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Traumatic brain injury alters presentation of mild behavioral impairment domains across progression of all-cause dementia

Published online by Cambridge University Press:  01 September 2022

M. Bray ,
B. Bryant ,
A. Esagoff ,
L. Richey ,
C. Rodriguez ,
A. Krieg ,
C.M. Cullum ,
C. Lobue ,
Z. Ismail  and
M. Peters
M. Bray*
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
B. Bryant
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
A. Esagoff
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
L. Richey
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
C. Rodriguez
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
A. Krieg
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
C.M. Cullum
Affiliation:
University of Texas Southwestern, Department Of Psychiatry, Dallas, United States of America
C. Lobue
Affiliation:
University of Texas Southwestern, Department Of Psychiatry, Dallas, United States of America
Z. Ismail
Affiliation:
University of Calgary, Department Of Psychiatry, Calgary, Canada
M. Peters
Affiliation:
Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America
*
*Corresponding author.

Abstract

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Introduction

Traumatic brain injury (TBI) may alter dementia progression, although co-occurring neuropsychiatric symptoms (NPS) have received less attention. The mild behavioral impairment (MBI) construct relates NPS to underlying neural circuit disruptions, representing an important area of inquiry regarding TBI and dementia.

Objectives

(1) to examine the influence of prior TBI history (preceding study enrollment) on MBI incidence in all-cause dementia (prior to dementia diagnosis, i.e. MBI’s original definition) and (2) to utilize MBI domains as a construct for examining the influence of TBI on related NPS across the course of dementia onset and progression.

Methods

Using National Alzheimer’s Coordinating Center data, individuals progressing from normal cognition to all-cause dementia over 7.6±3.0 years were studied to estimate MBI incidence and symptom domains in 124 participants with prior TBI history compared to 822 without.

Results

Moderate-severe TBI was associated with the social inappropriateness MBI domain (ORadj.=4.034; p=0.024) prior to dementia onset, and the abnormal perception/thought content domain looking across dementia progression (HRadj.=3.703, p=0.005). TBI (all severities) was associated with the decreased motivation domain looking throughout dementia progression (HRadj.=1.546,p=0.014).

Conclusions

TBI history is associated with particular MBI domains prior to onset and throughout progression of dementia. Understanding TBI’s impact on inter-related NPS may help elucidate underlying neuropathology.

Disclosure

No significant relationships.

Keywords

Dementianeurodegenerationtraumatic brain injurymild behavioral impairment
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S172 - S173
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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