It is well-known that the depression is a disorder which is with the crossroads of biological and the psychic one, of social of cultural and the spiritual one. Our reflexion today, will try to throw the light, through our characteristic lived of looking after, on the aspect certainly, most occult, but which remains nevertheless in our humble opinion, more determining in the success of the project of care between the therapeutist and his suicidal patient, in other words: the cultural and spiritual dimension of this meeting. It Would not be not convenient, even advantageous, that the therapeutist takes the risk to explore of advantage the quotient of religiosity of his patient, with the detriment or not of his own convictions, in order to better help it in his spiritual storm; in other world. Can the spiritual accompaniment" it form part of the therapeutic contract? It is on its same interrogations, that will try to focus our reflexion, today. This naturally leads us to wonder the following questions: That of the bond which can exist between faith and psychic imbalance on the one hand. As of the interest which can draw looking after it, by integrating the spiritual life of its depressed patient, in his psychotherapy intention, on the other hand.