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Clinical dynamics of anhedonia symptom in mood disorder and in alcohol use disorder

Published online by Cambridge University Press:  13 August 2021

O. Roshchina ,
G. Simutkin  and
N. Bokhan
O. Roshchina*
Affiliation:
The Department Of Depressive States, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation
G. Simutkin
Affiliation:
The Department Of Depressive States, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation
N. Bokhan
Affiliation:
Deaprtment Of Psychological Counseling And Psychotherapy, National Research Tomsk State University, Tomsk, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Anhedonia is an important transdiagnostic phenotypic characteristic of schizophrenia, mood disorders (MD), alcohol use disorder (AUD) and other mental diseases. This Symptom could reflect the neurochemical abnormalities in addictive and affective disorders when the function of reward system is dysregulated (Koob G.F., 2017).

Objectives

To compare the severity of Anhedonia in clinic of MD and AUD in dynamic of antidepressant therapy

Methods

The study enrolled 93 patients under treatment in MHRI Clinics: 45 AUD (F10.2; ICD-10) and 48 MD patients (F31-F34; ICD-10). The evaluation of Anhedonia was provided with the SHAPS modified for clinician administration (SHAPS-C) (Rezvan A., 2014).

Results

Due to statistical analysis, we found the level of anhedonia in the MD group was higher than in the AUD group before the treatment. After four weeks of antidepressant therapy the scrutiny of score difference shows less changes in severity of the Symptom in the AUD group (Table 1) Table 1. Dynamics of Anhedonia in MD and AUD groups by SHAPS-C

GroupTotal score upon admissionTotal score after four weeks therapyTotal score upon admission and after four weeks therapy
AUD (n=45)24 (22; 27,5)22 (20,25; 28)1 (-3; 4)
MD (n=48)30 (23; 38)25 (20; 28)4 (1; 8)
р (Mann-Whitney test)0,0030,3730,002

Conclusions

Anhedonia in the structure of AUD is less pronounced than in MD, but responds less to antidepressant therapy. The study is supported by RSF Grant no. 19-15-00023 “Clinical features and search of potential biomarkers of comorbidity of alcoholism and affective disorders”.

Keywords

anhedoniamood disordersalcohol use disorder
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S241
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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