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SEPSIS IN PREGNANCY

Published online by Cambridge University Press:  19 December 2011

EILEEN SUNG ,
JULIE GEORGE  and
MICHELLE PORTER
EILEEN SUNG*
Affiliation:
Obstetric Physician, King Edward Memorial Hospital, Subiaco, Western Australia and Internal Medicine Physician, Sir Charles Gairdner Hospital, Nedlands, Western Australia
JULIE GEORGE
Affiliation:
Consultant, Department of Medicine, Tan Tock Seng Hospital, Singapore and Visiting Consultant, K. K Women's and Children's Hospital, Singapore
MICHELLE PORTER
Affiliation:
Microbiologist and Infectious Disease Physician, Microbiology Department, Pathwest Laboratories, Princess Margaret Hospital, SubiacoWestern Australia6008.
*
Eileen Sung, Obstetric Physician, King Edward Memorial Hospital, Subiaco, Western Australia. Email: eileen.sung@health.wa.gov.au
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Extract

Sepsis is associated with high morbidity and mortality worldwide. Although, it is not the major reason for intensive care unit admissions during pregnancy, several physiological changes that occur during pregnancy limit the ability of the pregnant woman to compensate for the derangements produced by severe sepsis, often resulting in severe organ dysfunction. Moreover, there are several disorders peculiar to the pregnant state, including preeclampsia, placental abruption, amniotic fluid embolism and postpartum haemorrhage, all of which can produce potentially life-threatening organ failure and may be present concurrently with sepsis contributing to maternal mortality. Evidence-based guidelines advocate assessment and monitoring aimed at early recognition and treatment of sepsis. Early goal-directed therapy, adequate blood glucose control, and corticosteroid replacement when indicated are improving outcomes in patients with severe sepsis, although most of these have not been validated in pregnancy.

Type
Review Article
Information
Fetal and Maternal Medicine Review , Volume 22 , Issue 4 , November 2011 , pp. 287 - 305
Copyright
Copyright © Cambridge University Press 2011

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