The new conceptual ethiopathogenic model of schizophrenia was developed. The analysis more then 1000 references on a schizophrenia problem was examined. Also 350 schizophrenic patientsand 250 patients with a psychoorganic pathology stipulated diffuse and localcerebral defeats are subjected complex clinico-pathological, instrumental andbiochemical investigation. The analysis of literary dates has shown, that the intrinsic performance pathological signs for want ofschizophrenia consists in pathological violations of a mental orb. Independentof theoretical premises and methodological base all contributors unequivocally describe a pathology of a mental orb in frameworks of enough specific violation of thinking, orbs of perceptions and is emotional - affective orbs. Actually violation of processes of an informationinside an information system, which is represented by a mental orb of eachperson and interaction mechanisms with visible information space. On the order hand, morphofunctional changing of brain, have not specific character and can not cause violations of information processes. The clinical observations had shown, that the principle difference isnot only in psychopathological structure of syndromes, but also included pathopsychological mechanisms. In a structure of the psychopathological signs there was connection with structurally functional cerebral defeats. In a structure schizophrenia signs such connection is not present, and attempt to find it have a frankly speculativecharacter. The structural analysis signs of schizophrenia and its changes testifies to progressing dynamic violation of process of information processing. It has enabled to justify the concept ethiopathogenic of schizophrenia owing to existence of information viruses). In this occasion new psychotherapeutic psychopharmacological correctional complex were established.