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The Influence of Depression in the Evolution of Parkinson’s Disease: A Psychiatric Perspective

Published online by Cambridge University Press:  27 August 2024

A. H. I. Abu Shehab ,
T. Simona ,
I. A. Ciureanu ,
D. C. Voinescu ,
L. Burlea  and
A. Ciubară
A. H. I. Abu Shehab*
Affiliation:
1Psychiatry Department, “Elisabeta Doamna” Psychiatric Hospital, Galati
T. Simona
Affiliation:
2Psychiatry Department, Carol Davila University of Medicine and Pharmacy, Bucharest
I. A. Ciureanu
Affiliation:
3Director of Communication Center, University of Medicine and Pharmacy “Grigore T. Popa”, Iași
D. C. Voinescu
Affiliation:
4Rheumatology department, “Dunărea de Jos” University - Faculty of Medicine and Pharmacy, Galati
L. Burlea
Affiliation:
5Technology, Prothesis and Implantology, University of Medicine and Pharmacy “Grigore T. Popa”, Iași
A. Ciubară
Affiliation:
6Psychiatry Department, “Dunărea de Jos” University - Faculty of Medicine and Pharmacy, Galati, Romania
*
*Corresponding author.

Abstract

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Introduction

Parkinson’s disease (PD) is a neurodegenerative condition that is predominantly characterised by its motor symptoms. Nevertheless, it is important to note that non-motor symptoms, particularly depression often occur concurrently, exerting a substantial influence on the progression of the disease and the overall well-being of individuals affected by it.

Objectives

The objective of this study is to examine the influence of depression on the advancement of Parkinson’s disease (PD) from a psychiatric perspective. This analysis will involve an assessment of the common neurobiological pathways involved and the potential implications for clinical treatment and care.

Methods

A comprehensive assessment of the literature was conducted, focusing on clinical observations, neurochemical interactions, and neuroimaging investigations that provide insight into the concurrent presence of depression and Parkinson’s disease (PD). This study aimed to investigate the potential impact of depression on the severity of Parkinson’s disease symptoms, the course of the disease, and the responsiveness to treatment.

Results

Depression in Parkinson’s disease (PD) is not only a reactive occurrence, but rather it may be attributed to common pathophysiological mechanisms, such as changes in dopamine and serotonin pathways. The coexistence of depression among individuals with Parkinson’s disease (PD) has been linked to heightened severity of motor and cognitive symptoms, accelerated development of the disease, and diminished effectiveness of therapy interventions. Furthermore, the presence of depression in individuals with Parkinson’s disease intensifies the psychosocial difficulties experienced by both patients and their carers.

Conclusions

The recognition and management of depression in individuals with Parkinson’s disease (PD) is of utmost importance in order to enhance treatment approaches and enhance the overall well-being of patients. The establishment of interdisciplinary collaboration between neurologists and psychiatrists is necessary in order to guarantee a holistic approach to patient care.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 67 , Special Issue S1: Abstracts of the 32nd European Congress of Psychiatry , April 2024 , pp. S302
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of European Psychiatric Association
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