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Genetic analysis of transmission ratio distortion by t-haplotypes in the mouse

Published online by Cambridge University Press:  14 April 2009

Dorothea Bennett ,
Althea K. Alton  and
Karen Artzt
Dorothea Bennett
Affiliation:
Sloan-Kettering Institute for Cancer Research, New York, New York, USA
Althea K. Alton
Affiliation:
Sloan-Kettering Institute for Cancer Research, New York, New York, USA
Karen Artzt
Affiliation:
Sloan-Kettering Institute for Cancer Research, New York, New York, USA

Summary

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Lethal and semilethal t-haplotypes in the mouse are polymorphic in wild populations, where they are presumably maintained by transmission distortion from males, which transmit the aberrant chromosome to over 95% of progeny. We report here measurements of transmission ratio that show an unexpectedly strong effect of background genotype, specifically genes on the homologous chromosome, on the degree of transmission distortion of t-haplotypes. We also provide additional evidence that within t-haplotypes two separable elements co-operate to control transmission distortion, and that the system is thus closely analogous to segregation distortion in Drosophila, as has been previously proposed by Gluecksohn-Waelsch & Erickson (1970), Demin, Safronova & Lapkina (1978), and Styrna & Klein (1982).

Type
Research Article
Information
Genetics Research , Volume 41 , Issue 1 , February 1983 , pp. 29 - 45
Copyright
Copyright © Cambridge University Press 1983

References

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