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Protective effect of curcumin on diazepam-induced behavioral changes and oxidative stress in rats

Published online by Cambridge University Press:  23 March 2020

A. Sevastre-Berghian ,
V. Făgărăşăn ,
N. Decea ,
R. Moldovan ,
B. Sevastre ,
M. Tăulescu  and
A.G. Filip
A. Sevastre-Berghian*
Affiliation:
University of Medicine and Pharmacy “Iuliu Hatieganu”, Physiology, Cluj-Napoca, Romania
V. Făgărăşăn
Affiliation:
University of Medicine and Pharmacy “Iuliu Hatieganu”, Physiology, Cluj-Napoca, Romania
N. Decea
Affiliation:
University of Medicine and Pharmacy “Iuliu Hatieganu”, Physiology, Cluj-Napoca, Romania
R. Moldovan
Affiliation:
University of Medicine and Pharmacy “Iuliu Hatieganu”, Physiology, Cluj-Napoca, Romania
B. Sevastre
Affiliation:
University of Agricultural Science and Veterinary Medicine, Faculty of Veterinary Medicine, Pathophysiology, Cluj-Napoca, Romania
M. Tăulescu
Affiliation:
University of Agricultural Science and Veterinary Medicine, Faculty of Veterinary Medicine, Morphopathology, Cluj-Napoca, Romania
A.G. Filip
Affiliation:
University of Medicine and Pharmacy “Iuliu Hatieganu”, Physiology, Cluj-Napoca, Romania
*
*Corresponding author.

Abstract

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Introduction

Curcumin (CUR), a polyphenolic compound, extracted from Curcuma longa, is known for its neuroprotective, antioxidant and anti-inflammatory effects.

Objectives

To evaluate the effect of CUR on ambulatory activity, spatial working memory and on oxidative stress in rats induced by Diazepam (DZP) administration.

Aims

To analyze whether CUR may improve the cognitive performance and offer systemic protection from oxidative stress.

Methods

The effect of CUR on DZP-induced memory impairment and oxidative stress was studied on Wistar rats. Group I received a vehicle, group II – vehicle and CUR, group III – vehicle and DZP, group IV – vehicle, CUR and DZP. CUR (150 mg/kg bw) and vehicle were orally administered for five weeks long. DZP (2 mg/kg bw) was administered i.p. 20 minutes before the behavioral tests. Behavioral tests, i.e. Open Field and Y Maze Test, were performed. Malondialdehyde and reduced glutathione/oxidized glutathione ratio were determined in the serum and brain tissue homogenate. Hippocampal sections were histologically assessed. The data were statistically analyzed by one-way ANOVA, followed by Dunns post-test.

Results

DZP decreased (P < 0.01) the number of spontaneous alternations, as compared to control group, thus suggesting an impairment of spatial working memory. Behavioral tests revealed no enhancing effect of CUR on spontaneous alternation behaviors in Y Maze. CUR reversed (P < 0.01) the inhibitory effect of diazepam (P < 0.05) on the ambulatory activity in OFT and decreased the lipid peroxidation in the serum (P < 0.05).

Conclusions

The results show that CUR may offer systemic protection from oxidative stress, thus improving the cognitive performance.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW650
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. s286
Copyright
Copyright © European Psychiatric Association 2014
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