Depression stands out as an important health issue that affects the entire family.

to assess the prevalence and level of depression and its relationship with autoantibodies, individual, environmental, laboratory and lifestyle parameters in miscarriage-patients

to evaluate the causes or effects of depression in recurrent miscarriage-patients.

50 variables containing sociodemographics, health-related habits, depression, serum molecules and blood parameters were evaluated in recurrent miscarriage-patients and healthy women with natural childbirth.

Although no significant differences for 4 sociodemographic and 18 health-related lifestyle parameters were found between patients and controls but depression score and its prevalence was higher in patients than controls. Depression scores were higher in miscarriage-patients (ranging 3–36, mean = 11.92 ± 1.37) than controls (ranging 0–8, mean = 3.05 ± 0.63) which 80.96% of them had no or mild, 2.38% mild-moderate, 4.76% moderate and 11.9% severe depression. There was also a significant association between anti-double-stranded-DNA-antibody (anti-dsDNA) or rheumatoid-factor (RF) level and depression in miscarriage-patients. Interestingly, depression score was inversely correlated with the level of soluble-leptin-receptor (sLeptinR) and soluble-glyeoprotein-130 (sgp130) after controlling for covariates in patients. Depression of miscarriage-patients was correlated with hookah consumption rate. Surprising that, the association between abortion histories and depression in miscarriage-patients become not significant after controlling for age.

Depression score and its prevalence are higher in miscarriage-patients than controls. The depression levels are correlated with certain autoantibodies such as anti-dsDNA or some habits like hookah smoking in miscarriage-patients. Inverse association between depression and some soluble molecules like sgp130 or sLeptinR in recurrent miscarriage-patients also remained to be elucidated.