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Reasons for relapses in patients with schizophrenia admitted to acute units

Published online by Cambridge University Press:  16 April 2020

L. San-Molina ,
G. Rubio ,
I. Bernardo-Fernández  and
S. Miguélez-Fernández
L. San-Molina
Affiliation:
Department of Child and Adolescent Psychiatry, Hospital San Joan de Déu, Barcelona, Spain
G. Rubio
Affiliation:
Department of Psychiatry, Hospital Universitario 12 de Octubre, Spain
I. Bernardo-Fernández
Affiliation:
Medical Department, Janssen-Cilag, Madrid, Spain
S. Miguélez-Fernández
Affiliation:
Medical Department, Janssen-Cilag, Madrid, Spain

Abstract

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Introduction

Relapses are common and a higher number of relapses involve a greater cognitive impairment of the patient. Prevention of relapses is therefore the primary objective of treatment.

Objectives

To establish why a sample of patients with schizophrenia experience relapses and are admitted to acute units as a result.

Methods

A multicenter, naturalistic, retrospective study assessing medical intervention in 1346 patients with schizophrenia admitted to acute units in Spain, assessing the following causes of relapses: non-compliance, lack of efficacy, drug abuse, stress and high incidence of side effects.

Results

90.8% of patients were admitted for relapse. Reasons for admission were non-compliance in 67.1% (77.2% due to lack of insight and 30.59% due to drug abuse), lack of therapeutic efficacy in 27.2%, and drug abuse in 24.3%. In addition, stress and a high incidence of side effects in 5.8% of patients were other reasons for relapse.

Conclusions

Non compliance is the main reason for relapses followed by lack of efficacy. The results appear to confirm that drug abuse might influence in a direct (drug abuse itself) or indirect (non compliance because of drug abuse) way in a higher number of relapses.

Type
P03-180
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 1349
Copyright
Copyright © European Psychiatric Association 2011
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