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Sensitivity and specificity of the Italian version of the bipolar spectrum diagnostic scale. Different scores in distinct populations with unipolar depression

Published online by Cambridge University Press:  23 March 2020

D. Piacentino ,
P. Girardi ,
K.G.D. Md ,
L. Sanna ,
I. Pacchiarotti ,
D.P. Rossi ,
N. Girardi ,
S. Rizzato ,
G. Callovini  and
G. Sani
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D. Piacentino
Affiliation:
NESMOS department (neurosciences, mental health, and sensory organs), Sapienza university of Rome, school of medicine and psychology, Sant’Andrea hospital, Rome, Italy Psychiatric division, San Maurizio hospital, sanitary agency of South Tyrol, Bolzano, Italy
P. Girardi
Affiliation:
Bipolar disorders programme, institute of clinical neuroscience, hospital Clinic, university of Barcelona, Idibaps, Cibersam, Barcelona, España
K.G.D. Md
Affiliation:
Bipolar disorders programme, institute of clinical neuroscience, hospital Clinic, university of Barcelona, Idibaps, Cibersam, Barcelona, España Neurobehavioral clinical research section, social and behavioral research branch, National human genome research institute (NHGRI), National institutes of health (NIH)BethesdaMaryland20892USA
L. Sanna
Affiliation:
Psychiatric division, San Maurizio hospital, sanitary agency of South Tyrol, Bolzano, Italy
I. Pacchiarotti
Affiliation:
Bipolar disorders programme, institute of clinical neuroscience, hospital Clinic, university of Barcelona, Idibaps, Cibersam, Barcelona, España
D.P. Rossi
Affiliation:
NESMOS department (neurosciences, mental health, and sensory organs), Sapienza university of Rome, school of medicine and psychology, Sant’Andrea hospital, Rome, Italy Neurobehavioral clinical research section, social and behavioral research branch, National human genome research institute (NHGRI), National institutes of health (NIH)BethesdaMaryland20892USA
N. Girardi
Affiliation:
Department of neurology and psychiatry, Sapienza–university of Roma, policlinico umberto I, Rome, Italy
S. Rizzato
Affiliation:
NESMOS department (neurosciences, mental health, and sensory organs), Sapienza university of Rome, school of medicine and psychology, Sant’Andrea hospital, Rome, Italy
G. Callovini
Affiliation:
NESMOS department (neurosciences, mental health, and sensory organs), Sapienza university of Rome, school of medicine and psychology, Sant’Andrea hospital, Rome, Italy
G. Sani
Affiliation:
NESMOS department (neurosciences, mental health, and sensory organs), Sapienza university of Rome, school of medicine and psychology, Sant’Andrea hospital, Rome, Italy
G. Manfredi
Affiliation:
NESMOS department (neurosciences, mental health, and sensory organs), Sapienza university of Rome, school of medicine and psychology, Sant’Andrea hospital, Rome, Italy
R. Brugnoli
Affiliation:
NESMOS department (neurosciences, mental health, and sensory organs), Sapienza university of Rome, school of medicine and psychology, Sant’Andrea hospital, Rome, Italy
M. Pompili
Affiliation:
NESMOS department (neurosciences, mental health, and sensory organs), Sapienza university of Rome, school of medicine and psychology, Sant’Andrea hospital, Rome, Italy
R. Pies
Affiliation:
Department of psychiatry, SUNY upstate medical university, SyracuseNYUSA
S.N. Ghaemi
Affiliation:
Mood disorder program and psychopharmacology consultation clinic, Tufts medical center, Tufts university school of medicine, BostonMAUSA
L. Mazzarini
Affiliation:
NESMOS department (neurosciences, mental health, and sensory organs), Sapienza university of Rome, school of medicine and psychology, Sant’Andrea hospital, Rome, Italy

Abstract

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Introduction

To date, the proposition of recurrence as a subclinical bipolar disorder feature has not received adequate testing.

Objectives/Aims

We used the Italian version of the bipolar spectrum diagnostic scale (BSDS), a self-rated questionnaire of bipolar risk, in a sample of patients with mood disorders to test its specificity and sensitivity in identifying cases and discriminating between high risk for bipolar disorder major depressive patients (HRU) and low risk (LRU) adopting as a high recurrence cut-off five or more lifetime major depressive episodes.

Methods

We included 115 patients with DSM-5 bipolar disorder (69 type I, 41 type II, and 5 NOS) and 58 with major depressive disorder (29 HRU and 29 LRU, based on the recurrence criterion). Patients filled-out the Italian version of the BSDS, which is currently undergoing a validation process.

Results

The BSDS, adopting a threshold of 14, had 84% sensitivity and 76% specificity. HRU, as predicted, scored on the BSDS intermediate between LRU and bipolar disorder. Clinical characteristics of HRU were more similar to bipolar disorder than to LRU; HRU, like bipolar disorder patients, had more lifetime hospitalizations, higher suicidal ideation and attempt numbers, and higher rates of family history of suicide.

Conclusions

The BSDS showed satisfactory sensitivity and sensitivity. Splitting the unipolar sample into HRU and LRU, on the basis of the at least 5 lifetime major depressive episodes criterion, yielded distinct unipolar subpopulations that differ on outcome measures and BSDS scores.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Walk: Ethics and psychiatry/Philosophy and psychiatry/Others–Part 1
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S333
Copyright
Copyright © European Psychiatric Association 2017
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