Forty-one factorial experiments on rates and forms of the three major elements and rates of some minor and trace elements were carried out over the period 1954–1962 in Iringa, as part of a project to introduce Virginian-type tobacco varieties into the area. There were major responses to nitrogen and phosphate, and a close relationship between their effects, but no responses to other elements. Nitrogen raised yield, particularly in wet seasons, but generally tended to reduce quality, severely above 44 lb N per acre and at lower levels in dry years. Phosphate raised yield and quality, and in some instances crop failures occurred in its absence. Data suggested the optimal N : P2O5 ratio in fertilizer mixtures to be 1 : 15. Despite lack of response to potassium a small amount was recommended, to cover requirements for leaf characteristics which were not measured. The programme amply succeeded in its aim of establishing ‘average’ fertilizer recommendations, which were fundamentally sound, for the whole of the Iringa tobacco growing area. These recommendations are summarized.