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Peripheral Edema associated with Olanzapine: case report

Published online by Cambridge University Press:  19 July 2023

H. Jemli ,
Y. Zgueb  and
R. Zaibi
H. Jemli*
Affiliation:
1Psychiatry deparment A, Razi Hospital, Manouba, Tunisia
Y. Zgueb
Affiliation:
1Psychiatry deparment A, Razi Hospital, Manouba, Tunisia
R. Zaibi
Affiliation:
2Psychiatry deparment A, Razi Hospital, Manouba
*
*Corresponding author.

Abstract

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Introduction

Olanzapine is a second generation antipsychotic. Sedation and weight gain are common treatment side effects. However, other rare side effects such as peripheral edema are yet to be documented.

Objectives

Our study aimed to describe the clinical presentation of edema in a patient taking Olanzapine.

Methods

Case report

Results

We present the case of a 42 male patient hospitalized for a manic episode. He was put on Olanzapine at 10 mg a day. During the hospitalization, the patient exhibited profuse pitting edema on his lower limbs and a rapid weight gain. He presented no other physical sign such as a fever, cutaneous lesions or trouble walking. Thrombophlebitis and erysipelas were eliminated after an extensive physical exam, complete blood work and doppler ultrasound exam of both legs.

Olanzapine was discontinued and the patient was prescribed a 4-day course of loop diuretics. Complete resolution of symptoms was noted 5 days later.

Conclusions

Further research regarding the mechanism behind edema in patients taking second generation antipsychotics are needed. We recommend monitoring for edema with initiation and titration of Olanzapine treatment.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S183
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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