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P0248 - A family case study on schizophrenia and bipolar disorder: Genotype and Cognition
Published online by Cambridge University Press: 16 April 2020
Abstract
Schizophrenia and bipolar disorder represent serious mental disorders with polygenic inheritance. Neurocognitive deficits have been linked to psychotic phenomena and are candidate endophenotype for the illness. We have analyzed the case of a family consisting of mother diagnosed with bipolar disorder, a daughter with schizophrenia and one free of psychiatric disorders. The genetic associations between a functional polymorphism in the MTHFR, COMT, APOE and MnSOD genes and cognition have been investigated. Genotyping was carried out using a PCR-RFLP method. Neuropsychological tests regarding executive functions (WCST, TMT-B), memory (RAVLT), attention (TMT-A) and phonetic and semantic verbal fluency have been applied. No significant association was found.
- Type
- Poster Session I: Schizophrenia and Psychosis
- Information
- European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S153 - S154
- Copyright
- Copyright © European Psychiatric Association 2008
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