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Use of the Hypomania Checklist-32 and the Mood Disorder Questionnaire for detecting bipolarity in 1,051 patients with major depressive disorder

Published online by Cambridge University Press:  11 February 2011

J.K. Rybakowski ,
D. Dudek ,
T. Pawlowski ,
D. Lojko ,
M. Siwek  and
A. Kiejna
J.K. Rybakowski*
Affiliation:
Department of Adult Psychiatry, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572, Poznan, Poland
D. Dudek
Affiliation:
Department of Psychiatry, Jagiellonian University, ul. Kopernika 21A, 31-501Krakow, Poland
T. Pawlowski
Affiliation:
Department of Psychiatry, Medical University of Wroclaw, Wroclaw, Poland
D. Lojko
Affiliation:
Department of Adult Psychiatry, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572, Poznan, Poland
M. Siwek
Affiliation:
Department of Psychiatry, Jagiellonian University, ul. Kopernika 21A, 31-501Krakow, Poland
A. Kiejna
Affiliation:
Department of Psychiatry, Medical University of Wroclaw, Wroclaw, Poland
*
*Corresponding author. Tel.: +48 61 8475 087; fax: +48 61 8480 392. E-mail address:rybakows@wlkp.top.pl (J.K. Rybakowski).
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Abstract

Purpose

To use the Hypomania Checklist (HCL-32) and the Mood Disorder Questionnaire (MDQ), for detecting bipolarity in depressed patients.

Patients

One thousand and fifty-one patients fulfilling ICD-10 criteria for unipolar major depressive episode, single or recurrent, were studied. Patients were assessed using a structured demographic and clinical data interview, and by the Polish versions of the HCL-32 and MDQ questionnaires.

Results

Hypomanic symptoms exceeding cut-off criteria for bipolarity by HCL-32 were found in 37.5% of patients and, by MDQ, in 20% of patients. Patients with HCL-32 (+) or MDQ (+) differed significantly from patients with HCl-32 (−) and MDQ (−) respectively, by being less frequently married, having more family history of depression, bipolar disorder, alcoholism and suicide, earlier onset of illness, and more depressive episodes and psychiatric hospitalizations. The percentage of patients resistant to treatment with antidepressant drugs was significantly higher in HCL-32 (+) vs HCL-32 (−) and in MDQ (+) vs MDQ (−): 43.9% vs 30.0%, and 26.4% vs 12.4%, respectively.

Conclusions

The results confirm a substantial percentage of bipolarity in major depressive disorder. Such patients have a number of clinical characteristics pointing on a more severe form of the illness and their depression is more resistant to treatment with antidepressants.

Keywords

HypomaniaMood Disorder QuestionnaireHypomania Checklist -32Major depressive disorderBipolarity
Type
Original articles
Information
European Psychiatry , Volume 27 , Issue 8 , November 2012 , pp. 577 - 581
Copyright
Copyright © European Psychiatric Association 2012

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Footnotes

1

Tel.: +48 12 4248703; fax: +48 12 4248745.

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