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Fatal interaction between tranylcypromine and imipramine

Published online by Cambridge University Press:  16 April 2020

Wim Otte ,
Tom K. Birkenhager  and
Walter W. van den Broek
Wim Otte
Affiliation:
Emergis Centre for Mental Health, Goes, The Netherlands
Tom K. Birkenhager*
Affiliation:
Department of psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Walter W. van den Broek
Affiliation:
Department of psychiatry, Erasmus Medical Centre, Dr. Molewaterplein 403015GD, Rotterdam, The Netherlands
*
2Corresponding author. Present address: Dept. of Psychiatry, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, the Netherlands. t.k.birkenhager@azu.nl
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Extract

This case report describes a patient on tranylcypromine who erroneously received a single dose of imipramine and subsequently developed a fatal serotonin syndrome. Both the clinical features and the pathophysiology of the serotonin syndrome are discussed.

Keywords

TranylcypromineImipramineDepressionSerotonin syndrome
Type
Case report
Information
European Psychiatry , Volume 18 , Issue 5 , August 2003 , pp. 264 - 265
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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References

Ananth, J, Luchins, D.A review of combined tricyclic and MAOI therapy. Compr Psychiatry 1977;18:221–30.CrossRefGoogle ScholarPubMed
Berlanga, C, Ortega-Soto, HA. A 3–year follow-up of a group of treatment depressed patients with a MAOI/tricyclic combination. J Affect Disord 1995;34:187–92.CrossRefGoogle ScholarPubMed
Marley, E, Wozniak, KM.Clinical and experimental aspects of interactions between amine oxidase inhibitors and amine re-uptake inhibitors. Psychol Med 1983;13:735–49.CrossRefGoogle ScholarPubMed
Nies, A, Robinson, DS.Monoamine oxidase inhibitors. In: Paykel, ES, editor. Handbook of affective disorders. Edinburgh: Churchill Livingstone; 1982. p. 246–61.Google Scholar
Sethna, ER. A study of refractory cases of depressive illness and their response to combined antidepressant treatment. Br J Psychiatry 1974; 124:265–72.CrossRefGoogle Scholar
Sternbach, H. The serotonin syndrome. Am J Psychiatry 1991;148: 705–13.Google ScholarPubMed
White, K, Simpson, G.Combined MAOI-tricyclic antidepressant treatment: a re-evaluation. J Clin Psychopharmacol 1981;1:264–82.CrossRefGoogle Scholar
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