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Differences in or near the responder region of complete and partial mouse t-haplotypes

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon  and
Joanna Zenthon
Mary F. Lyon
Affiliation:
M.R.C. Radiobiology Unit, Chilton, Didcot, Oxon OX11 ORD, U.K.
Joanna Zenthon
Affiliation:
M.R.C. Radiobiology Unit, Chilton, Didcot, Oxon OX11 ORD, U.K.

Summary

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The transmission ratio distortion seen in males heterozygous for a mouse t-complex has been explained on the basis of trans-acting distorter genes, having a harmful effect on a responder gene. The t-complex form of the responder is relatively resistant to these harmful effects and hence is preferentially transmitted. Animals homozygous for the t-complex responder would be expected to show equal transmission of the two homologous chromosomes, but this is not always so. Studies described in this paper have shown differences among complete t's in their transmission when opposite a constant responder carrying partial t-haplotype. In addition, the proximal partial haplotypes th49 and tw18, both derived from tw5 but of different lengths, behave differently when opposite a responder. The three central partial haplotypes, tlowH, tlow2H and tlow3H, also differ, in that tlow3H shows lower transmission than tlowH or tloW2H when opposite either wild-type, or another responder, or distorter genes. These results can be explained either on the basis of differences in the responder region of various haplotypes, including the possibility of varying numbers of copies of the relevant sequences, or on the basis of differences in cis-acting (as opposed to trans-acting) distorter genes.

Type
Research Article
Information
Genetics Research , Volume 50 , Issue 1 , August 1987 , pp. 29 - 34
Copyright
Copyright © Cambridge University Press 1987

References

Artzt, K., Shin, H.-S. & Bennett, D. (1982). Gene mapping within the T/t complex of the mouse, II. Anomalous position of the H-2 complex in t haplotypes. Cell 28, 471–476.CrossRefGoogle Scholar
Fox, H. S., Martin, G. R., Lyon, M. F., Herrmann, B., Frischauf, A.-M., Lehrach, H. & Silver, L. M. (1985). Molecular probes define different regions of the mouse t-complex. Cell 40, 63–69.CrossRefGoogle ScholarPubMed
Hammerberg, C. (1982). The effects of the t-complex upon male reproduction are due to complex interactions between its several regions. Genetical Research 39, 219–226.CrossRefGoogle ScholarPubMed
Herrmann, B., Bućan, M., Mains, P., Frischauf, A.-M., Silver, L. M. & Lehrach, H. (1986). Genetic analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t haplotypes. Cell 44, 469–476.CrossRefGoogle Scholar
Lyon, M. F. (1984). Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37, 621–628.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1986). Male sterility of the mouse t-complex is due to homozygosity of the distorter genes. Cell 44, 357–363.CrossRefGoogle ScholarPubMed
Nižetić, D., Figueroa, F. & Klein, J. (1984). Evolutionary relationships between the t and H-2 haplotypes in the house mouse. Immunogenetics 19, 311–320.CrossRefGoogle Scholar
Röhme, D., Fox, H., Herrmann, B., Frischauf, A.-M., Edstrom, J.-E., Mains, P., Silver, L. M. & Lehrach, H. (1984). Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes. Cell 36, 783–788.CrossRefGoogle Scholar
Sarvetnick, N., Fox, H. S., Mann, E., Mains, P. E., Elliott, R. W. & Silver, L. M. (1986). Non-homologous pairing in mice heterozygous for a t haplotype can produce recombinant chromosomes with duplications and deletions. Genetics 113, 723–734.CrossRefGoogle Scholar
Schimenti, J., Vold, L., Socolow, D. & Silver, L. M. (1987). An unstable family of large DNA elements in the center of the mouse t complex. Journal of Molecular Biology (in press).CrossRefGoogle Scholar
Shin, H. S., Flaherty, L., Artzt, K., Bennett, D. & Ravetch, J. (1983). Inversion in the H-2 complex t-haplotypes in mice. Nature 306, 380–383.CrossRefGoogle ScholarPubMed