WHO defines Sexual Health as “a state of physical, emotional, mental and social well-being in relation to sexuality… and requires a positive and respectful approach to sexuality and sexual relationships, as well as the possibility of having pleasurable and safe sexual experiences, free of coercion, discrimination and violence”.

OCD-10 defines Transsexualism as “the desire to live and be accepted as a member of the opposite sex, usually accompanied by the wish to make his or her body as congruent as possible with the preferred sex through surgery and hormone treatment. The transsexual identity has been present persistently for at least two years. The disorder is not a symptom of another mental disorder or a chromosomal abnormality”.

We developed an integrative model in 4 axes to approach Sexual Health concept and Transsexualism.

Holistic and integrative model of transsexualism gives a better understanding of this disorder and ameliorates global treatment. Moreover, this model should be applied to each sexual minority.

1. Etiology integrates psychological, biological and neuro-developmental aspects. 2. Clinical features for treatment imply large and multidisciplinary approach. 3. Scientific literature includes more than thousand papers on Transsexualism and numerous expertises as endocrinology, psychiatry, cardiology, sleep… 4. Social networks are developed in hospitals, associations… as well as between patients themselves.

Holistic and integrative approach of Sexual Minority as Transsexualism could reach Sexual Health concept defined by WHO.

The authors have not supplied their declaration of competing interest.