Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging

James A. Deane; Michael J. Hickey

doi:10.1017/S146239940900115X

Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging

Published online by Cambridge University Press: 20 August 2009

James A. Deane and

Michael J. Hickey

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James A. Deane: Affiliation:
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Australia.
Michael J. Hickey*: Affiliation:
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Australia.
*: *Corresponding author: Michael Hickey, Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 246 Clayton Rd., Clayton, 3168, Australia, Tel: +61 3 9594 5519; Fax: +61 3 9594 6495; E-mail: michael.hickey@med.monash.edu.au

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Abstract

Infiltration of T cells is a key step in the pathogenesis of the inflammatory skin diseases atopic dermatitis, allergic contact dermatitis and psoriasis. Understanding the mechanisms of T cell recruitment to the skin is therefore of fundamental importance for the discovery and application of novel therapies for these conditions. Studies of both clinical samples and experimental models of skin inflammation have implicated specific adhesion molecules and chemokines in lymphocyte recruitment. In particular, recent studies using advanced in vivo imaging techniques have greatly increased our understanding of the kinetics and molecular basis of this process. In this review, we summarise the current understanding of the cellular immunology of antigen-driven dermal inflammation and the roles of adhesion molecules and chemokines. We focus on results obtained using intravital microscopy to examine the dermal microvasculature and interstitium to determine the mechanisms of T cell recruitment and migration in experimental models of T-cell-mediated skin inflammation.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 11 , July 2009 , e25

DOI: https://doi.org/10.1017/S146239940900115X [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2009

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Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging

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Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging

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