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Nonprogressive sperm motility is characteristic of most complete t haplotypes in the mouse

Published online by Cambridge University Press:  14 April 2009

Patricia Olds-Clarke
Patricia Olds-Clarke
Affiliation:
Department of Anatomy, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A.

Summary

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Epididymal sperm from male mice carrying tw32 (t12 complementation group) exhibit a peculiar nonprogressive type of motility called ‘dancing’; sperm from congenie wild-type mice do not. To determine whether this effect was unique to tw32 or common to all t haplotypes, sperm from mice carrying other t haplotypes were examined. A male was considered to have nonprogressive sperm if more than 20% of the motile sperm had nonprogressive trajectories. The mean percentage of nonprogressive but motile sperm for 33 wild-type and Brachyury males of various genetic backgrounds was 4. All males carrying tw12 (tw1 complementation group), tw5 or tw73, and 56% of males carrying t0 or tLub1 had nonprogressive motile sperm. Five per cent of males carrying t chromatin or a deletion in the proximal (to the centromere) half of the t complex had nonprogressive motile sperm, but all males carrying t chromatin in the distal half of the t complex had nonprogressive motile sperm. These observations suggest that the factor or factors causing nonprogressive sperm motility may be common to all complete t haplotypes, and located in the distal region of the t complex.

Type
Research Article
Information
Genetics Research , Volume 42 , Issue 2 , October 1983 , pp. 151 - 157
Copyright
Copyright © Cambridge University Press 1983

References

REFERENCES

Babiarz, B., Garrisi, G. J. & Bennett, D. (1982). Genetic analysis of the t w73 haplotype of the mouse using deletion mutations: evidence for a parasitic lethal mutation. Genetical Research 39, 111–120.CrossRefGoogle ScholarPubMed
Bennett, D. (1975). The T-locus of the mouse. Cell 6, 441–454.CrossRefGoogle Scholar
Bennett, D., Dunn, L. C. & Artzt, K. (1976). Genetic change in mutations at the T/t-locus in the mouse. Genetics 83, 361–372.CrossRefGoogle Scholar
Erickson, R., Lewis, S. & Slusser, K. (1978). Deletion mapping of the t-complex of chromosome 17 of the mouse. Nature 274, 163–164.CrossRefGoogle ScholarPubMed
Guenet, J.-L., Condamine, H., Gaillard, J. & Jacob, F. (1980). t WPa−1, t wpa−2, t wpa−3. three new t-haplotypes in the mouse. Genetical Research 36, 211–217.CrossRefGoogle ScholarPubMed
Klein, J., Gotze, D., Nadeau, J. & Wakeland, E. (1981). Population immunogenetics of murine H-2 and t systems. Symposia of the Zoological Society of London no. 47, pp. 439–453.Google Scholar
Lyon, M. F. (1981). The t-complex and the genetical control of development. Symposia of the Zoological Society of London, no. 47, 455–477.Google Scholar
Ojakian, G. & Katz, D. F. (1973). A simple technique for the measurement of swimming speed of Chlamydomonas. Experimental Cell Research 81, 487–491.CrossRefGoogle ScholarPubMed
Olds-clarke, P. (1983). The nonprogressive motility of sperm populations from mice with a t w32 haplotype. Journal of Andrology 4, 136–143.CrossRefGoogle ScholarPubMed
Olds-clarke, P. & Carey, J. E. (1978). Rate of egg penetration in vitro accelerated by T/t locus in the mouse. Journal of Experimental Zoology 206, 323–332.CrossRefGoogle Scholar
Olds-clarke, P. & McCabe, S. (1982). Genetic background affects expression of t-haplotype in mouse sperm. Genetical Research 40, 249–254.CrossRefGoogle ScholarPubMed
Sherman, M. I. & Wudl, L. R. (1977). T-complex mutations and their effects. In Concepts in Mammalian Embryogenesis (ed. Sherman, M. I.), pp. 136–234. Cambridge, Mass: MIT Press.Google Scholar
Shur, B. D. (1981). Galactosyltransferase activities on mouse sperm bearing multiple t lethal and t Viable haplotypes of the T/t complex. Genetical Research 38, 225–236.CrossRefGoogle ScholarPubMed
Silver, L. (1981 a). Genetic organization of the mouse t complex. Cell 27, 239–240.CrossRefGoogle ScholarPubMed
Silver, L. (1981 b). A structural gene (Tcp-1) within the mouse t complex is separable from effects on tail length and lethality but may be associated with effects on spermatogenesis. Genetical Research 38, 115–123.CrossRefGoogle Scholar
Silver, L., Lukralle, D. & Garrels, J. (1983). T or1 is a novel, variant form of mouse chromosome 17 with a deletion in a partial t haplotype. Nature 301, 422–424.CrossRefGoogle Scholar
Styrna, J. & Klein, J. (1981). Evidence for two regions in the mouse t complex controlling transmission ratios. Genetical Research 38, 315–325.CrossRefGoogle Scholar
Tessler, S., Carey, J. E. & Olds-Clarke, P. (1981). Mouse sperm motility affected by factors in the T/t complex. Journal of Experimental Zoology 217, 277–285.CrossRefGoogle ScholarPubMed
Tessler, S. & Olds-Clarke, P. (1981). Male genotype influences sperm transport in female mice. Biology of Reproduction 24, 806–813.CrossRefGoogle ScholarPubMed
Yanagimachi, R. (1981). Mechanisms of fertilization in mammals. In Fertilization and Embryonic Development in vitro (ed. Mastroianni, L. and Biggers, J. D.), pp. 82–182. New York: Plenum.Google Scholar