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Cognitive capability of individuals at risk with and without transition to psychosis

Published online by Cambridge University Press:  16 April 2020

M.O. Pflueger ,
U. Gschwandtner ,
J. Aston ,
G. Berger ,
S. Borgwardt ,
M. Drewe ,
M. D'souza ,
E. Rechsteiner ,
R.D. Stieglitz  and
A. Riecher-Roessler
M.O. Pflueger
Affiliation:
Department of Patient Psychiatry, University Hospital, Basel, Switzerland
U. Gschwandtner
Affiliation:
Department of Patient Psychiatry, University Hospital, Basel, Switzerland
J. Aston
Affiliation:
Department of Patient Psychiatry, University Hospital, Basel, Switzerland
G. Berger
Affiliation:
Department of Patient Psychiatry, University Hospital, Basel, Switzerland
S. Borgwardt
Affiliation:
Department of Patient Psychiatry, University Hospital, Basel, Switzerland
M. Drewe
Affiliation:
Department of Patient Psychiatry, University Hospital, Basel, Switzerland
M. D'souza
Affiliation:
Department of Patient Psychiatry, University Hospital, Basel, Switzerland
E. Rechsteiner
Affiliation:
Department of Patient Psychiatry, University Hospital, Basel, Switzerland
R.D. Stieglitz
Affiliation:
Department of Patient Psychiatry, University Hospital, Basel, Switzerland
A. Riecher-Roessler
Affiliation:
Department of Patient Psychiatry, University Hospital, Basel, Switzerland

Abstract

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Objectives

To compare neuropsychological functions of individuals at risk (IR) for psychosis and patients with a first episode of psychosis (FE) with healthy control subjects (HC). And to determine cognitive factors which have the potential to discriminate IR with (IRtrans) and without (IRnon-trans) transition to psychosis.

Methods

N = 60 prodromal IR and N = 51 healthy control subjects were assessed with a comprehensive neuropsychological test battery. Besides general intelligence the test battery covered two functional domains (executive and attentional functions) and working memory. Within a follow up period of at least 30 month N = 19 IR transited to psychosis and N = 30 IR still have been followed up.

For each patient group (FE and IR), cognitive profiles were constructed by means of z-values adjusted for demographic and medication influence. The HC mean performance level was used as baseline of each group profile. A further profile was constructed by differential values considering IRtrans versus IRnon-trans. Comparisons were carried out by MANOVA and post- hoc t-tests.

Results

In all functional domains FE and IR performed below HC except for specific sustained attention measures. There were no significant differences between FE and IR.

Executive functions and working memory measures were more compromised in IRtrans as compared to IRnon-trans.

Conclusions

Neuropsychological deficiencies precede psychotic breakdown. This indicates that neuropsychological assessments of affected domains may support early detection of psychosis.

Type
S18. Symposium: Can we Improve the Prediction of the Onset of Psychosis
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S30
Copyright
Copyright © European Psychiatric Association 2007
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