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EPA-1229 – Comparison of The Saccadic Refixation Parameters in Patients Treated with Methadone and Individuals From The Control Group

Published online by Cambridge University Press:  15 April 2020

J. Feit ,
E. Nowinska ,
P. Walecki ,
W. Lason ,
M. Kunc  and
E.J. Gorzelanczyk
J. Feit
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland
E. Nowinska
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland
P. Walecki
Affiliation:
Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
W. Lason
Affiliation:
Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
M. Kunc
Affiliation:
Faculty of Medicine, University of Leeds, Leeds, United Kingdom
E.J. Gorzelanczyk
Affiliation:
Department of Theoretical Basis of Bio-Medical Sciences and Medical Informatics. Institute of Philosophy, Nicolaus Copernicus University Collegium Medicum. Kazimierz Wielki University. Non-public Health Care Center Sue Ryder Home, Bydgoszcz, Poland

Abstract

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Introduction:

Administration of psychoactive drugs increases dopaminergic receptor stimulation, improves mood and stimulates motor activity. Structural and functional changes can be observed in particular structures of the central nervous system (CNS).

Aims/Objectives:

This study aims to assess the saccadic refixation parameters in opioid addicted subjects treated with methadone compared to control group.

Methods:

Eighty-six patients from the substitution program were examined. The study included 36 subject of the control group. The trial was conducted twice: before and about 1.5 hours after the administration of therapeutic dose of methadone. Performed Latency Test(LT) with Saccadometr diagnostic system.

Results:

The statistical analysis showed that the mean duration before and after the administration of methadone was a statistically significant increases (p=0,0001) in the subjects from substitution program compared of the control group but after administration of methadone the value greatly increased in experimental group (before 52ms, after 56ms). It was observed that the mean amplitude after the administration of methadone increased statistically significantly in experimental group compared of the control group (p=0,02). Mean peak velocity of latency after the administration of a therapeutic dose of methadone was statistically significant decreased in experimental group compared of the control group (p=0,0004).

Conclusion:

The results indicate a change in the dynamics of saccade after methadone administration. The observed changes in values for eye movements may be due to the inhibitory effect of methadone on CNS.

Type
EPW18 - Addictive Behaviours 2
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
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