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Association between childhood maltreatment and cortical folding in women with eating disorders

Published online by Cambridge University Press:  27 August 2024

R. Cerra ,
N. Attianese ,
M. Battipaglia ,
R. Ceres ,
S. Donato ,
A. M. Monteleone ,
P. Monteleone  and
G. Cascino
R. Cerra*
Affiliation:
1Department of Mental, Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples
N. Attianese
Affiliation:
1Department of Mental, Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples
M. Battipaglia
Affiliation:
1Department of Mental, Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples
R. Ceres
Affiliation:
1Department of Mental, Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples
S. Donato
Affiliation:
1Department of Mental, Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples
A. M. Monteleone
Affiliation:
1Department of Mental, Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples
P. Monteleone
Affiliation:
2Department of Medicine, Surgery and Dentistry, University of Salerno “Scuola Medica Salernitana”, Salerno, Italy
G. Cascino
Affiliation:
2Department of Medicine, Surgery and Dentistry, University of Salerno “Scuola Medica Salernitana”, Salerno, Italy
*
*Corresponding author.

Abstract

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Introduction

Childhood maltreatment (CM) is associated with distinct clinical and biologi- cal characteristics in people with eating disorders (EDs). The measurement of local gyrification index (lGI) may help to better characterize the impact of CM on cortical structure.

Objectives

The objective of this study was to investigate the association of CM with lGI in women with EDs.

Methods

Twenty-six women with anorexia nervosa (AN) and 24 with bulimia nervosa (BN) underwent a 3T MRI scan. All partici- pants filled in the Childhood Trauma Questionnaire. All neuroimaging data were processed by FreeSurfer. LGI maps underwent a general linear model to evaluate differences between groups with or without CM. People with AN and BN were merged together.

Results

Based on the Childhood Trauma Questionnaire cut- off scores, 24 participants were identified as maltreated and 26 as non- maltreated. Maltreated people with EDs showed a significantly lower lGI in the left middle temporal gyrus compared with non-maltreated people, whereas no differences emerged in the right hemisphere between groups.

Conclusions

The present study showed that in people with EDs, CM is associated with reduced cortical folding in the left middle temporal gyrus, an area that could be involved in ED psychopathology. This finding corroborates the hypothesis of a ‘maltreated ecophenotype’, which argues that CM may allow to biologically, other than clinically, distinguish individuals with the same psychiatric disorder.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 67 , Special Issue S1: Abstracts of the 32nd European Congress of Psychiatry , April 2024 , pp. S308
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of European Psychiatric Association
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