Expert Reviews in Molecular Medicine: Volume 4 - Issue 5

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Volume 4 - Issue 5 - 5 March 2002

Contents

Review Article

Chagas disease: role of parasite genetic variation in pathogenesis
Andréa M. Macedo, Riva P. Oliveira, Sérgio D.J. Pena
Published online by Cambridge University Press:

13 February 2004, pp. 1-16
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Chagas disease, caused by the parasite protozoan Trypanosoma cruzi, is characterised by a variable clinical course, from symptomless cases to severe chronic disease with cardiac and/or gastrointestinal involvement. This variability has been attributed both to differences in the host response and to genomic heterogeneity of the parasite. This article reviews the evidence in favour of an important role of the genetic constitution of T. cruzi in determining the clinical characteristics of Chagas disease and discusses the basis of the ‘Clonal-Histotropic Model’ for the pathogenesis of this disease.

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Volume 4 - Issue 5 - 5 March 2002

Review Article

Chagas disease: role of parasite genetic variation in pathogenesis

Expert Reviews in Molecular Medicine

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Volume 4 - Issue 5 - 5 March 2002

Review Article

Chagas disease: role of parasite genetic variation in pathogenesis