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The role of inflammation in pathogenesis of juvenile schizophrenia

Published online by Cambridge University Press:  13 August 2021

S. Zozulya ,
M. Omelchenko ,
I. Otman ,
A. Yakimets ,
Z. Sarmanova ,
V. Kaleda  and
T. Klyushnik
S. Zozulya*
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
M. Omelchenko
Affiliation:
Department Of Youth Psychiatry, Mental Health Research Centre, Moscow, Russian Federation
I. Otman
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
A. Yakimets
Affiliation:
Department Of Youth Psychiatry, Mental Health Research Centre, Moscow, Russian Federation
Z. Sarmanova
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
V. Kaleda
Affiliation:
Department Of Youth Psychiatry, Mental Health Research Centre, Moscow, Russian Federation
T. Klyushnik
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Inflammation is now known to be a key factor in the development of schizophrenia. In this regard, the study of the pathogenic role of inflammation in the early stages of schizophrenic process is of particular importance, making it possible to assess its activity and to predict the development of the disease.

Objectives

To compare the dynamics of inflammatory markers in blood of first-episode psychosis (FEP) patients and people at risk signs for schizophrenia in the course of the treatment. Juvenile depression (JD) with attenuated symptoms of schizophrenic spectrum (ASSS) was investigated as a risk group.

Methods

The patients aged 17-25 years (20 people, of which 10 FEP patients (F20) and 10 JD with ASSS ones (F32.1-2, F32.38, F32.8)) were examined at admission to the hospital and at discharge. The controls consisted of 10 healthy volunteers. Symptom severity was collected using PANSS, SOPS, SANS, HDRS. The inflammation markers (TNF-α, IL-6, IL-10, leukocyte elastase (LE), CRP, α1-proteinase inhibitor (α1-PI), anti-S100-beta antibodies) were determined in blood.

Results

An increase of inflammatory markers in both groups compared to controls was found (p<0,05). The highest values of IL-6, LE, CRP, α1-PI and anti-S100-beta antibodies in FEP patients were revealed (p=0,03). After the treatment, the positive trend of inflammatory markers in FEP patients (p<0,05), but not in JD with ASSS patients was detected (except LE activity, p<0,05).

Conclusions

The results confirm the pathogenic role of inflammation in the development of endogenous mental disorders. The inflammatory markers studied reflect the activity of the pathological process in the early stages of schizophrenia.

Disclosure

No significant relationships.

Keywords

attenuated symptoms of schizophrenic spectrumfirst-episode psychosisinflammatory markersjuvenile depression
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S764 - S765
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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