Hostname: page-component-7bb8b95d7b-wpx69 Total loading time: 0 Render date: 2024-09-15T06:21:00.578Z Has data issue: false hasContentIssue false
  • English
  • Français

Genetic analysis of the tw73 haplotype of the mouse using deletion mutations: evidence for a parasitic lethal mutation

Published online by Cambridge University Press:  14 April 2009

Bruce Babiarz ,
G. John Garrisi  and
Dorothea Bennett
Bruce Babiarz
Affiliation:
Sloan-Kettering Institute for Cancer Research, New York, N. Y. 10021
G. John Garrisi
Affiliation:
Sloan-Kettering Institute for Cancer Research, New York, N. Y. 10021
Dorothea Bennett
Affiliation:
Sloan-Kettering Institute for Cancer Research, New York, N. Y. 10021

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Matings between mice bearing the dominant deletion Thp and mice segregating for the tw73 haplotype failed to produce the expected viable tailless (Thp/tw73) progeny. Histological analysis of litters from Thp / + × + /tw73 matings revealed an abnormal class of embryos which failed to implant normally between days 6·5 and 7·5 of gestation, and were indistinguishable from tw73/tw73 homozygotes. Thp homozygotes displayed a different lethal phenotype, failing to successfully make the transition from morula to blastocyst at day 3·5. These studies indicate that the mutation responsible for the tw73 implantation defect maps within the Thp deletion. Since tw73 is viable with another deletion, Torl, the tw73 defect must occur in the region of non-overlap between Thp and TOrl. The possibility that the tw73-associated implantation defect is a parasitic lethal mutation (p), mapping to the proximal part of the tw73 chromosome, is discussed.

Type
Research Article
Information
Genetics Research , Volume 39 , Issue 2 , April 1982 , pp. 111 - 120
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Alton, A. K., Silver, L. M., Artzt, K. & Bennett, D. (1980). Genetic relationship of trans interacting factors at the T/t complex: a molecular analysis. Nature 228, 368–370.CrossRefGoogle Scholar
Bennett, D. (1975). The T-locus of the mouse. Cell 6, 441–454.CrossRefGoogle Scholar
Bennett, D. (1980). The T-complex in the mouse: an assessment after 50 years of study. The Harvey Lectures, Series 74.Google ScholarPubMed
Chesley, P. (1935). Development of the short-tailed mutant in the house mouse. Journal of Experimental Zoology 70, 429–459.CrossRefGoogle Scholar
Dobrovolskaia-Zavadskaia, N. (1927). Sur la mortification spontanée de la queue chez la souris nouveau-née et sur l'existence d'un caractère (facteur) héréditaire ‘non viable’. Compte Rendu des Séances de la Société de Biologie, Paris 97, 114–116.Google Scholar
Dunn, L. C. & Bennett, D. (1968). A new case of transmission ratio distortion in the house mouse. Proceedings of the National Academy of Sciences U.S.A. 61, 570–573.CrossRefGoogle ScholarPubMed
Dunn, L. C. & Bennett, D. (1971). Further studies of a mutation (Low) which distorts transmission ratios in the house mouse. Genetics 67, 543–558.CrossRefGoogle ScholarPubMed
Erickson, R. P., Lewis, S. E. & Slusser, K. S. (1978). Deletion mapping of the t–complex of chromosome 17 of the mouse. Nature 274, 163–164.CrossRefGoogle ScholarPubMed
Hammerberg, C. (1981). The influence of T orl upon male fertility in t–bearing mice. Genetical Research 37, 71–77.CrossRefGoogle ScholarPubMed
Hammerberg, C. & Klein, J. (1975). Linkage disequilibrium between H-2 and t-complex in chromosome 17 of the mouse. Nature 258, 296–299.CrossRefGoogle Scholar
Johnson, D. R. (1974). Hairpin tail: a case of post-reductional gene action in the mouse egg? Genetics 76, 795–805.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Meredith, R. (1964). Investigations of the nature of t–alleles in the mouse. I. Genetic analysis of series of mutants derived from a lethal allele. Heredity 19, 301–312.CrossRefGoogle ScholarPubMed
Moutier, R. (1973 a). Personal communication. In Mouse News Letter 48, 38.Google Scholar
Moutier, R. (1973 b). Personal communication. In Mouse News Letter 49, 42.Google Scholar
Silver, L. M. (1981). A structural gene (Tcp-1) within the mouse t complex is separable from effects on tail length and lethality but may be associated with effects on spermatogenesis. Genetical Research (in the Press).CrossRefGoogle Scholar
Silver, L. M., Artzt, K. & Bennett, T. (1979). A major testicular cell protein specified by a mouse T/t-complex gene. Cell 17, 275–284.CrossRefGoogle Scholar
Silver, L. M., White, M. & Artzt, K. (1980). Evidence for unequal crossing over within the mouse T/t complex. Proceedings of the National Academy of Sciences U.S.A. 77, 6077–6080.CrossRefGoogle ScholarPubMed
Sobotta, J. (1911). Die Entwicklung des Eies der Maus vom ersten Auftreten des Mesoderms an bis zur Ausbildung der Embryonenanlage und dem Auftreten der Allantois. Archiv für Mikroskopische Anatomie und Entivicklungsmechanik 78, 271–352.Google Scholar
Spiegelman, M., Artzt, K. & Bennett, D. (1976). Embryological study of a T/t locus mutation (t w73) affecting trophectoderm development. Journal of Embryology and Experimental Morphology 36, 373–381.Google Scholar