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Toll-like receptors and intestinal defence: molecular basis and therapeutic implications
Published online by Cambridge University Press: 13 February 2004
Abstract
Toll-like receptors (TLRs) play a principle role in distinct pathogen recognition and in the initiation of innate immune responses of the intestinal mucosa. Activated innate immunity interconnects downstream with adaptive immunity in complex feedback regulatory loops. Intestinal disease might result from inappropriate activation of the mucosal immune system driven by TLRs in response to normal luminal flora.
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- © Cambridge University Press 2003
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