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Deletion analysis of male sterility effects of t–haplotypes in the mouse

Published online by Cambridge University Press:  14 April 2009

Dorothea Bennett  and
Karen Artzt
Dorothea Bennett*
Affiliation:
Department of Zoology, The University of Texas at Austin, Austin, Texas 78712-1064, USA
Karen Artzt
Affiliation:
Department of Zoology, The University of Texas at Austin, Austin, Texas 78712-1064, USA
*
* Corresponding author.

Summary

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We present data on the effects of three chromosome 17 deletions on transmission ratio distortion (TRD) and sterility of several t-haplotypes. All three deletions have similar effects on male TRD: that is, Tdel/tcomplete genotypes all transmit their t–haplotype in very high proportion. However, each deletion has different effects on sterility of heterozygous males, with Tor/t being fertile, Thp/t less fertile, and Torl/t still less fertile. These data suggest that wild-type genes on chromosomes homologous to f-haplotypes can be important regulators of both TRD and fertility in males, and that the wild-type genes concerned with TRD and fertility are at least to some extent different. The data also provide a rough map of the positions of these genes.

Type
Research Article
Information
Genetics Research , Volume 56 , Issue 2-3 , October 1990 , pp. 179 - 183
Copyright
Copyright © Cambridge University Press 1990

References

Bennett, D., Dunn, L. C., Spiegelman, M., Artzt, K., Cookingham, J. & Schermerhorn, E. (1975). Observations on a set of radiation-induced dominant T–like mutations in the mouse. Genetical Research 26, 95–108.CrossRefGoogle ScholarPubMed
Bennett, D., Alton, A. K. & Artzt, K. (1983). genetic analysis of transmission ratio distortion by t–haplotypes in the mouse. Genetical Research 41, 29–45.CrossRefGoogle ScholarPubMed
Dunn, L. C. & Bennett, D. (1969). Studies of effects of t–alleles in the house mouse on spermatozoa II. Quasi-sterility caused by different combinations of alleles, Journal of Reproduction and Fertility 20, 239–246.CrossRefGoogle ScholarPubMed
Fox, H. S., Martin, G. R., Lyon, M. F., Herrmann, B., Frischauf, A.-M., Lehrach, H. & Silver, L. M. (1985). Molecular probes define different regions of the mouse t–complex. Cell 40, 63–69.CrossRefGoogle ScholarPubMed
Gummere, G. R., McCormick, P. J. & Bennett, D. (1986). The influence of genetic background and the homologous chromosome 17 on t–haplotype transmission ratio distortion in mice. Genetics 114, 235–245.CrossRefGoogle ScholarPubMed
Hammerberg, C. (1981). The influence of T Orl upon male fertility in t–bearing mice. Genetical Research 37, 71–77.CrossRefGoogle ScholarPubMed
Johnson, D. R. (1974). Hairpin-tail: A case of postreductional gene action in the mouse egg? Genetics 76, 795–805.CrossRefGoogle ScholarPubMed
Lader, E., Ha, H.-S., Artzt, K. & Bennett, D. (1989). Tctex-1: A candidate gene family for a mouse t complex sterility locus. Cell 58, 969–979.CrossRefGoogle ScholarPubMed
Lyon, M. F., Herrmann, B. & Whitehill, K. (1989). Phenotypic effects of a presumed deletion of t–complex distorter-1 resembles the t–complex allele rather than wild-type. Genetical Research 53, 227.Google Scholar
Lyon, M. F. & Mason, I. (1977). Information on the nature of t–haplotypes from the interaction of mutant haplotypes in male fertility and segregation ratio. Genetical Research, 29, 255–266.CrossRefGoogle Scholar
Lyon, M. F. (1984). Transmission ratio distortion in mouse t–haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37, 621–628.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1986). Male sterility of the mouse t–complex is due to homozygosity of the distorter genes. Cell 44, 357–363.CrossRefGoogle ScholarPubMed
Moutier, R. (1973). Mouse News Letter 48, 38.Google Scholar
Sandier, L. & Golic, K. (1985). Segregation distortion in Drosphila. Trends in Genetics 1, 181–185.CrossRefGoogle Scholar