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Lymphocytic colitis in the course of a treatment with sertraline. A case report

Published online by Cambridge University Press:  01 September 2022

A. Cerame ,
A. Cotillas ,
P. Coucheiro  and
A. Franco Soler
A. Cerame*
Affiliation:
Hospital Universitario José Germain, Hospital De Día, Leganes, Spain
A. Cotillas
Affiliation:
Centro de Salud San Blas, Family Medicine, Parla, Spain
P. Coucheiro
Affiliation:
Hospital Universitario José Germain, Hospital De Día, Leganes, Spain
A. Franco Soler
Affiliation:
Hospital Universitario José Germain, Hospital De Día, Leganes, Spain
*
*Corresponding author.

Abstract

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Introduction

Lymphocytic colitis is an unusual side-effect of the treatment with SSRIs particularly sertraline. According to several sources, this side effect could be underdiagnosed and underreported.

Objectives

We present the case of a 31-year-old female patient who presented watery non-bloody diarrhea for a month. The patient had been diagnosed with Persistent Depressive Disorder six years prior to the episode and was being treated with sertraline.

Methods

A case report is presented alongside a review of the relevant literature regarding Lymphocytic colitis, its differential diagnosis and treatment.

Results

The case was coordinated between the out-patient psychiatry department and the patient’s Family Medicine specialist. The patient underwent a complete panel of tests including blood and stool test, and colonoscopy. The biopsy showed results compatible with the aforementioned diagnosis. Since the only pharmacological treatment which could cause or trigger lymphocytic colitis was sertraline, it was removed and treatment with oral budesonide was started with good results.

Conclusions

Lymphocytic colitis in the context of the treatment with SSRIs, particularly sertraline, is a side-effect which is more prevalent than what was thought in the past. A close coordination between psychiatrists and GP is of vital importance for the adequate treatment of mental health problems and treatment’s side-effects. It is important to bear in mind this possible side-effect to increase patient’s safety.

Disclosure

No significant relationships.

Keywords

lymphocytic colitisside-effectsertraline
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S715 - S716
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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