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Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence
Published online by Cambridge University Press: 16 April 2020
Abstract
In a modified case–control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human μ-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence.
In contrast to classical case–control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the “Dangerous Drugs Act” in Germany.
For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence.
Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case–control association studies of opioid dependent individuals.
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- Copyright © Éditions scientifiques et médicales Elsevier SAS 2003
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