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QTc interval in patients diagnosed with schizophrenia receiving different defined daily dose (DDD) of antipsychotics
Published online by Cambridge University Press: 23 March 2020
Abstract
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Introduction
Both 1st and 2nd generation of antipsychotics are associated with prolonged QTc interval. Prolonged QTc can lead to ventricular tachycardia and Torsade's de pointes, ultimatime resulting to cardiac arrest and sudden death. Prolonged QTc interval due to increased DDD has not yet been investigated.
Objective
To investigate whether increased DDD of antipsychotics, causes further prolonged QTc, by patients diagnosed with schizophrenia.
Aims
To learn more about antipsychotics impact on the QTc interval in patients diagnosed with schizophrenia.
Methods
An observational study of unselected patients diagnosed with schizophrenia. Enrolled from January 2013 through March 2015 with follow-up until June 2015 in the region of central Denmark. Data was collected from ECG records and patient journals.
Result
ECGs were available in 58 patients. We observed no relation between increased DDD of antipsychotics and prolonged QTc. There were no differences in average QTc interval for the whole sample of patients receiving different DDD of antipsychotics.
Conclusion
We do not recommend increased attention to patients treated with higher DDD of antipsychotics.
Disclosure of interest
The authors have not supplied their declaration of competing interest.
- Type
- e-Poster Viewing: Schizophrenia and other psychotic disorders
- Information
- European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. s805
- Copyright
- Copyright © European Psychiatric Association 2017
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