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CONGENITAL URINARY BLADDER OUTLET OBSTRUCTION

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  12 January 2010

MARIE-KLAIRE FARRUGIA  and
ADRIAN S WOOLF
MARIE-KLAIRE FARRUGIA
Affiliation:
Nephro-Urology Unit, UCL Institute of Child Health, London, United Kingdom
ADRIAN S WOOLF*
Affiliation:
Nephro-Urology Unit, UCL Institute of Child Health, London, United Kingdom
*
Professor Adrian S Woolf, Nephro-Urology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom. Email address: a.woolf@ich.ucl.ac.uk
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Extract

The term congenital ‘bladder outlet obstruction (BOO)’ describes the collection of conditions in which the normal, urethral egress of urine from the fetal bladder is impaired. The term is interchangeable with fetal ‘lower urinary tract obstruction’, as used by other authors. After considering normal urinary tract embryology, we describe the epidemiology of congenital BOO and the primary anatomical disorders associated with it. We then proceed to describe its fetal and postnatal clinical manifestations and then consider therapies and interventions which have been used to manage the condition. We not only focus on urethral and bladder disease with constitutes BOO itself, but also describe associated kidney disorders which, via chronic renal excretory failure, are important causes of morbidity. Rather than provide an exhaustive review, we emphasise studies published in the last decade, and therefore readers are referred to other reviews citing numerous earlier references.

Type
Research Article
Information
Fetal and Maternal Medicine Review , Volume 21 , Issue 1 , February 2010 , pp. 55 - 73
Copyright
Copyright © Cambridge University Press 2010

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References

REFERENCES

1Anumba, DO, Scott, JE, Plant, ND, Robson, SC. Diagnosis and outcome of fetal lower urinary tract obstruction in the northern region of England. Prenat Diagn 2005; 25: 7–13.CrossRefGoogle ScholarPubMed
2Morris, RK, Kilby, MD. An overview of the literature on congenital lower urinary tract obstruction and introduction to the PLUTO trial: percutaneous shunting in lower urinary tract obstruction. Aust N Z J Obstet Gynaecol 2009; 49: 6–10.CrossRefGoogle Scholar
3Woolf, AS, Thiruchelvam, N. Congenital obstructive uropathy: its origin and contribution to end-stage renal disease in children. Adv Ren Replace Ther 2001; 8: 157–63.CrossRefGoogle ScholarPubMed
4Krishnan, A, de Souza, A, Konijeti, R, Baskin, LS. The anatomy and embryology of posterior urethral valves. J Urol 2006; 175: 1214–220.CrossRefGoogle ScholarPubMed
5Becker, A, Baum, M. Obstructive uropathy. Early Hum Dev 2006; 82: 15–22.CrossRefGoogle ScholarPubMed
6Lissauer, D, Morris, RK, Kilby, MD. Fetal lower urinary tract obstruction. Semin Fetal Neonatal Med 2007; 12: 464–70.CrossRefGoogle ScholarPubMed
7Morris, RK, Kilby, MD. Congenital urinary tract obstruction. Best Pract Res Clin Obstet Gynaecol 2008; 22: 97–122.CrossRefGoogle ScholarPubMed
8Kerecuk, L, Schreuder, MF, Woolf, AS. Renal tract malformations: perspectives for nephrologists. Nat Clin Pract Nephrol 2008; 4: 312–25.CrossRefGoogle ScholarPubMed
9Woolf, AS, Jenkins, D. Chapter 2. Development of the kidney. In: Jennette, JC, Olson, JL, Schwartz, MM, Silva, FG (eds). Heptinstall's Pathology of the Kidney. 6th edition.Lippincott-Raven, Philadelphia-New York, USA. 2006; 71–95.Google Scholar
10Woolf, AS, Pitera, JE. Embryology. In: Avner, ED, Harmon, WE, Niaudet, P. (eds) Pediatric Nephrology. 6th Edition. Springer-Verlag, Berlin, Heidelberg. 2009: 3–30.CrossRefGoogle Scholar
11Jenkins, D, Winyard, PJ, Woolf, AS. Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J Anat 2007; 211: 620–29.CrossRefGoogle ScholarPubMed
12Tacciuoli, M, Lotti, T, de Matteis, A, Laurenti, C. Development of the smooth muscle of the ureter and vesical trigone: histological investigation in human fetus. Eur Urol 1975; 1: 282–86.Google ScholarPubMed
13Matsuno, T, Tokunaka, S, Koyanagi, T. Muscular development in the urinary tract. J Urol 1984; 132: 148–152.CrossRefGoogle ScholarPubMed
14Caubit, X, Lye, CM, Martin, E, Coré, N, Long, DA, Vola, C et al. Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development 2008; 135: 3301–310.CrossRefGoogle ScholarPubMed
15Seifert, AW, Harfe, BD, Cohn, MJ. Cell lineage analysis demonstrates an endodermal origin of the distal urethra and perineum. Dev Biol 2008; 318: 143–52.CrossRefGoogle ScholarPubMed
16Lee, SM, Park, SK, Shim, SS, Jun, JK, Park, JS, Syn, HC. Measurement of fetal urine production by three-dimensional ultrasonography in normal pregnancy. Ultrasound Obstet Gynecol 2007; 30: 281–86.CrossRefGoogle ScholarPubMed
17Wiesel, A, Queisser-Luft, A, Clementi, M, Bianca, S, Stoll, C; EUROSCAN Study Group. Prenatal detection of congenital renal malformations by fetal ultrasonographic examination: an analysis of 709,030 births in 12 European countries. Eur J Med Genet 2005; 48: 131–44.CrossRefGoogle ScholarPubMed
18Lewis, MA, Shaw, J, Sinha, M, Adalat, S, Hussain, F, Inward, C. UK Renal Registry 11th Annual Report: Chapter 13 Demography of the UK paediatric renal replacement therapy population. Nephron Clin Pract 2009; 111 (Suppl 1): c257–c267.CrossRefGoogle Scholar
19Toiviainen-Salo, S, Garel, L, Grignon, A, Dubois, J, Rypens, F, Boisvert, J et al. Fetal hydronephrosis: is there hope for consensus? Pediatr Radiol 2004; 34: 519–29.CrossRefGoogle ScholarPubMed
20Gunn, TR, Mora, JD, Pease, P. Antenatal diagnosis of urinary tract abnormalities by ultrasonography after 28 weeks’ gestation: incidence and outcome. Am J Obstet Gynecol 1995; 172: 479–86.CrossRefGoogle ScholarPubMed
21González, R, De Filippo, R, Jednak, R, Barthold, JS. Urethral atresia: long-term outcome in 6 children who survived the neonatal period. J Urol 2001; 165: 2241–244.CrossRefGoogle ScholarPubMed
22Eagle, JF, Barrett, MD. Congenital deficiency of abdominal musculature with associated genitourinary abnormalities: a syndrome. Pediatrics 1950; 6: 721–36.CrossRefGoogle ScholarPubMed
23Stephens, FD, Gupta, D. Pathogenesis of the prune belly syndrome. J Urol 1994; 152: 2328–331.CrossRefGoogle ScholarPubMed
24Volmar, KE, Fritsch, MK, Perlman, EJ, Hutchins, GM. Patterns of congenital lower urinary tract obstructive uropathy: relation to abnormal prostate and bladder development and the prune belly syndrome. Pediatr Dev Pathol 2001; 4: 467–72.CrossRefGoogle ScholarPubMed
25Nouaili, EB, Chaouachi, S, Nouira, F, Benmassoud, I, Laabidi, K, Chaouachi, B et al. Concordant posterior urethral valves in male monochorionic twins with secondary prune belly syndrome. Tunis Med 2008; 86: 1086–1088.Google ScholarPubMed
26Weber, S, Mir, S, Schlingmann, KP, Nürnberg, G, Becker, C, Kara, PE et al. Gene locus ambiguity in posterior urethral valves/prune-belly syndrome. Pediatr Nephrol 2005; 20: 1036–1042.CrossRefGoogle ScholarPubMed
27Yiee, J, Wilcox, D. Abnormalities of the fetal bladder. Semin Fetal Neonatal Med 2008; 13: 164–70.CrossRefGoogle ScholarPubMed
28Lashley, DB, Masliah, E, Kaplan, GW, McAleer, IM. Megacystis microcolon intestinal hypoperistalsis syndrome: bladder distension and pyelectasis in the fetus without anatomic outflow obstruction. Urology 2000; 55: 774.CrossRefGoogle ScholarPubMed
29Levin, TL, Soghier, L, Blitman, NM, Vega-Rich, C, Nafday, S. Megacystis-microcolon-intestinal hypoperistalsis and prune belly: overlapping syndromes. Pediatr Radiol 2004; 34: 995–98.CrossRefGoogle ScholarPubMed
30Schreuder, MF, Van Der Horst, HJ, Bökenkamp, A, Beckers, GM, van Wijk, JA. Posterior urethral valves in three siblings: a case report and review of the literature. Birth Defects Res A Clin Mol Teratol 2008; 82: 232–35.CrossRefGoogle ScholarPubMed
31Donnenfeld, AE, Lockwood, D, Custer, T, Lamb, AN. Prenatal diagnosis from fetal urine in bladder outlet obstruction: success rates for traditional cytogenetic evaluation and interphase fluorescence in situ hybridization. Genet Med 2002; 4: 444–47.CrossRefGoogle ScholarPubMed
32Liao, AW, Sebire, NJ, Geerts, L, Cicero, S, Nicolaides, KH. Megacystis at 10–14 weeks of gestation: chromosomal defects and outcome according to bladder length. Ultrasound Obstet Gynecol 2003; 21: 338–41.CrossRefGoogle ScholarPubMed
33Palacios, A, Pedro Carvalho, A, de Castro, R, Reis, A. Goldenhar syndrome associated to posterior urethral valves. Arch Esp Urol 2007; 60: 69–71.CrossRefGoogle ScholarPubMed
34Salerno, A, Kohlhase, J, Kaplan, BS. Townes-Brockes syndrome and renal dysplasia: a novel mutation in the SALL1 gene. Pediatr Nephrol 2000; 14: 25–28.CrossRefGoogle ScholarPubMed
35Krapp, M, Geipel, A, Germer, U, Krokowski, M, Gembruch, U. First-trimester sonographic diagnosis of distal urethral atresia with megalourethra in VACTERL association. Prenat Diagn 2002; 22: 422–24.CrossRefGoogle ScholarPubMed
36Sinico, M, Touboul, C, Haddad, B, Encha-Razavi, F, Paniel, JB, Gicquel, C et al. Giant omphalocele and “prune belly” sequence as components of the Beckwith-Wiedemann syndrome. Am J Med Genet 2004; 129A: 198–200.CrossRefGoogle ScholarPubMed
37Workman, SJ, Kogan, BA. Fetal bladder histology in posterior urethral valves and the prune belly syndrome. J Urol 1990; 144: 337–39.CrossRefGoogle ScholarPubMed
38Dumez, Y, Gubler, MC. Development of human fetal kidney in obstructive uropathy: correlations with ultrasonography and urine biochemistry. Kidney Int 1997; 52: 21–32.Google Scholar
39Poucell-Hatton, S, Huang, M, Bannykh, S, Benirschke, K, Masliah, E. Fetal obstructive uropathy: patterns of renal pathology. Pediatr Dev Pathol 2000; 3: 223–31.CrossRefGoogle ScholarPubMed
40Shimada, K, Hosokawa, S, Tohda, A, Matsumoto, F, Johnin, K. Histology of the fetal prune belly syndrome with reference to the efficacy of prenatal decompression. Int J Urol 2000; 7: 161–66.CrossRefGoogle Scholar
41Farrugia, MK, Long, DA, Godley, ML, Peebles, DM, Fry, CH, Cuckow, PM et al. Experimental short-term fetal bladder outflow obstruction: I. Morphology and cell biology associated with urinary flow impairment. J Pediatr Urol 2006; 2: 243–53.CrossRefGoogle ScholarPubMed
42Farrugia, MK, Godley, ML, Woolf, AS, Peebles, DM, Cuckow, PM, Fry, CH. Experimental short-term partial fetal bladder outflow obstruction: II. Compliance and contractility associated with urinary flow impairment. J Pediatr Urol 2006; 2: 254–60.CrossRefGoogle ScholarPubMed
43Thiruchelvam, N, Wu, C, David, A, Woolf, AS, Cuckow, PM, Fry, CH. Neurotransmission and viscoelasticity in the ovine fetal bladder after in utero bladder outflow obstruction. Am J Physiol Regul Integr Comp Physiol 2003; 284: R1296–R1305.CrossRefGoogle ScholarPubMed
44Thiruchelvam, N, Nyirady, P, Peebles, DM, Fry, CH, Cuckow, PM, Woolf, AS. Urinary outflow obstruction increases apoptosis and deregulates Bcl-2 and Bax expression in the fetal ovine bladder. Am J Pathol 2003; 162: 1271–282.CrossRefGoogle ScholarPubMed
45Gonzalez, R, Reinberg, Y, Burke, B, Wells, T, Vernier, RL. Early bladder outlet obstruction in fetal lambs induces renal dysplasia and the prune-belly syndrome. J Pediatr Surg 1990; 25: 342–45.CrossRefGoogle ScholarPubMed
46Farrugia, MK, Woolf, AS, Fry, CH, Peebles, DM, Cuckow, PM, Godley, ML. Radiotelemetered urodynamics of obstructed ovine fetal bladders: correlations with ex vivo cystometry and renal histopathology. BJU Int 2007; 99: 1517–522.CrossRefGoogle ScholarPubMed
47Peters, CA, Carr, MC, Lais, A, Retik, AB, Mandell, J. The response of the fetal kidney to obstruction. J Urol 1992; 148: 503–509.CrossRefGoogle ScholarPubMed
48Kitagawa, H, Pringle, KC, Koike, J, Zuccollo, J, Seki, Y, Wakisaka, M et al. Vesicoamniotic shunt for complete urinary tract obstruction is partially effective. J Pediatr Surg 2006; 41: 394–402.CrossRefGoogle ScholarPubMed
49Yang, SP, Woolf, AS, Quinn, F, Winyard, PJ. Deregulation of renal transforming growth factor-b1 after experimental short-term ureteric obstruction in fetal sheep. Am J Pathol 2001; 159: 109–17.CrossRefGoogle Scholar
50Yang, SP, Woolf, AS, Yuan, HT, Scott, RJ, Risdon, RA, O'Hare, MJ et al. Potential biological role of transforming growth factor-b1 in human congenital kidney malformations. Am J Pathol 2000; 157: 1633–647.CrossRefGoogle Scholar
51Moessinger, AC, Harding, R, Adamson, TM, Singh, M, Kiu, GT. Role of lung fluid volume in growth and maturation of the fetal sheep lung. J Clin Invest 1990; 86: 1270–277.CrossRefGoogle ScholarPubMed
52Edouga, D, Hugueny, B, Gasser, B, Bussières, L, Laborde, K. Recovery after relief of fetal urinary obstruction: morphological, functional and molecular aspects. Am J Physiol 2007; 281: F26–F37.Google Scholar
53Pathak, S, Lees, C. Ultrasound structural fetal anomaly screening: an update. Arch Dis Child Fetal Neonatal Ed 2009; 94: F384–F390.CrossRefGoogle ScholarPubMed
54Sebire, NJ, Von Kaisenberg, C, Rubio, C, Snijders, RJ, Nicolaides, KH. Fetal megacystis at 10–14 weeks of gestation. Ultrasound Obstet Gynecol 1996; 8: 387–90.CrossRefGoogle ScholarPubMed
55Matsui, F, Shimada, K, Matsumoto, F, Obara, T. Prenatal resolution of megacystis possibly caused by spontaneous rupture of posterior urethral valves. J Pediatr Surg 2008; 43: 2285–287.CrossRefGoogle ScholarPubMed
56Robyr, R, Benachi, A, Daikha-Dahmane, F, Martinovich, J, Dumez, Y, Ville, Y. Correlation between ultrasound and anatomical findings in fetuses with lower urinary tract obstruction in the first half of pregnancy. Ultrasound Obstet Gynecol 2005; 25: 478–82.CrossRefGoogle ScholarPubMed
57Montemarano, H, Bulas, DI, Rushton, HG, Selby, D. Bladder distention and pyelectasis in the male fetus: causes, comparisons, and contrasts. J Ultrasound Med 1998; 17: 743–49.CrossRefGoogle ScholarPubMed
58Kaefer, M, Barnewolt, C, Retik, AB, Peters, CA. The sonographic diagnosis of infravesical obstruction in children: evaluation of bladder wall thickness indexed to bladder filling. J Urol 1997; 157: 989–91.CrossRefGoogle ScholarPubMed
59Abbott, JF, Levine, D, Wapner, R. Posterior urethral valves: inaccuracy of prenatal diagnosis. Fetal Diagn Ther 1998; 13:179–83.CrossRefGoogle ScholarPubMed
60Ismaili, K, Hall, M, Piepsz, A, Wissing, KM, Collier, F, Schulman, C et al. Primary vesicoureteral reflux detected in neonates with a history of fetal renal pelvis dilatation: a prospective clinical and imaging study. J Pediatr 2006; 148: 222–27.CrossRefGoogle ScholarPubMed
61Ek, S, Lidefeldt, KJ, Varricio, L. Fetal hydronephrosis; prevalence, natural history and postnatal consequences in an unselected population. Acta Obstet Gynecol Scand 2007; 86: 1463–466.CrossRefGoogle Scholar
62Paduano, L, Giglio, L, Bembi, B, Peratoner, L, D'Ottavio, G, Benussi, G. Clinical outcome of fetal uropathy. I. Predictive value of prenatal echography positive for obstructive uropathy. J Urol 1991; 146: 1094–1096.CrossRefGoogle ScholarPubMed
63Kaefer, M, Peters, CA, Retik, AB, Benacerraf, BB. Increased renal echogenicity: a sonographic sign for differentiating between obstructive and nonobstructive etiologies of in utero bladder distension. J Urol 1997; 158: 1026–1029.CrossRefGoogle ScholarPubMed
64de Jong, TP, Radmayr, C, Dik, P, Chrzan, R, Klijn, AJ, de Kort, L. Posterior urethral valves: search for a diagnostic reference standard. Urology 2008; 72: 1022–1025.CrossRefGoogle ScholarPubMed
65Heikkilä, J, Taskinen, S, Rintala, R. Urinomas associated with posterior urethral valves. J Urol 2008; 180: 1476–478.CrossRefGoogle ScholarPubMed
66Kihara, T, Nakai, H, Mori, K, Sato, R, Kitahara, S, Yasuda, K. Variety of congenital urethral lesions in boys with lower urinary tract symptoms and the results of endoscopic treatment. Int J Urol 2008; 15: 235–40.CrossRefGoogle ScholarPubMed
67Schober, JM, Dulabon, LM, Woodhouse, CR. Outcome of valve ablation in late-presenting posterior urethral valves. BJU Int 2004; 94: 616–19.CrossRefGoogle ScholarPubMed
68Ziylan, O, Oktar, T, Ander, H, Korgali, E, Rodoplu, H, Kocak, T. The impact of late presentation of posterior urethral valves on bladder and renal function. J Urol 2006; 175: 1894–897.CrossRefGoogle ScholarPubMed
69Köksal, IT, Usta, M, Erdoğru, T, Ateş, M, Kukul, E, Baykara, M. Incidental adult posterior urethral valve without clinical features. Int Urol Nephrol 2003; 35: 227–29.CrossRefGoogle ScholarPubMed
70Maranya, GA. Posterior urethral valves in the adult: report of two cases. East Afr Med J 2004; 81: 430–32.CrossRefGoogle ScholarPubMed
71Parkhouse, HF, Barratt, TM, Dillon, MJ, Duffy, PG, Fay, J, Ransley, PG et al. Long-term outcome of boys with posterior urethral valves. Br J Urol 1988 62: 59–62.CrossRefGoogle ScholarPubMed
72Ghanem, MA, Wolffenbuttel, KP, De Vylder, A, Nijman, RJ. Long-term bladder dysfunction and renal function in boys with posterior urethral valves based on urodynamic findings. J Urol 2004; 171: 2409–412.CrossRefGoogle ScholarPubMed
73De Gennaro, M, Capitanucci, ML, Mosiello, G, Caione, P, Silveri, M. The changing urodynamic pattern from infancy to adolescence in boys with posterior urethral valves. BJU Int 2000; 85: 1104–108.CrossRefGoogle ScholarPubMed
74Holmdahl, G, Sillén, U, Hanson, E, Hermansson, G, Hjälmås, K. Bladder dysfunction in boys with posterior urethral valves before and after puberty. J Urol 1996; 155: 694–98.CrossRefGoogle ScholarPubMed
75Hale, JM, Wood, DN, Hoh, IM, Neild, GH, Bomanji, JB, Chu, A et al. Stabilization of renal deterioration caused by bladder volume dependent obstruction. J Urol 2009; 182 (4 Suppl): 1973–977.CrossRefGoogle ScholarPubMed
76Warren, J, Pike, JG, Leonard, MP. Posterior urethral valves in Eastern Ontario – a 30 year perspective. Can J Urol 2004; 11: 2210–215.Google ScholarPubMed
77González Celedón, C, Bitsori, M, Tullus, K. Progression of chronic renal failure in children with dysplastic kidneys. Pediatr Nephrol 2007; 22: 1014–1020.CrossRefGoogle ScholarPubMed
78Roth, KS, Carter, WH Jr, Chan, JC. Obstructive nephropathy in children: long-term progression after relief of posterior urethral valve. Pediatrics 2001; 107: 1004–1010.CrossRefGoogle ScholarPubMed
79Kousidis, G, Thomas, DF, Morgan, H, Haider, N, Subramaniam, R, Feather, S. The long-term outcome of prenatally detected posterior urethral valves: a 10 to 23-year follow-up study. BJU Int 2008; 102: 1020–1024.CrossRefGoogle Scholar
80Sanna-Cherchi, S, Ravani, P, Corbani, V, Parodi, S, Haupt, R, Piaggio, G et al. Renal outcome in patients with congenital anomalies of the kidney and urinary tract. Kidney Int 2009; 76: 528–33.CrossRefGoogle ScholarPubMed
81Ylinen, E, Ala-Houhala, M, Wikström, S. Prognostic factors of posterior urethral valves and the role of antenatal detection. Pediatr Nephrol 2004; 19: 874–79.CrossRefGoogle ScholarPubMed
82DeFoor, W, Clark, C, Jackson, E, Reddy, P, Minevich, E, Sheldon, C. Risk factors for end stage renal disease in children with posterior urethral valves. J Urol 2008; 180: 1705–708.CrossRefGoogle ScholarPubMed
83Holmdahl, G, Sillén, U. Boys with posterior urethral valves: outcome concerning renal function, bladder function and paternity at ages 31 to 44 years. J Urol 2005; 174:1031–1034.CrossRefGoogle ScholarPubMed
84Neild, GH. What do we know about chronic renal failure in young adults? II. Adult outcome of pediatric renal disease. Pediatr Nephrol 2009; 24: 1921–928.CrossRefGoogle ScholarPubMed
85Hutton, KA, Thomas, DF, Arthur, RJ, Irving, HC, Smith, SE. Prenatally detected posterior urethral valves: is gestational age at detection a predictor of outcome? J Urol 1994; 152: 698–701.CrossRefGoogle ScholarPubMed
86Sarhan, O, Zaccaria, I, Macher, MA, Muller, F, Vuillard, E, Delezoide, AL et al. Long-term outcome of prenatally detected posterior urethral valves: single center study of 65 cases managed by primary valve ablation. J Urol 2008; 179: 307–12.CrossRefGoogle ScholarPubMed
87Morris, RK, Malin, GL, Khan, KS, Kilby, MD. Antenatal ultrasound to predict postnatal renal function in congenital lower urinary tract obstruction: systematic review of test accuracy. BJOG 2009; 116: 1290–299.CrossRefGoogle ScholarPubMed
88Desai, D, Godley, M, Ransley, P, Nicolaides, K, Chitty, L, Dhillon, H. Posterior urethral valves (PUV): prenatal ultrasound findings and their correlation with glomerular filtration rate (GFR) at 1 year of age. J Pediatr Urol 2008; 4: S68.CrossRefGoogle Scholar
89Johnson, MP, Bukowski, TP, Reitleman, C, Isada, NB, Pryde, PG, Evans, MI. In utero surgical treatment of fetal obstructive uropathy: a new comprehensive approach to identify appropriate candidates for vesicoamniotic shunt therapy. Am J Obstet Gynecol 1994; 170: 1770–776.CrossRefGoogle ScholarPubMed
90Favre, R, Kohler, M, Gasser, B, Muller, F, Nisand, I. Early fetal megacystis between 11 and 15 weeks of gestation. Ultrasound Obstet Gynecol 1999; 14: 402–406.CrossRefGoogle ScholarPubMed
91Jouannic, JM, Hyett, JA, Pandya, PP, Gulbis, B, Rodeck, CH, Jauniaux, E. Perinatal outcome in fetuses with megacystis in the first half of pregnancy. Prenat Diagn 2003; 23: 340–44.CrossRefGoogle ScholarPubMed
92Rees, L. Management of the infant with end-stage renal failure. Nephrol Dial Transplant 2002; 17: 1564–567.CrossRefGoogle ScholarPubMed
93Klaassen, I, Neuhaus, TJ, Mueller-Wiefel, DE, Kemper, MJ. Antenatal oligohydramnios of renal origin: long-term outcome. Nephrol Dial Transplant 2007; 22: 432–39.CrossRefGoogle ScholarPubMed
94McMann, LP, Kirsch, AJ, Scherz, HC, Smith, EA, Jones, RA, Shehata, BM et al. Magnetic resonance urography in the evaluation of prenatally diagnosed hydronephrosis and renal dysgenesis. J Urol 2006; 176: 1786–792.CrossRefGoogle ScholarPubMed
95Craparo, FJ, Rustico, M, Tassis, B, Coviello, D, Nicolini, U. Fetal serum b2-microglobulin before and after bladder shunting: a 2-step approach to evaluate fetuses with lower urinary tract obstruction. J Urol 2007; 178: 2576–579.CrossRefGoogle Scholar
96Morris, RK, Quinlan-Jones, E, Kilby, MD, Khan, KS. Systematic review of accuracy of fetal urine analysis to predict poor postnatal renal function in cases of congenital urinary tract obstruction. Prenat Diagn 2007; 27: 900–11.CrossRefGoogle ScholarPubMed
97Quintero, RA, Johnson, MP, Romero, R, Smith, C, Arias, F, Guevara-Zuloaga, F, Cotton, DB, Evans, MI. In-utero percutaneous cystoscopy in the management of fetal lower obstructive uropathy. Lancet 1995; 346: 537–40.CrossRefGoogle ScholarPubMed
98Welsh, A, Agarwal, S, Kumar, S, Smith, RP, Fisk, NM. Fetal cystoscopy in the management of fetal obstructive uropathy: experience in a single European centre. Prenat Diagn 2003; 23: 1033–1041.CrossRefGoogle Scholar
99Holmes, N, Harrison, MR, Baskin, LS. Fetal surgery for posterior urethral valves: long-term postnatal outcomes. Pediatrics 2001; 108: E7.CrossRefGoogle ScholarPubMed
100Freedman, AL, Johnson, MP, Smith, CA, Gonzalez, R, Evans, MI. Long-term outcome in children after antenatal intervention for obstructive uropathies. Lancet 1999; 354: 374–77.CrossRefGoogle ScholarPubMed
101Clark, TJ, Martin, WL, Divakaran, TG, Whittle, MJ, Kilby, MD, Khan, KS. Prenatal bladder drainage in the management of fetal lower urinary tract obstruction: a systematic review and meta-analysis. Obstet Gynecol 2003; 102: 367–82.Google ScholarPubMed
102National Instiute for Health and Clinical Excellence. Fetal vesico-amniotic shunt for lower urinary tract outflow obstruction. December 2006 http://www.nice.org.uk/nicemedia/pdf/IPG202guidance.pdfGoogle Scholar
103PLUTO Trial website http://www.pluto.bham.ac.uk/Accessed 5 October 2009.Google Scholar
104Pluto Collaborative Study Group, Kilby, M, Khan, K, Morris, K, Daniels, J, Gray, R, Magill, L et al. PLUTO trial protocol: percutaneous shunting for lower urinary tract obstruction randomised controlled trial. BJOG 2007; 114: 904–905.Google ScholarPubMed
105Mukherjee, S, Joshi, A, Carroll, D, Chandran, H, Parashar, K, McCarthy, L. What is the effect of circumcision on risk of urinary tract infection in boys with posterior urethral valves? J Pediat Surg 2009; 44: 417–21.CrossRefGoogle ScholarPubMed
106Godbole, P, Wade, A, Mushtaq, I, Wilcox, DT. Vesicostomy vs primary ablation for posterior urethral valves: Always a difference in outcome? J Pediatr Urol 2007; 3: 273–75.CrossRefGoogle ScholarPubMed
107Kajbafzadeh, AM, Payabvash, S, Karimian, G. The effects of bladder neck incision on urodynamic abnormalities of children with posterior urethral valves. J Urol 2007; 178: 2142–217.CrossRefGoogle ScholarPubMed
108Wühl, E, Mehls, O, Schaefer, F; ESCAPE Trial Group. Antihypertensive and antiproteinuric efficacy of ramipril in children with chronic renal failure. Kidney Int 2004; 66: 768–76.CrossRefGoogle ScholarPubMed
109Ardissino, G, Viganò, S, Testa, S, Daccò, V, Paglialonga, F, Leoni, A et al. No clear evidence of ACEi efficacy on the progression of chronic kidney disease in children with hypodysplastic nephropathy–report from the ItalKid Project database. Nephrol Dial Transplant 2007; 22: 2525–530.CrossRefGoogle ScholarPubMed
110Kramer, A, Stel, VS, Tizard, J, Verrina, E, Rönnholm, K, Pálsson, R et al. Characteristics and survival of young adults who started renal replacement therapy during childhood. Nephrol Dial Transplant 2009; 24: 926–33.CrossRefGoogle ScholarPubMed
111Woodhouse, CR. The fate of the abnormal bladder in adolescence. J Urol 2001; 166: 2396–400.CrossRefGoogle ScholarPubMed
112Hellström, AL, Berg, M, Sölsnes, E, Holmdahl, G, Sillén, U. Feeling good in daily life: from the point of view of boys with posterior urethral valves. J Urol 2006; 176: 1742–746.CrossRefGoogle ScholarPubMed
113Abraham, MK, Nasir, AR, Sudarsanan, B, Puzhankara, R, Kedari, PM, Unnithan, GR et al. Role of alpha adrenergic blocker in the management of posterior urethral valves. Pediatr Surg Int 2009 [Epub ahead of print] PMID: 19727771.CrossRefGoogle Scholar
114Johal, NS, Hamid, R, Aslam, Z, Carr, B, Cuckow, PM, Duffy, PG. Ureterocystoplasty: long-term functional results. J Urol 2008; 179: 2373–375.CrossRefGoogle ScholarPubMed
115Peters, CA, Bolkier, M, Bauer, SB, Hendren, WH, Colodny, AH, Mandell, J et al. The urodynamic consequences of posterior urethral valves. J Urol 1990; 144: 122–26.CrossRefGoogle ScholarPubMed
116Neild, GH, Dakmish, A, Wood, S, Nauth-Misir, R, Woodhouse, CR. Renal transplantation in adults with abnormal bladders. Transplantation 2004; 77: 1123–127.CrossRefGoogle ScholarPubMed
117Otukesh, H, Basiri, A, Simfroosh, N, Hoseini, R, Fereshtehnejad, SM, Chalian, M. Kidney transplantation in children with posterior urethral valves. Pediatr Transplant 2008; 12: 516–19.CrossRefGoogle ScholarPubMed
118Djakovic, N, Wagener, N, Adams, J, Gilfrich, C, Haferkamp, A, Pfitzenmaier, J et al. Intestinal reconstruction of the lower urinary tract as a prerequisite for renal transplantation. BJU Int 2009; 103: 1555–560.CrossRefGoogle ScholarPubMed