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Changes of 5-HT1A receptor in the dorsal raphe nucleus in the rat model of Post-Traumatic Stress Disorder

Published online by Cambridge University Press:  16 April 2020

F.F. Luo ,
F. Han  and
X.Y. Shi
F.F. Luo
Affiliation:
China Medical University, Shenyang, China
F. Han
Affiliation:
China Medical University, Shenyang, China
X.Y. Shi
Affiliation:
China Medical University, Shenyang, China

Abstract

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Introduction

Posttraumatic stress disorder (PTSD) is characterized mainly by symptoms of reexperiencing, avoidance and hyperarousal as a consequence of catastrophic and traumatic events that are distinguished from ordinary stressful life events. Single-prolonged stress (SPS) is an established animal model for post-traumatic stress disorder (PTSD). The dorsal raphe nucleus (DR)-serotonin (5-HT) system is dramatically affected by swim stress and has been implicated in affective disorders. The 5-HT1A receptor (5-HT1AR) is critically involved in regulating mood and anxiety levels.

Objective

In this study, we investigated changes in the expression of 5-HT1AR in DR of rats after SPS which may reveal part of the pathogenesis of PTSD.

Methods

Rats were randomly divided into 24h, 4d and 7d groups after SPS and a normal control group, 5-HT1AR expression in DR was examined using immunohistochemistry, western blotting and reverse transcription polymerase chain reaction.

Results

The expression of 5-HT1AR in DR after SPS exposure was increased when compared to that in the control group (P < 0.05).

Conclusion

These findings suggest increase of 5-HT1AR in DR of SPS rats, which may play important roles in the pathogenesis of PTSD rats.

Type
P02-485
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 1081
Copyright
Copyright © European Psychiatric Association 2011
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