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Adrenomedullin and proadrenomudullin N-terminal 20 peptide (PAMP) are present in human colonic epithelia and exert an antimicrobial effect

Published online by Cambridge University Press:  24 September 2001

K. Marutsuka ,
Y. Nawa ,
Y. Asada ,
S. Hara ,
K. Kitamura ,
T. Eto  and
A. Sumiyoshi
K. Marutsuka
Affiliation:
First Department of Pathology, Department of Parasitology and First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
Y. Nawa
Affiliation:
First Department of Pathology, Department of Parasitology and First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
Y. Asada
Affiliation:
First Department of Pathology, Department of Parasitology and First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
S. Hara
Affiliation:
First Department of Pathology, Department of Parasitology and First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
K. Kitamura
Affiliation:
First Department of Pathology, Department of Parasitology and First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
T. Eto
Affiliation:
First Department of Pathology, Department of Parasitology and First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
A. Sumiyoshi
Affiliation:
First Department of Pathology, Department of Parasitology and First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
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Abstract

The hypotensive and vasorelaxing peptides adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), were found to be distributed on the surface of the colonic mucosa. AM and PAMP showed dose-dependent antimicrobial activity against E. coli. The results suggest that the novel vasoactive peptides AM and PAMP play an important role in mucosal defence. Experimental Physiology (2001) 86.5, 543-545.

Type
Rapid Communications
Information
Experimental Physiology , Volume 86 , Issue 5 , September 2001 , pp. 543 - 545
Copyright
© The Physiological Society 2001

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