Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-17T13:42:40.018Z Has data issue: false hasContentIssue false
  • English
  • Français

MicroRNAs regulating SOX2 in cancer progression and therapy response

Published online by Cambridge University Press:  29 September 2021

Sepideh Mirzaei ,
Hamidreza Saebfar ,
Mohammad Hossein Gholami ,
Farid Hashemi ,
Ali Zarrabi ,
Amirhossein Zabolian ,
Maliheh Entezari ,
Kiavash Hushmandi ,
Saeed Samarghandian  and
Amir Reza Aref
...Show all authors
Sepideh Mirzaei
Affiliation:
Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran
Hamidreza Saebfar
Affiliation:
Asu Vanda Gene Industrial Research Company, Tehran, Iran
Mohammad Hossein Gholami
Affiliation:
Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
Farid Hashemi
Affiliation:
Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Ali Zarrabi
Affiliation:
Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla34956, Istanbul, Turkey
Amirhossein Zabolian
Affiliation:
Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Maliheh Entezari
Affiliation:
Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Kiavash Hushmandi
Affiliation:
Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Saeed Samarghandian
Affiliation:
Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
Amir Reza Aref*
Affiliation:
Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA Department of Translational Sciences, Xsphera Biosciences Inc., Boston, MA, USA
Milad Ashrafizadeh
Affiliation:
Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla34956Istanbul, Turkey
Haroon Khan*
Affiliation:
Department of Pharmacy, Abdul Wali Khan University, Mardan23200, Pakistan
*
Author for correspondence: Amir Reza Aref, Haroon Khan, E-mail: Amir_aref@hms.harvard.edu, haroonkhan@awkum.edu.pk
Author for correspondence: Amir Reza Aref, Haroon Khan, E-mail: Amir_aref@hms.harvard.edu, haroonkhan@awkum.edu.pk
Get access Rights & Permissions [Opens in a new window]

Abstract

The proliferation, metastasis and therapy response of tumour cells are tightly regulated by interaction among various signalling networks. The microRNAs (miRNAs) can bind to 3′-UTR of mRNA and down-regulate expression of target gene. The miRNAs target various molecular pathways in regulating biological events such as apoptosis, differentiation, angiogenesis and migration. The aberrant expression of miRNAs occurs in cancers and they have both tumour-suppressor and tumour-promoting functions. On the contrary, SOX proteins are capable of binding to DNA and regulating gene expression. SOX2 is a well-known member of SOX family that its overexpression in different cancers to ensure progression and stemness. The present review focuses on modulatory impact of miRNAs on SOX2 in affecting growth, migration and therapy response of cancers. The lncRNAs and circRNAs can function as upstream mediators of miRNA/SOX2 axis in cancers. In addition, NF-κB, TNF-α and SOX17 are among other molecular pathways regulating miRNA/SOX2 axis in cancer. Noteworthy, anti-cancer compounds including bufalin and ovatodiolide are suggested to regulate miRNA/SOX2 axis in cancers. The translation of current findings to clinical course can pave the way to effective treatment of cancer patients and improve their prognosis.

Keywords

Anti-tumour compoundbiological functioncancerchemotherapyLncRNAmicroRNAnon-coding RNASOXtranscription factor
Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 23 , 2021 , e13
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Zhang, Q et al. (2020) Roles and regulatory mechanisms of miR-30b in cancer, cardiovascular disease, and metabolic disorders. Experimental and Therapeutic Medicine 21, 1–1.CrossRefGoogle ScholarPubMed
Pan, Y-J, Wan, J and Wang, C-B (2019) MiR-326: promising biomarker for cancer. Cancer Management and Research 11, 10411.CrossRefGoogle ScholarPubMed
Kubatka, P et al. (2021) Rhus coriaria L.(Sumac) demonstrates oncostatic activity in the therapeutic and preventive model of breast carcinoma. International Journal of Molecular Sciences 22, 183.CrossRefGoogle Scholar
Varghese, E et al. (2020) Anti-angiogenic effects of phytochemicals on miRNA regulating breast cancer progression. Biomolecules 10, 191.CrossRefGoogle ScholarPubMed
Bautista-Sánchez, D et al. (2020) The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics. Molecular Therapy. Nucleic Acids 20, 409–420.CrossRefGoogle ScholarPubMed
Cao, Z et al. (2020) MiR-135a biogenesis and regulation in malignancy: a new hope for cancer research and therapy. Cancer Biology & Medicine 17, 569–582.CrossRefGoogle ScholarPubMed
Wang, JY et al. (2020) Potential regulatory role of lncRNA-miRNA-mRNA axis in osteosarcoma. Biomedicine & Pharmacotherapy 121, 109627.CrossRefGoogle ScholarPubMed
Liang, ZZ et al. (2020) circRNA-miRNA-mRNA regulatory network in human lung cancer: an update. Cancer Cell International 20, 173.CrossRefGoogle ScholarPubMed
Greenhill, C (2017) Adipose tissue: exosomal microRNAs – novel adipokines. Nature Reviews. Endocrinology 13, 188.CrossRefGoogle ScholarPubMed
Guay, C and Regazzi, R (2013) Circulating microRNAs as novel biomarkers for diabetes mellitus. Nature Reviews. Endocrinology 9, 513–521.CrossRefGoogle ScholarPubMed
Lian, JB et al. (2012) MicroRNA control of bone formation and homeostasis. Nature Reviews. Endocrinology 8, 212–227.CrossRefGoogle ScholarPubMed
Ray, J et al. (2020) miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA. Cancer Letters 473, 107–117.CrossRefGoogle ScholarPubMed
Wang, H et al. (2020) miR-101-3p and miR-199b-5p promote cell apoptosis in oral cancer by targeting BICC1. Molecular and Cellular Probes 52, 101567.CrossRefGoogle ScholarPubMed
Bartel, DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281–297.CrossRefGoogle ScholarPubMed
Ambros, V (2004) The functions of animal microRNAs. Nature 431, 350–355.CrossRefGoogle ScholarPubMed
O'Brien, J et al. (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Frontiers in Endocrinology 9, 402.CrossRefGoogle ScholarPubMed
Cai, Y et al. (2009) A brief review on the mechanisms of miRNA regulation. Genomics, Proteomics & Bioinformatics 7, 147–154.CrossRefGoogle ScholarPubMed
Lu, S et al. (2020) MiR-483 targeted SOX3 to suppress glioma cell migration, invasion and promote cell apoptosis. OncoTargets and Therapy 13, 2153–2161.CrossRefGoogle ScholarPubMed
Zhao, G, Yin, Y and Zhao, B (2020) miR-140-5p is negatively correlated with proliferation, invasion, and tumorigenesis in malignant melanoma by targeting SOX4 via the Wnt/β-catenin and NF-κB cascades. Journal of Cellular Physiology 235, 2161–2170.CrossRefGoogle ScholarPubMed
Zhao, J et al. (2019) Long non-coding RNA HCP5 facilitates cell invasion and epithelial-mesenchymal transition in oral squamous cell carcinoma by miR-140-5p/SOX4 axis. Cancer Management and Research 11, 10455–10462.CrossRefGoogle ScholarPubMed
Yang, Z et al. (2020) miR-23a-3p regulated by LncRNA SNHG5 suppresses the chondrogenic differentiation of human adipose-derived stem cells via targeting SOX6/SOX5. Cell and Tissue Research 383, 723–733.CrossRefGoogle ScholarPubMed
Grimm, D et al. (2019) The role of SOX family members in solid tumours and metastasis. Seminars in Cancer Biology 67, 122–153.CrossRefGoogle ScholarPubMed
Kumar, P and7Mistri, TK (2019) Transcription factors in SOX family: potent regulators for cancer initiation and development in the human body. Seminars in Cancer Biology 6, 105–113.Google Scholar
Olbromski, M, Podhorska-Okołów, M and Dzięgiel, P (2020) Role of SOX protein groups F and H in lung cancer progression. Cancers 12, 3235.CrossRefGoogle Scholar
Williams, CA, Soufi, A and Pollard, SM (2019) Post-translational modification of SOX family proteins: key biochemical targets in cancer? Seminars in Cancer Biology 67, 30–38.CrossRefGoogle ScholarPubMed
Ashrafizadeh, M et al. (2021) Interplay between SOX9 transcription factor and microRNAs in cancer. International Journal of Biological Macromolecules 183, 681–694.CrossRefGoogle ScholarPubMed
Abadi, AJ et al. (2021) The role of SOX family transcription factors in gastric cancer. International Journal of Biological Macromolecules 180, 608–624.CrossRefGoogle ScholarPubMed
Bowles, J, Schepers, G and Koopman, P (2000) Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Developmental Biology 227, 239–255.CrossRefGoogle ScholarPubMed
Koopman, P et al. (1991) Male development of chromosomally female mice transgenic for Sry. Nature 351, 117–121.CrossRefGoogle ScholarPubMed
Südbeck, P and Scherer, G (1997) Two independent nuclear localization signals are present in the DNA-binding high-mobility group domains of SRY and SOX9. Journal of Biological Chemistry 272, 27848–27852.CrossRefGoogle ScholarPubMed
Gasca, S et al. (2002) A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination. Proceedings of the National Academy of Sciences 99, 11199–11204.CrossRefGoogle ScholarPubMed
Ashrafizadeh, M et al. (2020) Cancer and SOX proteins: new insight into their role in ovarian cancer progression/inhibition. Pharmacological Research 161, 105159.CrossRefGoogle ScholarPubMed
Schepers, GE, Teasdale, RD and Koopman, P (2002) Twenty pairs of SOX: extent, homology, and nomenclature of the mouse and human SOX transcription factor gene families. Developmental Cell 3, 167–170.CrossRefGoogle ScholarPubMed
Guth, S and Wegner, M (2008) Having it both ways: Sox protein function between conservation and innovation. Cellular and Molecular Life Sciences 65, 3000–3018.CrossRefGoogle ScholarPubMed
King, N et al. (2008) The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature 451, 783–788.CrossRefGoogle ScholarPubMed
Lin, YW et al. (2013) SOX1 Suppresses cell growth and invasion in cervical cancer. Gynecologic Oncology 131, 174–181.CrossRefGoogle ScholarPubMed
Tang, L et al. (2019) Aberrant DNA methylation of PAX1, SOX1 and ZNF582 genes as potential biomarkers for esophageal squamous cell carcinoma. Biomedicine & Pharmacotherapy 120, 109488.CrossRefGoogle ScholarPubMed
Li, N and Li, S (2015) Epigenetic inactivation of SOX1 promotes cell migration in lung cancer. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine 36, 4603–4610.CrossRefGoogle ScholarPubMed
Mu, P et al. (2017) SOX2 Promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer. Science 355, 84–88.CrossRefGoogle ScholarPubMed
Schaefer, T and Lengerke, C (2020) SOX2 protein biochemistry in stemness, reprogramming, and cancer: the PI3K/AKT/SOX2 axis and beyond. Oncogene 39, 278–292.CrossRefGoogle ScholarPubMed
Yu, JM et al. (2019) TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription. Nature Communications 10, 5720.CrossRefGoogle ScholarPubMed
Boumahdi, S et al. (2014) SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. Nature 511, 246–250.CrossRefGoogle ScholarPubMed
Wuebben, EL and Rizzino, A (2017) The dark side of SOX2: cancer − a comprehensive overview. Oncotarget 8, 44917.CrossRefGoogle ScholarPubMed
Mirzaei, S et al. (2021) Regulation of nuclear factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: inhibiting or promoting carcinogenesis?. Cancer Letters 509, 63–80.CrossRefGoogle ScholarPubMed
Mirzaei, S et al. (2021) The role of microRNA-338–3p in cancer: growth, invasion, chemoresistance, and mediators. Life sciences 268, 119005. doi: 10.1016/j.lfs.2020.119005.CrossRefGoogle ScholarPubMed
Ashrafizadeh, M et al. (2020) MicroRNAs in cancer therapy: their involvement in oxaliplatin sensitivity/resistance of cancer cells with a focus on colorectal cancer. 256, 117973. doi: 10.1016/j.lfs.2020.117973.CrossRefGoogle Scholar
Ashrafizadeh, M et al. (2020) PD-1/PD-L1 axis regulation in cancer therapy: the role of long non-coding RNAs and microRNAs. 256, 117899. doi: Doi, 10.1016/j.lfs.2020.117899.Google Scholar
Abadi, AJ et al. (2021) Small in size, but large in action: microRNAs as potential modulators of PTEN in breast and lung cancers. 11, 304. doi: 10.3390/biom11020304.CrossRefGoogle Scholar
Ashrafizadeh, M et al. (2020) Lung cancer cells and their sensitivity/resistance to cisplatin chemotherapy: role of microRNAs and upstream mediators. Celluar Signalling 78, 109871. doi: 10.1016/j.cellsig.2020.109871.CrossRefGoogle ScholarPubMed
Zhang, HY and Ma, JH (2020) miR-105 promotes the progression and predicts the prognosis for oral squamous cell carcinoma (OSCC). Cancer Management and Research 12, 11491–11499.CrossRefGoogle Scholar
Wu, Y et al. (2020) High expression of miR-135b predicts malignant transformation and poor prognosis of gastric cancer. Life Sciences 257, 118133.CrossRefGoogle ScholarPubMed
Zhang, HM et al. (2020) MKL1/miR-5100/CAAP1 Loop regulates autophagy and apoptosis in gastric cancer cells. Neoplasia (New York, N.Y.) 22, 220–230.CrossRefGoogle ScholarPubMed
Wu, X et al. (2020) Downregulations of miR-449a and miR-145-5p act as prognostic biomarkers for endometrial cancer. Journal of Computational Biology 27, 834–844.CrossRefGoogle ScholarPubMed
Danarto, R et al. (2020) Urine miR-21-5p and miR-200c-3p as potential non-invasive biomarkers in patients with prostate cancer. Turkish Journal of Urology 46, 26–30.CrossRefGoogle ScholarPubMed
Ye, Z et al. (2020) MiR-92b-3p inhibits proliferation and migration of C2C12 cells. Cell Cycle 19, 2906–2917.CrossRefGoogle ScholarPubMed
Yang, M et al. (2019) miR-125 inhibits colorectal cancer proliferation and invasion by targeting TAZ. Bioscience Reports 39, BSR20190193.Google ScholarPubMed
Shayimu, P et al. (2020) miR-922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer. Kaohsiung Journal of Medical Sciences 36, 178–185.CrossRefGoogle ScholarPubMed
Wang, B et al. (2020) Exosomal miR-1910-3p promotes proliferation, metastasis, and autophagy of breast cancer cells by targeting MTMR3 and activating the NF-κB signaling pathway. Cancer Letters 489, 87–99.CrossRefGoogle ScholarPubMed
Liu, H et al. (2020) MiR-194-5p inhibited metastasis and EMT of nephroblastoma cells through targeting Crk. Kaohsiung Journal of Medical Sciences 36, 265–273.CrossRefGoogle ScholarPubMed
Luo, Y et al. (2019) miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells. Journal of Experimental & Clinical Cancer Research: CR 38, 488.CrossRefGoogle ScholarPubMed
Wan, FZ et al. (2020) Exosomes overexpressing miR-34c inhibit malignant behavior and reverse the radioresistance of nasopharyngeal carcinoma. Journal of Translational Medicine 18, 12.CrossRefGoogle ScholarPubMed
Chavez-Dominguez, R et al. (2020) The double-edge sword of autophagy in cancer: from tumor suppression to pro-tumor activity. Frontiers in Oncology 10, 578418.CrossRefGoogle ScholarPubMed
Zhao, S et al. (2020) Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer. Journal of Hematology & Oncology 13, 156.CrossRefGoogle ScholarPubMed
Majid, A et al. (2020) miR-124-3p suppresses the invasiveness and metastasis of hepatocarcinoma cells via targeting CRKL. Frontiers in Molecular Biosciences 7, 223.CrossRefGoogle ScholarPubMed
Zhang, YM et al. (2020) miR-34a and miR-125a-5p inhibit proliferation and metastasis but induce apoptosis in hepatocellular carcinoma cells via repressing the MACC1-mediated PI3K/AKT/mTOR pathway. Neoplasma 67, 1042–1053.CrossRefGoogle ScholarPubMed
Novak, D et al. (2019) SOX2 in development and cancer biology. Seminars in Cancer Biology 67, 74–82.CrossRefGoogle ScholarPubMed
Stevanovic, M et al. (1994) The cDNA sequence and chromosomal location of the human SOX2 gene. Mammalian Genome 5, 640–642.CrossRefGoogle ScholarPubMed
Castillo, SD and Sanchez-Cespedes, M (2012) The SOX family of genes in cancer development: biological relevance and opportunities for therapy. Expert Opinion on Therapeutic Targets 16, 903–919.CrossRefGoogle ScholarPubMed
Weina, K and Utikal, J (2014) SOX2 and cancer: current research and its implications in the clinic. Clinical and Translational Medicine 3, 19.CrossRefGoogle ScholarPubMed
Hüser, L et al. (2018) Targeting SOX2 in anticancer therapy. Expert Opinion on Therapeutic Targets 22, 983–991.CrossRefGoogle ScholarPubMed
Boyer, LA et al. (2005), Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122, 947–956.CrossRefGoogle ScholarPubMed
Wang, J et al. (2006) A protein interaction network for pluripotency of embryonic stem cells. Nature 444, 364–368.CrossRefGoogle ScholarPubMed
Kim, J et al. (2008) An extended transcriptional network for pluripotency of embryonic stem cells. Cell 132, 1049–1061.CrossRefGoogle ScholarPubMed
Hu, PS et al. (2020) VDR-SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment. Signal Transduction and Targeted Therapy 5, 183.CrossRefGoogle Scholar
Hussenet, T et al. (2010) SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas. PLoS ONE 5, e8960.CrossRefGoogle ScholarPubMed
Albertson, DG (2006) Gene amplification in cancer. Trends in Genetics 22, 447–455.CrossRefGoogle ScholarPubMed
Annovazzi, L et al. (2011) SOX2 expression and amplification in gliomas and glioma cell lines. Cancer Genomics & Proteomics 8, 139–147.Google ScholarPubMed
Alonso, MM et al. (2011) Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas. PLoS ONE 6, e26740.CrossRefGoogle ScholarPubMed
Hussenet, T and du Manoir, S (2010) SOX2 in squamous cell carcinoma: amplifying a pleiotropic oncogene along carcinogenesis. Cell Cycle 9, 1480–1486.CrossRefGoogle ScholarPubMed
Zhang, XH et al. (2020) The association of SOX2 with clinical features and prognosis in colorectal cancer: a meta-analysis. Pathology Research and Practice 216, 152769.CrossRefGoogle ScholarPubMed
Du, L et al. (2019) MTA3 Represses cancer stemness by targeting the SOX2OT/SOX2 axis. iScience 22, 353–368.CrossRefGoogle ScholarPubMed
Xiao, W et al. (2020) SOX2 promotes brain metastasis of breast cancer by upregulating the expression of FSCN1 and HBEGF. Molecular Therapy Oncolytics 17, 118–129.CrossRefGoogle ScholarPubMed
Chang, X et al. (2020) LncRNA SOX2OT affects cervical cancer cell growth, migration and invasion by regulating SOX2. Cell Cycle 19, 1391–1403.CrossRefGoogle ScholarPubMed
Chandimali, N et al. (2020) BRM270 suppresses cervical cancer stem cell characteristics and progression by inhibiting SOX2. In vivo 34, 1085–1094.CrossRefGoogle ScholarPubMed
Wu, R et al. (2020) SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA. Journal for Immunotherapy of Cancer 8. doi: 10.1136/jitc-2020-001037.CrossRefGoogle ScholarPubMed
Terasaki, K et al. (2021) SOX2 enhances cell survival and induces resistance to apoptosis under serum starvation conditions through the AKT/GSK-3β signaling pathway in esophageal squamous cell carcinoma. Oncology Letters 21, 269.CrossRefGoogle ScholarPubMed
Si, X et al. (2020) SOX2 upregulates side population cells and enhances their chemoresistant ability by transactivating ABCC1 expression contributing to intrinsic resistance to paclitaxel in melanoma. Molecular Carcinogenesis 59, 257–264.CrossRefGoogle ScholarPubMed
Dai, WL, Yuan, SX and Cao, JP (2020) The deubiquitinase USP34 stabilizes SOX2 and induces cell survival and drug resistance in laryngeal squamous cell carcinoma. Kaohsiung Journal of Medical Sciences 36, 983–989.CrossRefGoogle ScholarPubMed
Bora-Singhal, N et al. (2020) Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2. Scientific Reports 10, 4722.CrossRefGoogle ScholarPubMed
Kuo, MH et al. (2020) Cross-talk between SOX2 and TGFβ signaling regulates EGFR-TKI tolerance and lung cancer dissemination. Cancer Research 80, 4426–4438.CrossRefGoogle ScholarPubMed
Choi, HS et al. (2020) The FDA-approved anti-asthma medicine ciclesonide inhibits lung cancer stem cells through hedgehog signaling-mediated SOX2 regulation. International Journal of Molecular Sciences 21. doi: 10.3390/ijms21031014.Google ScholarPubMed
Cuyàs, E et al. (2020) The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes. Aging 12, 4794–4814.CrossRefGoogle ScholarPubMed
Calderon-Aparicio, A et al. (2020) RCC2 promotes esophageal cancer growth by regulating activity and expression of the Sox2 transcription factor. Molecular Cancer Research 18, 1660–1674.CrossRefGoogle ScholarPubMed
Yang, WT et al. (2020) NF-YA promotes the cell proliferation and tumorigenic properties by transcriptional activation of SOX2 in cervical cancer. Journal of Cellular and Molecular Medicine 24, 12464–12475.CrossRefGoogle ScholarPubMed
Qin, C et al. (2020) Cancer-driven IgG promotes the development of prostate cancer though the SOX2-CIgG pathway. Prostate 80, 1134–1144.CrossRefGoogle ScholarPubMed
Hua, X et al. (2020) The inhibitory effect of compound ChlA-F on human bladder cancer cell invasion can be attributed to its blockage of SOX2 protein. Cell Death & Differentiation 27, 632–645.CrossRefGoogle ScholarPubMed
Chiu, YF et al. (2020) Critical role of SOX2-IGF2 signaling in aggressiveness of bladder cancer. Scientific Reports 10, 8261.CrossRefGoogle ScholarPubMed
Ren, C et al. (2016) Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing's sarcoma through the PI3K/Akt pathway. Journal of Experimental & Clinical Cancer Research: CR 35, 44.CrossRefGoogle ScholarPubMed
Riggi, N et al. (2010) EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells. Genes & Development 24, 916–932.CrossRefGoogle ScholarPubMed
Skoda, J et al. (2016) Cancer stem cell markers in pediatric sarcomas: Sox2 is associated with tumorigenicity in immunodeficient mice. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine 37, 9535–9548.CrossRefGoogle ScholarPubMed
Novak, D et al. (2020) SOX2 in development and cancer biology. Seminars in Cancer Biology, 67, 74–82.CrossRefGoogle ScholarPubMed
Lu, J et al. (2021) Lymphatic metastasis-related TBL1XR1 enhances stemness and metastasis in gastric cancer stem-like cells by activating ERK1/2-SOX2 signaling. Oncogene 40, 922–936.CrossRefGoogle ScholarPubMed
Jiang, YY et al. (2020) TP63, SOX2, and KLF5 establish a core regulatory circuitry that controls epigenetic and transcription patterns in esophageal squamous cell carcinoma cell lines. Gastroenterology 159, 1311–1327.e19.CrossRefGoogle ScholarPubMed
Xu, W et al. (2020) MiR-145 in cancer therapy resistance and sensitivity: a comprehensive review. Cancer Science 111, 3122–3131.CrossRefGoogle ScholarPubMed
Moghbeli, M (2021) Molecular interactions of miR-338 during tumor progression and metastasis. Cellular & Molecular Biology Letters 26, 13.CrossRefGoogle ScholarPubMed
Yang, YL et al. (2021) New insights into the role of miR-29a in hepatocellular carcinoma: implications in mechanisms and theragnostics. Journal of Personalized Medicine 11. doi: 10.3390/jpm11030219.CrossRefGoogle ScholarPubMed
Fu, Q et al. (2019) SOX30, a target gene of miR-653-5p, represses the proliferation and invasion of prostate cancer cells through inhibition of Wnt/β-catenin signaling. Cellular & Molecular Biology Letters 24, 71.CrossRefGoogle ScholarPubMed
Liang, H et al. (2020) A PTAL-miR-101-FN1 axis promotes EMT and invasion-metastasis in serous ovarian cancer. Molecular Therapy Oncolytics 16, 53–62.CrossRefGoogle ScholarPubMed
Huang, H et al. (2020) miR-125a regulates HAS1 and inhibits the proliferation, invasion and metastasis by targeting STAT3 in non-small cell lung cancer cells. Journal of Cellular Biochemistry 121, 3197–3207.CrossRefGoogle ScholarPubMed
Liu, P et al. (2018) SOX2 promotes cell proliferation and metastasis in triple negative breast cancer. Frontiers in Pharmacology 9, 942.CrossRefGoogle ScholarPubMed
Zhou, L et al. (2017) MicroRNA miR-590-5p inhibits breast cancer cell stemness and metastasis by targeting SOX2. European Review for Medical and Pharmacological Sciences 21, 87–94.Google ScholarPubMed
Tang, W et al. (2019) miR-145-5p suppresses breast cancer progression by inhibiting SOX2. Journal of Surgical Research 236, 278–287.CrossRefGoogle ScholarPubMed
Bigdelou, Z et al. (2020) Role of Oct4-Sox2 complex decoy oligodeoxynucleotides strategy on reverse epithelial to mesenchymal transition (EMT) induction in HT29-ShE encompassing enriched cancer stem-like cells. Molecular Biology Reports 47, 1859–1869.CrossRefGoogle ScholarPubMed
Chang, Z (2019) Downregulation of SOX2 may be targeted by miR-590-5p and inhibits epithelial-to-mesenchymal transition in non-small-cell lung cancer. Experimental and Therapeutic Medicine 18, 1189–1195.Google ScholarPubMed
Lee, WS et al. (2014) Specificity protein 1 expression contributes to Bcl-w-induced aggressiveness in glioblastoma multiforme. Molecules and Cells 37, 17–23.CrossRefGoogle ScholarPubMed
Lee, WS et al. (2013) Bcl-w enhances mesenchymal changes and invasiveness of glioblastoma cells by inducing nuclear accumulation of β-catenin. PLoS ONE 8, e68030.CrossRefGoogle ScholarPubMed
Kim, S et al. (2019) miR-340-5p suppresses aggressiveness in glioblastoma multiforme by targeting Bcl-w and Sox2. Molecular Therapy. Nucleic Acids 17, 245–255.CrossRefGoogle ScholarPubMed
Wang, Z et al. (2014) miR-625 down-regulation promotes proliferation and invasion in esophageal cancer by targeting Sox2. FEBS Letters 588, 915–921.CrossRefGoogle ScholarPubMed
Ren, Y et al. (2017) MiRNA-638 promotes autophagy and malignant phenotypes of cancer cells via directly suppressing DACT3. Cancer Letters 390, 126–136.CrossRefGoogle ScholarPubMed
Ni, J et al. (2020) Methylation-associated silencing of miR-638 promotes endometrial carcinoma progression by targeting MEF2C. International Journal of Molecular Medicine 45, 1753–1770.Google Scholar
Zhang, H et al. (2020) MicroRNA-638 induces apoptosis and autophagy in human liver cancer cells by targeting enhancer of zeste homolog 2 (EZH2). Environmental Toxicology and Pharmacology 82, 103559.CrossRefGoogle Scholar
Xia, Y et al. (2014) Downregulation of miR-638 promotes invasion and proliferation by regulating SOX2 and induces EMT in NSCLC. FEBS Letters 588, 2238–2245.CrossRefGoogle ScholarPubMed
Hou, P et al. (2020) DKC1 enhances angiogenesis by promoting HIF-1α transcription and facilitates metastasis in colorectal cancer. British Journal of Cancer 122, 668–679.CrossRefGoogle ScholarPubMed
Zhao, C et al. (2016) Enhanced therapeutic effect of an antiangiogenesis peptide on lung cancer in vivo combined with salmonella VNP20009 carrying a Sox2 shRNA construct. Journal of Experimental & Clinical Cancer Research: CR 35, 107.CrossRefGoogle ScholarPubMed
Takahashi, K et al. (2020) Sox2 induces tumorigenesis and angiogenesis of early-stage esophageal squamous cell carcinoma through secretion of Suprabasin. Carcinogenesis 41, 1543–1552.CrossRefGoogle ScholarPubMed
Chen, J et al. (2020) Regulation of cancer stem cell properties, angiogenesis, and vasculogenic mimicry by miR-450a-5p/SOX2 axis in colorectal cancer. Cell Death & Disease 11, 173.CrossRefGoogle ScholarPubMed
Zhong, Z and Virshup, DM (2020) Wnt signaling and drug resistance in cancer. Molecular Pharmacology 97, 72–89.CrossRefGoogle ScholarPubMed
Nguyen, VHL et al. (2019) Wnt/β-catenin signalling in ovarian cancer: insights into its hyperactivation and function in tumorigenesis. Journal of Ovarian Research 12, 122.CrossRefGoogle ScholarPubMed
Guo, Y et al. (2020) Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway. Chemosphere 246, 125775.CrossRefGoogle ScholarPubMed
Liu, S et al. (2020) Dermatopontin inhibits WNT signaling pathway via CXXC finger protein 4 in hepatocellular carcinoma. Journal of Cancer 11, 6288–6298.CrossRefGoogle ScholarPubMed
Song, XL et al. (2018) miR-1301-3p promotes prostate cancer stem cell expansion by targeting SFRP1 and GSK3β. Biomedicine & Pharmacotherapy 99, 369–374.CrossRefGoogle ScholarPubMed
Chhabra, R (2018), let-7i-5p, miR-181a–2-3p and EGF/PI3K/SOX2 axis coordinate to maintain cancer stem cell population in cervical cancer. Scientific Reports 8, 7840.CrossRefGoogle ScholarPubMed
Yu, Y et al. (2015) miR-21 and miR-145 cooperation in regulation of colon cancer stem cells. Molecular Cancer 14, 98.CrossRefGoogle ScholarPubMed
Gopalan, V et al. (2018) Tumour suppressor properties of miR-15a and its regulatory effects on BCL2 and SOX2 proteins in colorectal carcinomas. Experimental Cell Research 370, 245–253.CrossRefGoogle ScholarPubMed
Rahimi, M et al. (2020) Down-regulation of miR-200c and Up-regulation of miR-30c target both stemness and metastasis genes in breast cancer. Cell Journal 21, 467–478.Google ScholarPubMed
Chen, Y et al. (2019) MiR-27b targets PI3K p110α to inhibit proliferation and migration in colorectal cancer stem cell. American Journal of Translational Research 11, 5988–5997.Google ScholarPubMed
Ji, L et al. (2019) MiR-589-5p is downregulated in prostate cancer and regulates tumor cell viability and metastasis by targeting CCL-5. Molecular Medicine Reports 20, 1373–1382.Google Scholar
Long, J et al. (2018) Maintenance of stemness by miR-589-5p in hepatocellular carcinoma cells promotes chemoresistance via STAT3 signaling. Cancer Letters 423, 113–126.CrossRefGoogle ScholarPubMed
Zhang, X et al. (2016) miR-589-5p inhibits MAP3K8 and suppresses CD90(+) cancer stem cells in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research: CR 35, 176.CrossRefGoogle ScholarPubMed
Liu, K et al. (2017) SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e–5p/TUSC3 axis. Molecular Cancer 16, 62.CrossRefGoogle ScholarPubMed
Picon-Ruiz, M et al. (2016) Interactions between adipocytes and breast cancer cells stimulate cytokine production and drive Src/Sox2/miR-302b-mediated malignant progression. Cancer Research 76, 491–504.CrossRefGoogle ScholarPubMed
Forno, I et al. (2015) Deregulation of MiR-34b/Sox2 predicts prostate cancer progression. PLoS ONE 10, e0130060.CrossRefGoogle ScholarPubMed
Mamoori, A et al. (2019) The tumour suppressor effects and regulation of cancer stem cells by macrophage migration inhibitory factor targeted miR-451 in colon cancer. Gene 697, 165–174.CrossRefGoogle Scholar
Jiang, J et al. (2015) MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer. Cancer Letters 356, 962–970.CrossRefGoogle ScholarPubMed
Adamek, A and Kasprzak, A (2018) Insulin-like growth factor (IGF) system in liver diseases. International Journal of Molecular Sciences 19, 1308.CrossRefGoogle ScholarPubMed
Tominaga, K et al. (2017) Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells. Oncogene 36, 1276–1286.CrossRefGoogle ScholarPubMed
Martinez-Quetglas, I et al. (2016) IGF2 is up-regulated by epigenetic mechanisms in hepatocellular carcinomas and is an actionable oncogene product in experimental models. Gastroenterology 151, 1192–1205.CrossRefGoogle ScholarPubMed
Seol, HS et al. (2020) Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma. Scientific Reports 10, 21412.CrossRefGoogle ScholarPubMed
Ashrafizadeh, M et al. (2020) Resveratrol targeting the Wnt signaling pathway: a focus on therapeutic activities. Journal of Cellular Physiology 235, 4135–4145.CrossRefGoogle ScholarPubMed
Tang, L, Wang, D and Gu, D (2018) Knockdown of Sox2 inhibits OS cells invasion and migration via modulating Wnt/β-catenin signaling pathway. Pathology & Oncology Research 24, 907–913.CrossRefGoogle ScholarPubMed
Tang, J et al. (2019) SOX2 Mediates crosstalk between sonic hedgehog and the Wnt/β-catenin signaling pathway to promote proliferation of pituitary adenoma cells. Oncology Letters 18, 81–86.Google ScholarPubMed
Sun, X et al. (2015) MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1. Oncotarget 6, 32944–32954.CrossRefGoogle ScholarPubMed
Migita, T et al. (2017) Epithelial-mesenchymal transition promotes SOX2 and NANOG expression in bladder cancer. Laboratory Investigation 97, 567–576.CrossRefGoogle Scholar
Liu, X et al. (2018) Sox2 promotes tumor aggressiveness and epithelial-mesenchymal transition in tongue squamous cell carcinoma. International Journal of Molecular Medicine 42, 1418–1426.Google ScholarPubMed
Ning, X et al. (2019) Ectopic expression of miR-147 inhibits stem cell marker and epithelial-mesenchymal transition (EMT)-related protein expression in colon cancer cells. Oncology Research 27, 399–406.CrossRefGoogle ScholarPubMed
Lopez-Bertoni, H et al. (2016) Epigenetic modulation of a miR-296-5p:hMGA1 axis regulates Sox2 expression and glioblastoma stem cells. Oncogene 35, 4903–4913.CrossRefGoogle ScholarPubMed
Ozen, M et al. (2015) Overexpression of miR-145-5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression. Cancer Investigation 33, 251–258.CrossRefGoogle ScholarPubMed
Ashrafizadeh, M et al. (2021) New insight towards development of paclitaxel and docetaxel resistance in cancer cells. EMT as a Novel Molecular Mechanism and Therapeutic Possibilities 141, 111824.Google ScholarPubMed
Mirzaei, S et al. (2021) Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: new hope in the fight against cancer. Pharmacol Res 171, 105759. doi: 10.1016/j.phrs.2021.105759.CrossRefGoogle ScholarPubMed
Ashrafizadeh, M et al. (2021) Therapeutic potential of AMPK signaling targeting in lung cancer: advances, challenges and future prospects. Life sciences 278, 119649. doi: 10.1016/j.lfs.2021.119649.CrossRefGoogle ScholarPubMed
Ashrafizadeh, M et al. (2021) Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: new insight to proliferation and metastasis.Life sciences 270, 119006. doi: 10.1016/j.lfs.2020.119006.CrossRefGoogle ScholarPubMed
Liu, B et al. (2020) LncRNA SOX2OT promotes temozolomide resistance by elevating SOX2 expression via ALKBH5-mediated epigenetic regulation in glioblastoma. Cell Death & Disease 11, 384.CrossRefGoogle ScholarPubMed
Huang, C et al. (2018) SOX2 Regulates radioresistance in cervical cancer via the hedgehog signaling pathway. Gynecologic Oncology 151, 533–541.CrossRefGoogle ScholarPubMed
Mirzaei, S et al. (2021) Elucidating role of reactive oxygen Species (ROS) in cisplatin chemotherapy: a focus on molecular pathways and possible therapeutic strategiess. 26, 2382. doi: 10.3390/molecules26082382.CrossRefGoogle Scholar
Cui, F et al. (2020) SOX2 Mediates cisplatin resistance in small-cell lung cancer with downregulated expression of hsa-miR-340-5p. Molecular Genetics & Genomic Medicine 8, e1195.CrossRefGoogle ScholarPubMed
Jin, Y et al. (2016) miR-450b-5p suppresses stemness and the development of chemoresistance by targeting SOX2 in colorectal cancer. DNA and Cell Biology 35, 249–256.CrossRefGoogle ScholarPubMed
Peng, C et al. (2019) MiR-876-3p regulates cisplatin resistance and stem cell-like properties of gastric cancer cells by targeting TMED3. Journal of Gastroenterology and Hepatology 34, 1711–1719.CrossRefGoogle ScholarPubMed
Shakhwar, S et al. (2020) Development and evaluation of paclitaxel nanoemulsion for cancer therapy. Pharmaceutical Development and Technology 25, 510–516.CrossRefGoogle ScholarPubMed
Li, Y et al. (2015) Overexpression of SOX2 is involved in paclitaxel resistance of ovarian cancer via the PI3K/Akt pathway. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine 36, 9823–9828.CrossRefGoogle ScholarPubMed
Li, D et al. (2014) Sox2 is involved in paclitaxel resistance of the prostate cancer cell line PC-3 via the PI3K/Akt pathway. Molecular Medicine Reports 10, 3169–3176.CrossRefGoogle ScholarPubMed
Guan, X and Guan, Y (2020) miR-145-5p attenuates paclitaxel resistance and suppresses the progression in drug-resistant breast cancer cell lines. Neoplasma 67, 972–981.CrossRefGoogle ScholarPubMed
Chen, J et al. (2018) Downregulation of miR-200c-3p contributes to the resistance of breast cancer cells to paclitaxel by targeting SOX2. Oncology Reports 40, 3821–3829.Google Scholar
Jiang, S et al. (2019) MiR-30-5p suppresses cell chemoresistance and stemness in colorectal cancer through USP22/Wnt/β-catenin signaling axis. Journal of Cellular and Molecular Medicine 23, 630–640.CrossRefGoogle ScholarPubMed
Liu, Z et al. (2020) Overexpression of miR-106a enhances oxaliplatin sensitivity of colorectal cancer through regulation of FOXQ1. Oncology Letters 19, 663–670.Google ScholarPubMed
Guo, J et al. (2020) HOTAIR promotes cisplatin resistance of osteosarcoma cells by regulating cell proliferation, invasion, and apoptosis via miR-106a–5p/STAT3 axis. Cell Transplantation 29, 963689720948447.CrossRefGoogle ScholarPubMed
Guo, W et al. (2019) MicroRNA-106a-3p induces apatinib resistance and activates Janus-activated kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) by targeting the SOCS system in gastric cancer. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 25, 10122–10128.CrossRefGoogle ScholarPubMed
Qin, Y et al. (2018) miR-106a reduces 5-fluorouracil (5-FU) sensitivity of colorectal cancer by targeting dual-specificity phosphatases 2 (DUSP2). Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 24, 4944–4951.CrossRefGoogle Scholar
Wang, Z et al. (2020) miR-106b-5p contributes to the lung metastasis of breast cancer via targeting CNN1 and regulating Rho/ROCK1 pathway. Aging 12, 1867–1887.CrossRefGoogle ScholarPubMed
Pan, M et al. (2020) MiR-106b-5p regulates the migration and invasion of colorectal cancer cells by targeting FAT4. Bioscience Reports 40. doi: 10.1042/BSR20200098.CrossRefGoogle ScholarPubMed
Sun, S et al. (2020) Exosomal miR-106b serves as a novel marker for lung cancer and promotes cancer metastasis via targeting PTEN. Life Sciences 244, 117297.CrossRefGoogle ScholarPubMed
Zheng, L et al. (2015) MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer. Journal of Translational Medicine 13, 252.CrossRefGoogle ScholarPubMed
Zhao, C et al. (2015) miR-126 inhibits cell proliferation and induces cell apoptosis of hepatocellular carcinoma cells partially by targeting Sox2. Human Cell 28, 91–99.CrossRefGoogle ScholarPubMed
Elfar, M and Amleh, A (2019) miR-590-3p and its downstream target genes in HCC cell lines. Analytical Cellular Pathology, 2019, 3234812.CrossRefGoogle ScholarPubMed
Ou, C et al. (2020) The potential mechanism of miR-130b on promotion of the invasion and metastasis of hepatocellular carcinoma by inhibiting Notch-Dll1. Journal of Receptor and Signal Transduction Research 40, 157–165.CrossRefGoogle ScholarPubMed
Lu, WC et al. (2016) miR-31 targets ARID1A and enhances the oncogenicity and stemness of head and neck squamous cell carcinoma. Oncotarget 7, 57254–57267. doi: 10.18632/oncotarget.11138.CrossRefGoogle ScholarPubMed
Mohammadi Yeganeh, S et al. (2017) The effect of miR-340 over-expression on cell-cycle-related genes in triple-negative breast cancer cells. Eur J Cancer Care (Engl) 26, e12496.CrossRefGoogle ScholarPubMed
Ramchandani, D et al. (2019) Nanoparticle delivery of miR-708 mimetic impairs breast cancer metastasis. Molecular Cancer Therapeutics 18, 579–591.CrossRefGoogle ScholarPubMed
Lin, QY et al. (2020) miR-638 represses the stem cell characteristics of breast cancer cells by targeting E2F2. Breast Cancer (Tokyo, Japan) 27, 147–158.CrossRefGoogle ScholarPubMed
Wei, Y, Li, H and Qu, Q (2020) miR-484 suppresses endocrine therapy-resistant cells by inhibiting KLF4-induced cancer stem cells in estrogen receptor-positive cancers. Breast Cancer 28, 175–186.CrossRefGoogle ScholarPubMed
Kim, ES et al. (2016) IL-4, a direct target of miR-340/429, is involved in radiation-induced aggressive tumor behavior in human carcinoma cells. Oncotarget 7, 86836–86856.CrossRefGoogle ScholarPubMed
Yang, CM et al. (2015) Expression of the miR-302/367 cluster in glioblastoma cells suppresses tumorigenic gene expression patterns and abolishes transformation related phenotypes. International Journal of Cancer 137, 2296–2309.CrossRefGoogle ScholarPubMed
Deng, Z et al. (2013) The intermediate filament vimentin mediates microRNA miR-378 function in cellular self-renewal by regulating the expression of the Sox2 transcription factor. Journal of Biological Chemistry 288, 319–331.CrossRefGoogle ScholarPubMed
Zhu, G et al. (2015) Upregulation of miR-130b enhances stem cell-like phenotype in glioblastoma by inactivating the Hippo signaling pathway. Biochemical and Biophysical Research Communications 465, 194–199.CrossRefGoogle ScholarPubMed
Sathyan, P et al. (2015) Mir-21-Sox2 axis delineates glioblastoma subtypes with prognostic impact. Journal of Neuroscience 35, 15097–15112.CrossRefGoogle ScholarPubMed
Vinchure, OS et al. (2020) miR-490 suppresses telomere maintenance program and associated hallmarks in glioblastoma. Cellular and Molecular Life Sciences 78, 2299–2314.CrossRefGoogle ScholarPubMed
Chen, J et al. (2020) Long non-coding RNA SNHG1 regulates the Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways via EZH2 to affect the proliferation, apoptosis, and autophagy of prostate cancer cell. Frontiers in Oncology 10, 552907.CrossRefGoogle ScholarPubMed
Shen, Y et al. (2017) MiR-638 acts as a tumor suppressor gene in gastric cancer. Oncotarget 8, 108170–108180.CrossRefGoogle ScholarPubMed
Ma, K et al. (2014) Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells. Molecular Cancer 13, 118.CrossRefGoogle Scholar
Li, J et al. (2013) MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2. Cancer Letters 329, 84–90.CrossRefGoogle ScholarPubMed
Zhang, Y et al. (2018) miR-34a exerts as a key regulator in the dedifferentiation of osteosarcoma via PAI-1-Sox2 axis. Cell Death & Disease 9, 777.CrossRefGoogle ScholarPubMed
Ke, X et al. (2017) MiR-410 induces stemness by inhibiting Gsk3β but upregulating β-catenin in non-small cells lung cancer. Oncotarget 8, 11356–11371.CrossRefGoogle ScholarPubMed
Karatas, OF et al. (2016) Role of miR-145 in human laryngeal squamous cell carcinoma. Head & Neck 38, 260–266.CrossRefGoogle ScholarPubMed
Karatas, OF et al. (2016) The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine 37, 4183–4192.CrossRefGoogle ScholarPubMed
Li, N, Cheng, C and Wang, T (2020) MiR-181c-5p mitigates tumorigenesis in cervical squamous cell carcinoma via targeting glycogen synthase kinase 3β interaction protein (GSKIP). OncoTargets and Therapy 13, 4495–4505.CrossRefGoogle Scholar
Bissey, PA et al. (2020) MiR-34c downregulation leads to SOX4 overexpression and cisplatin resistance in nasopharyngeal carcinoma. BMC Cancer 20, 597.CrossRefGoogle ScholarPubMed
Ma, S et al. (2020) A novel regulatory loop miR-101/ANXA2/EGR1 mediates malignant characteristics of liver cancer stem cells. Carcinogenesis 42, 93–104.CrossRefGoogle Scholar
Wozniak, M, Sztiller-Sikorska, M and Czyz, M (2015) Diminution of miR-340-5p levels is responsible for increased expression of ABCB5 in melanoma cells under oxygen-deprived conditions. Experimental and Molecular Pathology 99, 707–716.CrossRefGoogle ScholarPubMed
Tan, Y et al. (2020) miR-148a regulates the stem cell-like side populations distribution by affecting the expression of ACVR1 in esophageal squamous cell carcinoma. OncoTargets and Therapy 13, 8079–8094.CrossRefGoogle ScholarPubMed
Shi, Z et al. (2015) Decrease of miR-146a is associated with the aggressiveness of human oral squamous cell carcinoma. Archives of Oral Biology 60, 1416–1427.CrossRefGoogle ScholarPubMed
Zuo, Y et al. (2017) Long non-coding RNA MALAT1 promotes proliferation and invasion via targeting miR-129-5p in triple-negative breast cancer. Biomedicine & Pharmacotherapy 95, 922–928.CrossRefGoogle ScholarPubMed
Wang, Y, Hou, Z and Li, D (2018) Long noncoding RNA UCA1 promotes anaplastic thyroid cancer cell proliferation via miR-135a-mediated c-myc activation. Molecular Medicine Reports 18, 3068–3076.Google Scholar
Wu, J et al. (2019) Long non-coding RNA SNHG20 promotes the tumorigenesis of oral squamous cell carcinoma via targeting miR-197/LIN28 axis. Journal of Cellular and Molecular Medicine 23, 680–688.CrossRefGoogle ScholarPubMed
Sheng, Y et al. (2020) Correlation between LncRNA-LINC00659 and clinical prognosis in gastric cancer and study on its biological mechanism. Journal of Cellular and Molecular Medicine 24, 14467–14480.CrossRefGoogle Scholar
Shuai, Y et al. (2020) TEAD4 Modulated LncRNA MNX1-AS1 contributes to gastric cancer progression partly through suppressing BTG2 and activating BCL2. Molecular Cancer 19, 6.CrossRefGoogle ScholarPubMed
Lu, G et al. (2018) Long noncoding RNA LINC00511 contributes to breast cancer tumourigenesis and stemness by inducing the miR-185-3p/E2F1/Nanog axis. Journal of Experimental & Clinical Cancer Research: CR 37, 289.CrossRefGoogle Scholar
Zhang, Z et al. (2018) Long non-coding RNA FEZF1-AS1 promotes breast cancer stemness and tumorigenesis via targeting miR-30a/Nanog axis. Journal of Cellular Physiology 233, 8630–8638.CrossRefGoogle ScholarPubMed
Xia, F, Xiong, Y and Li, Q (2017) Interaction of lincRNA ROR and p53/miR-145 correlates with lung cancer stem cell signatures. Journal of Cellular Biochemistry [not published yet]. https://onlinelibrary.wiley.com/doi/10.1002/jcb.25960CrossRefGoogle ScholarPubMed
Zhang, M et al. (2019) LncRNA FOXD2-AS1 regulates miR-25-3p/Sema4c axis to promote the invasion and migration of colorectal cancer cells. Cancer Management and Research 11, 10633–10639.CrossRefGoogle ScholarPubMed
Dou, X et al. (2019) Long noncoding RNA FOXD2-AS1 promotes the malignancy of cervical cancer by sponging microRNA-760 and upregulating hepatoma-derived growth factor. Frontiers in Pharmacology 10, 1700.CrossRefGoogle ScholarPubMed
Jiang, M et al. (2019) Long non-coding RNA FOXD2-AS1/miR-150-5p/PFN2 axis regulates breast cancer malignancy and tumorigenesis. International Journal of Oncology 54, 1043–1052.Google Scholar
Lee, JH et al. (2020) Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma. Journal of Advanced Research 26, 83–94.CrossRefGoogle ScholarPubMed
Hwang, ST et al. (2020) Corilagin represses epithelial to mesenchymal transition process through modulating Wnt/β-catenin signaling cascade. Biomolecules 10, 1406.CrossRefGoogle ScholarPubMed
Ji, L et al. (2020) LINC01413/hnRNP-K/ZEB1 axis accelerates cell proliferation and EMT in colorectal cancer via inducing YAP1/TAZ1 translocation. Molecular Therapy. Nucleic Acids 19, 546–561.CrossRefGoogle ScholarPubMed
Feng, T et al. (2020) The microRNA-708-5p/ZEB1/EMT axis mediates the metastatic potential of osteosarcoma. Oncology Reports 43, 491–502.Google Scholar
Gao, Y et al. (2017) Linc-DYNC2H1-4 promotes EMT and CSC phenotypes by acting as a sponge of miR-145 in pancreatic cancer cells. Cell Death & Disease 8, e2924.CrossRefGoogle ScholarPubMed
Keshavarz, M and Asadi, MH (2019) Long non-coding RNA ES1 controls the proliferation of breast cancer cells by regulating the Oct4/Sox2/miR-302 axis. FEBS Journal 286, 2611–2623.CrossRefGoogle ScholarPubMed
Li, W et al. (2020) LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas. Oncogene 39, 3879–3892.CrossRefGoogle ScholarPubMed
Gao, Z et al. (2020) Regulatory effects of lncRNA ATB targeting miR-200c on proliferation and apoptosis of colorectal cancer cells. Journal of Cellular Biochemistry 121, 332–343.CrossRefGoogle ScholarPubMed
Zheng, X et al. (2019) Long noncoding RNA-ATB impairs the function of tumor suppressor miR-126-mediated signals in endometrial cancer for tumor growth and metastasis. Cancer Biotherapy & Radiopharmaceuticals 34, 47–55.CrossRefGoogle ScholarPubMed
Cui, M et al. (2019) Non-coding RNA Pvt1 promotes cancer stem cell-like traits in nasopharyngeal cancer via inhibiting miR-1207. Pathology & Oncology Research 25, 1411–1422.CrossRefGoogle ScholarPubMed
Sun, Q et al. (2019) LncRNA LOXL1-AS1 facilitates the tumorigenesis and stemness of gastric carcinoma via regulation of miR-708-5p/USF1 pathway. Cell Proliferation 52, e12687.CrossRefGoogle ScholarPubMed
Zhang, Q et al. (2020) LOXL2 Upregulation in gliomas drives tumorigenicity by activating autophagy to promote TMZ resistance and trigger EMT. Frontiers in Oncology 10, 569584.CrossRefGoogle ScholarPubMed
Li, Z et al. (2019) Modulating lncRNA SNHG15/CDK6/miR-627 circuit by palbociclib, overcomes temozolomide resistance and reduces M2-polarization of glioma associated microglia in glioblastoma multiforme. Journal of Experimental & Clinical Cancer Research: CR 38, 380.CrossRefGoogle ScholarPubMed
Tao, W et al. (2019) LncRNA DANCR contributes to tumor progression via targetting miR-216a-5p in breast cancer: lncRNA DANCR contributes to tumor progression. Bioscience Reports 39. doi: 10.1042/BSR20181618.CrossRefGoogle ScholarPubMed
Wu, G et al. (2020) LncRNA DANCR upregulation induced by TUFT1 promotes malignant progression in triple negative breast cancer via miR-874-3p-SOX2 axis. Experimental Cell Research 396, 112331.CrossRefGoogle ScholarPubMed
Domvri, K et al. (2020) Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance via immunosuppressive miR-182/miR-217 signaling and p27/CDK6 regulation. Oncotarget 11, 2847–2862.CrossRefGoogle ScholarPubMed
Sun, B et al. (2020) Long non-coding RNA SNHG3, induced by IL-6/STAT3 transactivation, promotes stem cell-like properties of gastric cancer cells by regulating the miR-3619-5p/ARL2 axis. Cellular Oncology 44, 179–192.CrossRefGoogle ScholarPubMed
Han, L et al. (2020) LncRNA HOTTIP facilitates the stemness of breast cancer via regulation of miR-148a-3p/WNT1 pathway. Journal of Cellular and Molecular Medicine 24, 6242–6252.CrossRefGoogle ScholarPubMed
Lorenzato, A et al. (2020) Vitamin C restricts the emergence of acquired resistance to EGFR-targeted therapies in colorectal cancer. Cancers 12. doi: 10.3390/cancers12030685.CrossRefGoogle ScholarPubMed
Gregoraszczuk, EL et al. (2020) Vitamin C supplementation had no side effect in non-cancer, but had anticancer properties in ovarian cancer cells. International Journal for Vitamin and Nutrition Research 91, 293–303. doi: 10.1024/0300-9831/a000634.CrossRefGoogle ScholarPubMed
Ramezankhani, B, Taha, MF and Javeri, A (2019) Vitamin C counteracts miR-302/367-induced reprogramming of human breast cancer cells and restores their invasive and proliferative capacity. Journal of Cellular Physiology 234, 2672–2682.CrossRefGoogle ScholarPubMed
Slingerland, M et al. (2013) Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials. Investigational New Drugs 31, 1087–1094.CrossRefGoogle ScholarPubMed
Kim, NY et al. (2020) Bufalin down-regulates Axl expression to inhibit cell proliferation and induce apoptosis in non-small-cell lung cancer cells. Bioscience Reports 40. doi: 10.1042/BSR20193959.CrossRefGoogle ScholarPubMed
Qian, L et al. (2020) Anti-tumor activity of bufalin by inhibiting c-MET mediated MEK/ERK and PI3K/AKT signaling pathways in gallbladder cancer. Journal of Cancer 11, 3114–3123.CrossRefGoogle ScholarPubMed
Su, S et al. (2021) Bufalin inhibits ovarian carcinoma via targeting mTOR/HIF-α pathway. Basic & Clinical Pharmacology & Toxicology 128, 224–233.CrossRefGoogle ScholarPubMed
Liu, T et al. (2017) Bufalin inhibits cellular proliferation and cancer stem cell-like phenotypes via upregulation of MiR-203 in glioma. Cellular Physiology and Biochemistry 44, 671–681.CrossRefGoogle ScholarPubMed
Chen, YJ et al. (2013) Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. PLoS ONE 8, e82751.CrossRefGoogle ScholarPubMed
Yue, PY et al. (2012) Review of biological and pharmacological activities of the endemic Taiwanese bitter medicinal mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (higher Basidiomycetes). International Journal of Medicinal Mushrooms 14, 241–256.CrossRefGoogle Scholar
Yeh, CT et al. (2009) Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells. Cancer Letters 285, 73–79.CrossRefGoogle ScholarPubMed
Huang, YJ et al. (2019) Antrodia cinnamomea enhances chemo-sensitivity of 5-FU and suppresses colon tumorigenesis and cancer stemness via up-regulation of tumor suppressor miR-142-3p. Biomolecules 9. doi: 10.3390/biom9080306.CrossRefGoogle ScholarPubMed
Chen, JH et al. (2019) Ovatodiolide suppresses oral cancer malignancy by down-regulating exosomal Mir-21/STAT3/β-catenin cargo and preventing oncogenic transformation of normal gingival fibroblasts. Cancers 12. doi: 10.3390/cancers12010056.CrossRefGoogle ScholarPubMed
Ashrafizadeh, M et al. (2020) Progress in delivery of siRNA-based therapeutics employing Nano-vehicles for treatment of prostate cancer. Bioengineering 7, 91.CrossRefGoogle ScholarPubMed
Jia, D et al. (2020) Anticancer effects of ovatodiolide on human prostate cancer cells involves cell cycle arrest, apoptosis and blocking of Ras/Raf/MEK/ERK signaling pathway. Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology 25, 2412–2417.Google ScholarPubMed
Tu, YX et al. (2018) Ovatodiolide targets chronic myeloid leukemia stem cells by epigenetically upregulating hsa-miR-155, suppressing the BCR-ABL fusion gene and dysregulating the PI3K/AKT/mTOR pathway. Oncotarget 9, 3267–3277.CrossRefGoogle ScholarPubMed
Ashrafizadeh, M et al. (2020) Polychemotherapy with curcumin and doxorubicin via biological nanoplatforms: enhancing antitumor activity 12, 1084.CrossRefGoogle Scholar
Ashrafizadeh, M et al. (2020) Versatile role of curcumin and its derivatives in lung cancer therapy 235, 9241–9268.CrossRefGoogle Scholar
Tahmasebi Mirgani, M et al. (2014) Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells. International Journal of Nanomedicine 9, 403–417.Google ScholarPubMed
Fu, J et al. (2013) NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200. Neuro-Oncology 15, 691–706.CrossRefGoogle ScholarPubMed
Zhang, Q et al. (2015) Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis. Oncotarget 6, 37335–37348.CrossRefGoogle ScholarPubMed
Kuo, IY et al. (2019) SOX17 Overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes. Journal of Biomedical Science 26, 20.CrossRefGoogle ScholarPubMed
Xiong, X et al. (2021) miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway. Cellular Signalling 77, 109818.CrossRefGoogle ScholarPubMed
Kuo, IY et al. (2014) Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression. International Journal of Cancer 135, 563–573.CrossRefGoogle ScholarPubMed
Li, Y et al. (2015) The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer. Oncotarget 6, 9099–9112.CrossRefGoogle ScholarPubMed
Zhou, Q et al. (2020) The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis. Oncogene 39, 1414–1428.CrossRefGoogle ScholarPubMed
Lin, C et al. (2020) PTPRA Facilitates cancer growth and migration via the TNF-α-mediated PTPRA-NF-κB pathway in MCF-7 breast cancer cells. Oncology Letters 20, 131.CrossRefGoogle ScholarPubMed
Yao, J et al. (2020) TNF-α/miR-155 axis induces the transformation of osteosarcoma cancer stem cells independent of TP53INP1. Gene 726, 144224.CrossRefGoogle ScholarPubMed
Chen, C et al. (2018) NF-κB-regulated miR-155, via repression of QKI, contributes to the acquisition of CSC-like phenotype during the neoplastic transformation of hepatic cells induced by arsenite. Molecular Carcinogenesis 57, 483–493.CrossRefGoogle ScholarPubMed
He, P and Ding, J (2020) EWS Promotes cell proliferation and inhibits cell apoptosis by regulating miR-199a-5p/Sox2 axis in osteosarcoma. Biotechnology Letters 42, 1263–1274.CrossRefGoogle ScholarPubMed
Donzelli, S et al. (2020) Paracrine signaling from breast cancer cells causes activation of ID4 expression in tumor-associated macrophages. Cells 9, 418.CrossRefGoogle ScholarPubMed
Jeon, HM et al. (2011) ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9*-mediated suppression of SOX2. Cancer Research 71, 3410–3421.CrossRefGoogle ScholarPubMed
Caiment, F et al. (2015) High-throughput data integration of RNA-miRNA-circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity. Nucleic Acids Research 43, 2525–2534.CrossRefGoogle ScholarPubMed
Chen, LL and Yang, L (2015) Regulation of circRNA biogenesis. RNA Biology 12, 381–388.CrossRefGoogle ScholarPubMed
Cai, H et al. (2018) Hsa_circ_0103809 promotes cell proliferation and inhibits apoptosis in hepatocellular carcinoma by targeting miR-490-5p/SOX2 signaling pathway. American Journal of Translational Research 10, 1690–1702.Google ScholarPubMed
Zhao, Y et al. (2020) CircRNA CDR1as/miR-641/HOXA9 pathway regulated stemness contributes to cisplatin resistance in non-small cell lung cancer (NSCLC). Cancer Cell International 20, 289.CrossRefGoogle Scholar
Yang, Y et al. (2020) Tumor microenvironment in ovarian cancer: function and therapeutic strategy. Frontiers in Cell and Developmental Biology 8, 758.CrossRefGoogle ScholarPubMed
Jiang, Y, Wang, C and Zhou, S (2020) Targeting tumor microenvironment in ovarian cancer: premise and promise. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1873, 188361.CrossRefGoogle ScholarPubMed
Hanahan, D and Weinberg, RA (2011) Hallmarks of cancer: the next generation. Cell 144, 646–674.CrossRefGoogle ScholarPubMed
Bader, JE, Voss, K and Rathmell, JC (2020) Targeting metabolism to improve the tumor microenvironment for cancer immunotherapy. Molecular Cell 78, 1019–1033.CrossRefGoogle ScholarPubMed
Pavlova, NN and Thompson, CB (2016) The emerging hallmarks of cancer metabolism. Cell Metabolism 23, 27–47.CrossRefGoogle ScholarPubMed
DeBerardinis, RJ and Chandel, NS (2016) Fundamentals of cancer metabolism. Science Advances 2, e1600200.CrossRefGoogle ScholarPubMed
Hanahan, D and Coussens, LM (2012) Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21, 309–322.CrossRefGoogle ScholarPubMed
Quail, DF and Joyce, JA (2013) Microenvironmental regulation of tumor progression and metastasis. Nature Medicine 19, 1423–1437.CrossRefGoogle ScholarPubMed
Xiong, Q et al. (2020) Hypoxia and cancer related pathology. Cancer Letters 486, 1–7.CrossRefGoogle ScholarPubMed
Ma, Z et al. (2021) Targeting hypoxia-inducible factor-1-mediated metastasis for cancer therapy. 34, 1484–1497. doi: 10.1089/ars.2019.7935.CrossRefGoogle Scholar
Bister, N et al. (2020) Hypoxia and extracellular vesicles: a review on methods, vesicular cargo and functions. Journal of Extracellular Vesicles 10, e12002.CrossRefGoogle ScholarPubMed
Rius, J et al. (2008) NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature 453, 807–811.CrossRefGoogle ScholarPubMed
Hudson, CC et al. (2002) Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin. Molecular and Cellular Biology 22, 7004–7014.CrossRefGoogle ScholarPubMed
Noman, MZ et al. (2009) The cooperative induction of hypoxia-inducible factor-1α and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis. The Journal of Immunology 182, 3510–3521.CrossRefGoogle ScholarPubMed
Wang, Y et al. (2019) SOX2 promotes hypoxia-induced breast cancer cell migration by inducing NEDD9 expression and subsequent activation of Rac1/HIF-1α signaling. Cellular & Molecular Biology Letters 24, 55.CrossRefGoogle ScholarPubMed
Bae, KM et al. (2016) Hypoxia regulates SOX2 expression to promote prostate cancer cell invasion and sphere formation. American Journal of Cancer Research 6, 1078–1088.Google ScholarPubMed
Mou, W et al. (2015) Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment. Cancer Letters 358, 115–123.CrossRefGoogle ScholarPubMed
Lei, X et al. (2020) HMGB1 Release promotes paclitaxel resistance in castration-resistant prostate cancer cells via activating c-Myc expression. Cellular Signalling 72, 109631.CrossRefGoogle ScholarPubMed
Sánchez-González, I et al. (2020) miR-149 suppresses breast cancer metastasis by blocking paracrine interactions with macrophages. Cancer Research 80, 1330–1341.CrossRefGoogle ScholarPubMed
Roscigno, G et al. (2020) miR-216a acts as a negative regulator of breast cancer by modulating stemness properties and tumor microenvironment. International Journal of Molecular Sciences 21, 2313.CrossRefGoogle ScholarPubMed
Chuang, HY et al. (2019) Preclinical evidence of STAT3 inhibitor pacritinib overcoming temozolomide resistance via downregulating miR-21-enriched exosomes from M2 glioblastoma-associated macrophages. Journal of Clinical Medicine 8, 959.CrossRefGoogle ScholarPubMed
Brockmueller, A et al. (2021) Resveratrol's anti-cancer effects through the modulation of tumor glucose metabolism. Cancers 13, 188.CrossRefGoogle ScholarPubMed
Zhai, K et al. (2020) Curcumin's beneficial effects on neuroblastoma: mechanisms, challenges, and potential solutions. Biomolecules 10, 1469.CrossRefGoogle ScholarPubMed
Liskova, A et al. (2020) Implications of flavonoids as potential modulators of cancer neovascularity. Journal of Cancer Research and Clinical Oncology, 1–18. doi: 10.1007/s00432-020-03383-810.Google ScholarPubMed
Varghese, E et al. (2020) Targeting glucose metabolism to overcome resistance to anticancer chemotherapy in breast cancer. Cancers 12, 2252.CrossRefGoogle ScholarPubMed
Buhrmann, C et al. (2020) Targeting NF-κB signaling by calebin a, a compound of turmeric, in multicellular tumor microenvironment: potential role of apoptosis induction in CRC cells. Biomedicines 8, 236.CrossRefGoogle ScholarPubMed
Li, X et al. (2012) Expression of Sox2 and Oct4 and their clinical significance in human non-small-cell lung cancer. International Journal of Molecular Sciences 13, 7663–7675.CrossRefGoogle ScholarPubMed
Sun, C et al. (2013) Sox2 expression predicts poor survival of hepatocellular carcinoma patients and it promotes liver cancer cell invasion by activating slug. Medical Oncology 30, 503.CrossRefGoogle ScholarPubMed
Jakubauskienė, E et al. (2015) Gastrointestinal tract tumors and cell lines possess differential splicing factor expression and tumor associated mRNA isoform formation profiles. Cancer Biomarkers: Section A of Disease Markers 15, 575–581.CrossRefGoogle ScholarPubMed