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Toll-like receptors and intestinal defence: molecular basis and therapeutic implications

Published online by Cambridge University Press:  13 February 2004

Elke Cario
Elke Cario
Affiliation:
Division of Gastroenterology and Hepatology, University of Essen, Institutsgruppe I /C/8, Virchowstr. 171, D-45147 Essen, Germany.
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Abstract

Toll-like receptors (TLRs) play a principle role in distinct pathogen recognition and in the initiation of innate immune responses of the intestinal mucosa. Activated innate immunity interconnects downstream with adaptive immunity in complex feedback regulatory loops. Intestinal disease might result from inappropriate activation of the mucosal immune system driven by TLRs in response to normal luminal flora.

Keywords

host defenceinnate immunitymucosainflammatory bowel diseaseToll-like receptorTLRintestinal epithelial celltolerancemicrofloracytokine
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 5 , Issue 19 , 7 July 2003 , pp. 1 - 15
Copyright
© Cambridge University Press 2003

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