Pathological implications of cell cycle re-entry in Alzheimer disease

David J. Bonda; Hyun-pil Lee; Wataru Kudo; Xiongwei Zhu; Mark A. Smith; Hyoung-gon Lee

doi:10.1017/S146239941000150X

Pathological implications of cell cycle re-entry in Alzheimer disease

Published online by Cambridge University Press: 29 June 2010

Mark A. Smith and

David J. Bonda: Affiliation:
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Hyun-pil Lee: Affiliation:
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Wataru Kudo: Affiliation:
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Xiongwei Zhu: Affiliation:
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Mark A. Smith*: Affiliation:
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Hyoung-gon Lee: Affiliation:
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
*: *Corresponding author: Mark A. Smith, Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA. E-mail: mark.smith@case.edu

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Abstract

The complex neurodegeneration underlying Alzheimer disease (AD), although incompletely understood, is characterised by an aberrant re-entry into the cell cycle in neurons. Pathological evidence, in the form of cell cycle markers and regulatory proteins, suggests that cell cycle re-entry is an early event in AD, which precedes the formation of amyloid-β plaques and neurofibrillary tangles (NFTs). Although the exact mechanisms that induce and mediate these cell cycle events in AD are not clear, significant advances have been made in further understanding the pathological role of cell cycle re-entry in AD. Importantly, recent studies indicate that cell cycle re-entry is not a consequence, but rather a cause, of neurodegeneration, suggesting that targeting of cell cycle re-entry may provide an opportunity for therapeutic intervention. Moreover, multiple inducers of cell cycle re-entry and their interactions in AD have been proposed. Here, we review the most recent advances in understanding the pathological implications of cell cycle re-entry in AD.

Type: Review Article
Information: Expert Reviews in Molecular Medicine , Volume 12 , January 2010 , e19

DOI: https://doi.org/10.1017/S146239941000150X [Opens in a new window]
Copyright: Copyright © Cambridge University Press 2010

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Pathological implications of cell cycle re-entry in Alzheimer disease

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