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Association of D2 dopamine receptor and alcohol dehydrogenase 2 genes with Polynesian alcoholics

Published online by Cambridge University Press:  16 April 2020

S. Amadéo ,
E.P. Noble ,
M.L. Fourcade-Amadéo ,
C. Tetaria ,
M.F. Brugiroux ,
L. Nicolas ,
X. Deparis ,
A. Elbaz ,
X. Zhang  and
T. Ritchie
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S. Amadéo*
Affiliation:
Service de Psychiatrie Adulte, Hopital Vaiami, Papeete Tahiti, Polynésie, Française Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, CNRS, Batiment CERVI, Hôpital de la Pitié, Salpêtrière, Paris, France
E.P. Noble
Affiliation:
UCLA Neuropsychiatric Institute and Brain Research Institute, Los AngelesCA, USA
M.L. Fourcade-Amadéo
Affiliation:
CHT de Mamao et Centre de Transfusion Sanguine, Papeete Tahiti, Polynésie, Française
C. Tetaria
Affiliation:
CHT de Mamao et Centre de Transfusion Sanguine, Papeete Tahiti, Polynésie, Française
M.F. Brugiroux
Affiliation:
Service d'Alcoologie et Toxicomanie, Papeete Tahiti, Polynésie, Française
L. Nicolas
Affiliation:
Institut Territorial de Recherches Médicales Louis Malardé, Papeete Tahiti, Polynésie, Française
X. Deparis
Affiliation:
Institut Territorial de Recherches Médicales Louis Malardé, Papeete Tahiti, Polynésie, Française
A. Elbaz
Affiliation:
Inserm, Pointe à Pitre, Guadeloupe
X. Zhang
Affiliation:
UCLA Neuropsychiatric Institute and Brain Research Institute, Los AngelesCA, USA
T. Ritchie
Affiliation:
UCLA Neuropsychiatric Institute and Brain Research Institute, Los AngelesCA, USA
P.V. Martin
Affiliation:
Institut Territorial de Recherches Médicales Louis Malardé, Papeete Tahiti, Polynésie, Française
J. Mallet
Affiliation:
Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, CNRS, Batiment CERVI, Hôpital de la Pitié, Salpêtrière, Paris, France
*
*Correspondence and reprints
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Summary

Alleles of the D2 dopamine receptor (DRD2) and the alcohol dehydrogenase 2 (ADH2) genes were determined in 69 French Polynesian alcoholic patients and 57 controls matched for racial origin. Three racial groups were studied: pure Polynesians (PP), Polynesians mixed with Caucasian (PCA) ancestry and Polynesians mixed with Chinese (PCH) ancestry. DRD2 A1 allele frequencies in the alcoholics compared to their controls in these groups were: PP,.26 vs .32 (P = .69); PCA, .44 vs .35 (P = .46); PCH, .40 vs 0.39 (P = .88). ADH2 1 allele frequencies in alcoholics compared to their controls groups were: PP, .56 vs .62 (P = .66); PCA, .75 vs .56 (P = .09); PCH, .78 vs .32 (P = .009). In the PCA group, the combination of the DRD2 A1 genotypes and the ADH2 1 homozygotes was strongly associated with alcoholism (P = .0027). This preliminary study shows the importance of ascertaining racial ancestry in molecular genetic association studies. Moreover, it suggests that a combination of genes are involved in susceptibility to the development of alcoholism.

Keywords

ADHALDHDRD2alcoholismassociation studiesPolynesians
Type
Original Article
Information
European Psychiatry , Volume 15 , Issue 2 , March 2000 , pp. 97 - 102
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2000

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