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Association between lymphocytes, hippocampus volume and depressive symptoms in drug – naïve First Episode Psychosis

Published online by Cambridge University Press:  01 September 2022

A. Toll ,
D. Bergé ,
K. El-Abidi ,
T. Legido ,
V. Pérez-Solà  and
A. Mané
A. Toll*
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
D. Bergé
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
K. El-Abidi
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
T. Legido
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
V. Pérez-Solà
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
A. Mané
Affiliation:
Parc de Salut Mar, Institut De Neuropsiquiatria I Addiccions, Barcelona, Spain
*
*Corresponding author.

Abstract

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Introduction

The role of the white blood cells, which form the peripheral immune system and are crucial in inflammatory processes, has been laid aside in the context of brain structural changes in schizophrenia.

Objectives

Determine how blood cells are associated with some brain structures volumes in first episode psychosis (FEP) and their relationship with clinical variables at baseline and 1 year follow – up.

Methods

Fifty drug-naïve FEP treated between April 2013 and July 2017 at the ETEP Program at Hospital del Mar were included. Inclusion criteria were: 1) age 18-35 years; 2) fulfillment of DSM-IV-TR criteria for brief psychotic disorder, schizophreniform disorder, schizophrenia or unspecified psychosis; 3) no previous history of severe neurological medical conditions or severe traumatic brain injury; 4) presumed IQ level > 80, and 5) no substance abuse or dependence disorders except for cannabis and/or nicotine use. All patients underwent an assessment at baseline and at one-year follow-up, including sociodemographic and clinical variables (substance use, DUP, PANSS, GAF and CDSS). Fasting blood samples were obtained before administering any medication at baseline. Structural T1 MRI was performed at baseline and brain volumes were quantified though FreeSurfer software. SPSS program was used for statistical analyzes.

Results

Lymphocytes have a positive correlation with right and left hippocampus at baseline. Moreover, lymphocytes have a negative correlation with depressive symptoms at baseline and 1 year follow – up.

Conclusions

Lymphocytes may have a protective effect in some brain structures in FEP patients at baseline, especially those implicated in depressive symptoms.

Disclosure

No significant relationships.

Keywords

LymphocytesFirst Episode PsychosisHippocampusschizophrénia
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S759 - S760
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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