Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system. the variety and unpredictability of the course of the disease leads to decreased quality of life as well as various psychological reactions, including anxiety disorders and depression.

A 55-years-old women with a 10 years history of MS was admitted to the psychiatric ward with anxiety, unjustified fear of the future, memory deterioration, drowsiness, weeping and debility in pleasure sensation. the patient suffers from paresthesia, has a right side hemiparesis. She walk susing support. Several neuropsychological tests were done. Tests and examination allowed to reach the diagnosis of organic anxiety disorder. the second patient is a 51-years-old male with 25 years history of MS was admitted to the psychiatric ward with low mood, low self-esteem, problems with concentration, loss of interest and pleasure in normally daily activities and weeping for a few years. His main problem were has suicidal thoughts he had for a few years. the patient suffers from stiffness of muscle, sometimes he has a little problems with walking but he moves by yourself. Patient's symptoms indicate depression.

The cases show that MS can have a different course. the first patient has a dominance of motion disorders, while second has a dominance of mental disorders. there also is a serious need in differentiation anxiety disorders with depression. the exact diagnosis allow to deal better with symptoms of MS and get better quality of the patients life.