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P0308 - Serotonin receptor 1a, 2a, 2c and CONT SNPs and personality traits in suicide attempters and controls

Published online by Cambridge University Press:  16 April 2020

R. Calati ,
A. Serretti ,
I. Giegling ,
A.M. Hartmann ,
H.J. Möller ,
C. Colombo  and
D. Rujescu
R. Calati
Affiliation:
Institute of Psychiatry, University of Bologna, Bologna, Italy
A. Serretti
Affiliation:
Institute of Psychiatry, University of Bologna, Bologna, Italy
I. Giegling
Affiliation:
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
A.M. Hartmann
Affiliation:
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
H.J. Möller
Affiliation:
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
C. Colombo
Affiliation:
Psychiatry Department, San Raffaele Scientific Institute, Milan, Italy
D. Rujescu
Affiliation:
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany

Abstract

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Background:

Serotonin and dopamine neurotransmitters have been extensively studied in association with temperamental and character traits.

Objective:

In the present study we considered the association between 1A, 2A and 2C serotonin receptor and COMT SNPs and personality traits, as measured by the Temperament and Character Inventory (TCI), in a sample of suicide patients and controls. The SNPs considered were for 1A receptor rs1423691, rs878567 and rs6295, for 2A receptor rs643627, rs594242, rs6311 and rs6313, for 2C receptor rs547536, rs2192372, rs6318, rs2428707, rs4272555 and rs1801412, and for COMT rs737865, rs4680 and rs165599.

Methods:

The sample was composed of three groups: two German samples, consisting of a healthy control group of 289 subjects (42.6% males, mean age: 45.2±14.9) and a psychiatric patient group of 111 suicide attempters (38.7% males, mean age: 39.2±13.6), and an Italian sub-sample, composed of 70 mood disorder patients (44.3% males, mean age: 42.9±14.4).

Results:

Controlling for sex, age and educational level, single markers and haplotypes were not or only marginally associated with personality dimensions.

Conclusions:

Our study does not support 1A, 2A, 2C and COMT role on personality traits.

Type
Poster Session I: Biological Markers
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S171 - S172
Copyright
Copyright © European Psychiatric Association 2008
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