Disulfiram is one of most important drug in the treatment of alcoholics. Oral form of disulfiram was found 60 years ago. Subcutaneous form is in use more than 30 years. There are a lot of studies with dilemma is it effective therapy or placebo. We tried to elucidate this problem. We analyzed 36 alcoholics who implanted Disulfiram during one-year (2004.). We follow those patients during next two years (2005. and 2006.). During this more than two years period, 26 patients (72%) were in total abstinence, 6 patients (17%) were in abstinence more than one year and only 4 patients (11%) had abstinence less than one year. Social-demographic characteristics of patients with Disulfiram implant were: age between 31 and 40 years (36%), male (94%), with secondary education (61%), who live in town (53%), married (53%) and with agreement for hospital treatment (high motivation) (69%). We conclude that Disulfiram implant is very effective therapy, because ¾ of all implanted patients have longer abstinence than two years, related the standard oral therapy of Disulfiram (max. 60% patients have abstinence longer than one year).