Antinociceptive activity of Olanzapine was demonstrated in animals and is a useful drug in controlling of aggression. This study evaluated the efficacy of this drug in treatment of patients that were dependant to Opioids (Opium and Heroin) and had Antisocial Personality Disorder.

During 6 month (2004) study 36 cases with Opioids substances dependency evaluated and 24 of them introduced as main study group with Antisocial Personality Disorder. Clinical interview and MMPI-2 test has been used in this process. All patients received clonidine and analgesics and 12 of them received Olanzapine10-30 mg/day. Patients evaluated after one month of treatment.

Compliance for treatment during One month was better (10 of 12 cases = 83.3%) in cases that have been received Olanzapine than versus group (4 of 12 cases = 33.3% P < 0.05). Frequently reported symptoms in second group were irritability (100%), verbal and physical hostility (100%, 84%) and restlessness (100%).

In patients with Opioids dependency and concomitant Antisocial Personality Disorder usefulness of Olanzapine may be in focus of attention in new researches. This drug improves the compliance of treatment especially in acute withdrawal phase.