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Remitted but still impaired? Symptomatic versus functional remission in patients with schizophrenia

Published online by Cambridge University Press:  15 April 2020

A. Karow ,
S. Moritz ,
M. Lambert ,
D. Schöttle ,
D. Naber  and
on behalf of the EGOFORS initiative
A. Karow*
Affiliation:
Psychosis Early Detection and Intervention Centre (PEDIC), Department of Psychiatry and Psychotherapy, Centre for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246Hamburg, Germany
S. Moritz
Affiliation:
Psychosis Early Detection and Intervention Centre (PEDIC), Department of Psychiatry and Psychotherapy, Centre for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246Hamburg, Germany
M. Lambert
Affiliation:
Psychosis Early Detection and Intervention Centre (PEDIC), Department of Psychiatry and Psychotherapy, Centre for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246Hamburg, Germany
D. Schöttle
Affiliation:
Psychosis Early Detection and Intervention Centre (PEDIC), Department of Psychiatry and Psychotherapy, Centre for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246Hamburg, Germany
D. Naber
Affiliation:
Psychosis Early Detection and Intervention Centre (PEDIC), Department of Psychiatry and Psychotherapy, Centre for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246Hamburg, Germany
*
*Corresponding author. Tel.: +49 40 7410 57384; fax: +49 40 7410 55455. E-mail address: karow@uke.de (A. Karow).
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Abstract

Introduction

Studies reported close associations between functional outcome and symptomatic remission as defined by the Remission in Schizophrenia Working Group. This observational study was aimed at the investigation of deficits in daily functioning, symptoms and subjective well-being in remitted and non-remitted patients with schizophrenia.

Methods

Symptoms (PANSS), functional outcome (FROGS, GAF), subjective well-being (SWN-K) and other characteristics were assessed in 131 patients with schizophrenia (DSM-IV) within the European Group on Functional Outcomes and Remission in Schizophrenia (EGOFORS) project.

Results

A significant better level of functioning was measured for remitted versus non-remitted patients, though remitted patients still showed areas with an inadequate level of functioning. Functional deficits were most often seen in social relations (40%), work (29%) and daily life activities (17%). Best functioning was assessed for self-care, self-control, health management and medical treatment. A moderate to severe level of disorganization and emotional distress was observed in 38% and impaired subjective well-being in 29% of patients defined as being in symptomatic remission.

Discussion

The results confirm a close association between symptomatic remission and functional outcome. However, deficits in different areas of functioning, symptoms and well-being underline the need for combined outcome criteria for patients with schizophrenia.

Keywords

SchizophreniaRemissionRecoveryFunctional outcomeSubjective well-being
Type
Original articles
Information
European Psychiatry , Volume 27 , Issue 6 , August 2012 , pp. 401 - 405
Copyright
Copyright © Elsevier Masson SAS 2012

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Footnotes

1

Denotes equal contribution.

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