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EPA-0140 – Antidepressants, Cbt, and Their Combination in Depressed Patients: A Systematic Review and Meta-analysis

Published online by Cambridge University Press:  15 April 2020

J. Wallace ,
M. Clarke ,
C. Byrne  and
B. Nwosu
J. Wallace
Affiliation:
OUDCE, Oxford University, Oxford, United Kingdom
M. Clarke
Affiliation:
OUDCE, Oxford University, Oxford, United Kingdom
C. Byrne
Affiliation:
Psychiatry, HSE, Roscommon, Ireland
B. Nwosu
Affiliation:
Early Intervention in Psychosis, Royal College of Surgeons, Dublin, Ireland

Abstract

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Background:

The comparative effectiveness of antidepressant medication and cognitive-behaviour therapy for the acute treatment of depression is contentious.

Objective:

To compare the acute outcomes of antidepressant medication, cognitive-behaviour therapy (CBT), and the combination of the two, in adult, depressed patients.

Methods:

Sixteen electronic databases together with reference lists were searched for randomised and other clinical trials that compared CBT, antidepressants, or their combination.

Results:

In the comparison between CBT and antidepressants, 8 studies met inclusion criteria. Five studies met the inclusion criteria for the second comparison between single therapy and combination therapy. In the antidepressant and CBT comparison, effect sizes favoured CBT over antidepressants with a significant advantage for CBT on some outcome measures. Combined treatment appeared more effective than antidepressants. However, combined treatment did not emerge more effective than CBT.

Conclusions:

Antidepressants may not be considered more efficacious than CBT for the acute treatment of depressed patients nor can combination therapy be regarded as more effective than CBT alone.

Type
FC03 - Free Communications Session 03: Affective disorders
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
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