No CrossRef data available.
Article contents
Comparison of Val66met Polymorphism of BDNF gene in patients of bipolar disorder and healthy controls.
Published online by Cambridge University Press: 27 August 2024
Abstract
Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction
The study aims to explore the utility of BDNF Val66Met polymorphism as a potential biomarker in Indian bipolar disorder patients and its correlation with clinical characteristics.
Objectives
Genotyping Val66Met in BDNF gene
Exploring its association with bipolar disorder (BD).
Methods
150 consenting BD patients and matched controls were recruited using a case-control study design. BD severity was assessed using Young’s mania rating scale and the Clinical Global Impression - Severity (CGI-S) scale. BDNF Val66Met polymorphism was identified through real-time PCR after DNA extraction. Data was tested for normal distribution. Genotype frequencies between two groups were compared and the Hardy-Weinberg equilibrium assumptions were tested using Chi-Square tests. Clinical-genotypic associations were explored using the Kruskal-Wallis test and confirmed using hierarchical regression.
Results
Table 2.
Table 3.
Our sample had more males (60%) than females (40%) with mean age of 35.05 years. Most patients had established bipolar disorder and were severely ill (CGI: 38.75, YMRS). Val66Met SNP genotype frequency differed significantly between cases and controls. Val66Val genotype and Val allele were higher in cases. Results consistent with Hardy-Weinberg equilibrium.Table 1.
Genotype frequencies of BDNF (rs6265) in cases and controls
| GENOTYPE | |||
|---|---|---|---|
| CC | CT | TT | |
| CASES | 94(62.6%) | 47(31.3%) | 9(6%) |
| CONTROL | 71(47.3%) | 69(46%) | 10(6.6%) |
| CHI-SQUARE- 7.431 | DF(Degree of freedom) - 2 | p-value- 0.024 | |
Dominant genotype frequencies in cases and controls
| DOMINANT GENOTYPE | ||
|---|---|---|
| CC | CT+TT | |
| CASES | 94(62.6%) | 56(37.3%) |
| CONTROLS | 71(47.3%) | 79(52.6) |
| CHI-SQUARE-7.125 | DF(Degree of freedom)-1 | p-value-0.007 |
Allelic frequencies of BDNF (rs6265) in BD cases and healthy controls
| ALLELIC VARIATION | ||
|---|---|---|
| C | T | |
| CASES | 235(78.3%) | 65(21.6%) |
| CONTROLS | 211(70.3%) | 89(29.6%) |
| CHI-SQUARE-5.032 | DF(Degree of freedom)-1 | p-value- 0.024 |
Conclusions
Our study found that Val66Val genotype and Val allele were higher in cases and could be a potential biomarker for bipolar disorder (BD), which is consistent with previous research conducted on the European population. However, further investigations are required to gain a more comprehensive understanding of its impact on BD, including its association with serum BDNF levels, treatment outcomes, and a more diverse study population.
Disclosure of Interest
None Declared
- Type
- Abstract
- Information
- European Psychiatry , Volume 67 , Special Issue S1: Abstracts of the 32nd European Congress of Psychiatry , April 2024 , pp. S335 - S336
- Creative Commons
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.- Copyright
- © The Author(s), 2024. Published by Cambridge University Press on behalf of European Psychiatric Association
You have
Access
Open access
Comments
No Comments have been published for this article.