Affiliation:
Groupe d’imagerie neurofonctionnelle (GIN), Unité mixte de recherche 6095, CNRS/CEA/Université de Caen/Université de Paris V and Centre Esquirol, Centre Hospitalier et Universitaire Caen, 14000 Caen, France
*
*Corresponding author. E-mail address:dollfus-s@chu-caen.fr (S. Dollfus)
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Summary

Sinistrality, characterized by an excess of non-right-handedness, has been reported in schizophrenic patients, but the findings are controversial.

Aim.

As sinistrality could be linked to a failure of hemisphere specialization in schizophrenia that would translate into language disorders, sinistrality was found out in disorganized and positive schizophrenic patients characterized by language disorders.

Methods.

Seventy-three schizophrenic patients (DSM IV) and 81 controls were evaluated with the Edinburgh Handedness Inventory (EHI). Patients were evaluated and classified into five subtypes (deficit, positive, disorganized, mixed and residual) with the Positive and Negative Syndrome Scale and the Schedule for the Deficit Syndrome.

Results.

Disorganized patients had a significantly more severe sinistrality in comparison to the deficit, residual and mixed subtypes and controls. A negative correlation was found between the disorganization and the EHI scores (r = – 0.34; P < 0.01). A significantly more severe sinistrality was also observed in the positive subtype in comparison to controls, but there was no correlation between hallucinatory and EHI scores (r = 0.06).

Conclusion.

The findings provided further evidence that the defects in the normal process of lateralization observed in schizophrenia affects primarily disorganized patients.

Keywords

SinistralityLateralitySchizophreniaDeficitDisorganizedLanguage dominance
Type
Original article
Information
European Psychiatry , Volume 17 , Issue 5 , September 2002 , pp. 272 - 277
Copyright
Copyright © European Psychiatric Association 2002

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